Overview
- Editors:
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Thomas J. Evans
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Imperial College School of Medicine, London, UK
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Table of contents (18 protocols)
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Endotoxin
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- Paul A. Ketchum, Thomas J. Novitsky
Pages 3-12
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- Alexander Shnyra, Michael Luchi, David C. Morrison
Pages 13-25
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Other Bacterial Products
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- Manuela Roggiani, Patrick M. Schlievert
Pages 59-66
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Cytokines
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- Maarten G. Bouma, Wim A. Buurman
Pages 91-100
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- Daniel G. Remick, David E. Newcomb, Jon S. Friedland
Pages 101-112
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Nitric Oxide and Other Reactive Nitrogen Intermediates
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Front Matter
Pages 113-113
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- Dilani K. Siriwardena, Hajime Tagori, Christoph Thiemermann
Pages 115-131
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- Lee D. K. Buttery, Julia M. Polak
Pages 145-157
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- Liliana Viera, Yao Zu Ye, Joseph S. Beckman
Pages 159-169
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- Stuart Malcolm, Raymond Foust III, Caryn Hertkorn, Harry Ischiropoulos
Pages 171-177
About this book
Septic shock remains a serious medical condition with high mortality. Despite many advances in intensive care medicine and antibiotic devel- ment, this has not changed appreciably in the last 20 years. Frustratingly, over the same period of time, enormous advances have been made in understa- ing the underlying pathogenic mechanisms of this condition. This has resulted in the development of several novel therapies for septic shock, which, despite excellent theoretical grounds for their efficacy, have failed in altering mort- ity attributable to sepsis. The reasons for these failures are multiple, but it is clear that further research is required aimed at increasing our understanding of the basic pat- physiological processes that occur following infection. Research into septic shock draws upon a number of different disciplines, ranging from molecular and cellular biology to physiological measurements on whole animals. Septic Shock Methods and Protocols is an attempt to draw together into one volume a number of protocols that are of use in the investigation of the mechanisms of septic shock. I have divided the book into five sections. The first deals with endotoxin, the lipopolysaccharide component of the Gram-negative cell m- brane that can mimic many of the features of septic shock. Gram-positive organisms are found increasingly as causes of septic shock, and several - pects of toxins produced from these bacteria are considered in the second s- tion.
Reviews
"this text is a fine laboratory reference. . . the editor has done an excellent job in the organization of the text and has selected well-qualified investigators who have made a commendable contribution to the various sections of the book. This text is appropriate for a broad-range of interdisciplinary investigators and students engaged in septic shock/infection studies. "-Doody's Health Sciences Book Review Journal
Editors and Affiliations
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Imperial College School of Medicine, London, UK
Thomas J. Evans
