Overview
- Editors:
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Margaret A. Shupnik
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Division of Endocrinology, Department of Internal Medicine, University of Virginia Health Sciences Center, Charlottesville, USA
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Table of contents (19 chapters)
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Growth, Development, and Metabolism
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- Michael J. Quon, Simeon I. Taylor
Pages 17-38
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- Andrew P. Bradford, Arthur Gutierrez-Hartmann
Pages 39-65
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- Bryan R. Haugen, David F. Gordon, William M. Wood
Pages 67-86
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- Uma R. Chandran, Donald B. DeFranco
Pages 87-97
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- Jung-Hsin Hsu, Gregory A. Brent
Pages 119-133
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- Ronald N. Cohen, Fredric E. Wondisford
Pages 135-151
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- Mark W. Nachtigal, Debra Enyeart-VanHouten, Holly A. Ingraham
Pages 153-166
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Reproductive System
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- T. Rajendra Kumar, Martin M. Matzuk
Pages 167-216
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- Kathryn E. Graham, Malcolm J. Low
Pages 217-237
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- Abir Mukherjee, Kelly E. Mayo
Pages 277-306
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- Veronica Soloveva, Jiandie Lin, Grace T. Ma, Daniel I. H. Linzer
Pages 307-322
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- Philip B. Daniel, Joel F. Habener
Pages 323-337
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About this book
During the past five to ten years, a variety of tools has been developed in the disciplines of both gene engineering, and molecular and structural biology. Some of these advances have permitted scientists not only to identify and characterize genes, but also to target these genes by disruption, thus eliminating their function in living animals, and to det- mine the biological responses to altered gene products. This has particular significance in endocrine systems, in which feedback mechanisms between the hypothalamus, pi- itary, and end organs are critical in normal physiology. Interpretation of the physiological significance, or the site of action of specific molecules in this context, has been difficult prior to transgenic technology. Major advances have occurred specifically in the areas of growth and development, and of reproduction. Coupled with analysis of naturally occurring mutations in humans, the use of transgenic animals and in vitro systems has recently allowed endocrinologists to understand the importance of specific thyroid hormone receptor isoforms in vivo, the molecular basis for generalized resistance to thyroid hormones via mutations in the nuclear receptor, and mechanisms for suppressing gene transcription. Previously designated “orphan rec- tors,” such as steroidogenic factor-1, were demonstrated to have critical roles in dev- opment and reproduction. Other nuclear receptors—including those for thyroid hormone, estrogens, androgens, and progesterone—were shown to bind to coactivator and co- pressor proteins that modified their transcriptional activity, and contributed to the ce- specific effects of the hormones.
Reviews
"The editor should be congratulated on bringing together some of the most respected researchers in this area to write state-of-the-art papers in the area of molecular endocrinology. . . Graduate students and fellows interested in basic endocrinology would find this book a worthwhile investment with good diagrams and well-written summaries of some of the more confusing areas of this field. . .I love the book and will keep it handy when I sit down and decipher the new papers in molecular biology."-Doody's Health Science Book Review Journal
Editors and Affiliations
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Division of Endocrinology, Department of Internal Medicine, University of Virginia Health Sciences Center, Charlottesville, USA
Margaret A. Shupnik
