Overview
- Editors:
-
-
Timothy S. Gaginella
-
School of Pharmacy, University of Wisconsin, Madison, USA
-
Antonio Guglietta
-
Parke-Davis Pharmaceutical Research Division, Ann Arbor, USA
Access this book
Other ways to access
Table of contents (9 chapters)
-
-
-
- B. L. Tepperman, B. J. R. Whittle
Pages 21-60
-
- Alan D. Levine, Claudio Fiocchi
Pages 61-87
-
- Antonio Guglietta, Marija Veljača
Pages 89-112
-
-
- Massimo D’Amato, Francesco Makovec, Lucio C. Rovati
Pages 147-176
-
- Sushil K. Sarna, Michel R. Briefer, Jan A. J. Schuurkes
Pages 177-202
-
- Pierre J. M. Rivière, Jean-Louis Junien
Pages 203-238
-
- Gabriella Coruzzi, Enzo Poli, Giuseppina Morini, Giulio Bertaccini
Pages 239-267
-
Back Matter
Pages 269-278
About this book
The application of molecular techniques to gastroenterology continues to yield important advances in the development of drugs to treat gastrointestinal disorders. Important new drugs have emerged through the collaborative and complementary efforts of basic scientists, clinicians, and clinical researchers in academia and the pharmaceutical industry. The challenge has been exciting, with a few surprises along the way. Consider peptic ulcer disease as an example. The discovery of H receptors and the availability of potent and 2 selective H-receptor antagonists signaled the beginning of a new era 2 in the treatment of gastric hypersecretory states and peptic ulcers. Introduction of proton pump inhibitors offered another therapeutic option. Though H-receptor antagonists and proton pump inhibitors 2 are important and useful drugs, the discovery of the link between H. pylori infection and peptic ulcer disease has led to even more effective pharmacotherapeutic regimens. Our intent in Drug Development: Molecular Targets for GI Diseases is to bring together hands-on experts to review promising areas of gastrointestinal pharmacology. The contemporary topics covered, from a mechanistic viewpoint, are relevant to gastrointestinal inflammation and motility disorders. Authoritative opinions are offered on both future research directions and potential applications for new therapies.
Reviews
"The book focuses on specific molecules and the drugs that act on them, their receptors, metabolism or synthesis. . . a useful text for investigators of GI function and for pharmacologists interested in therapeutic compounds, their actions and targets."-Trends in Pharmaceutical Sciences
Editors and Affiliations
-
School of Pharmacy, University of Wisconsin, Madison, USA
Timothy S. Gaginella
-
Parke-Davis Pharmaceutical Research Division, Ann Arbor, USA
Antonio Guglietta
