Overview
- Editors:
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John A. Double
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Cancer Research Unit, University of Bradford Bradford, West Yorkshire, UK
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Michael J. Thompson
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Cancer Research Unit, University of Bradford Bradford, West Yorkshire, UK
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Table of contents (15 protocols)
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- Jean-Patrick Pommier, Laure Sabatier
Pages 33-63
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- W. Nicol Keith, Joseph Sarvesvaran, Martin Downey
Pages 65-81
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- Dennis S. Salonga, Kathleen D. Danenberg, Jean Grem, Ji Min Park, Peter V. Danenberg
Pages 83-98
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- Thomas Emrich, Sheng-Yung Chang, Gerlinde Karl, Birgit Panzinger, Chris Santini
Pages 99-108
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- Jun-ichi Nakayama, Fuyuki Ishikawa
Pages 125-136
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- Wade K. Aldous, Amber J. Marean, Mary J. DeHart, Katherine H. Moore
Pages 137-146
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- Thomas Emrich, Gerlinde Karl
Pages 147-158
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- Kazuma Ohyashiki, Junko H. Ohyashiki
Pages 159-164
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- Henriette Gourdeau, Marsha D. Speevak, Lucie Jetté, Mario Chevrette
Pages 173-195
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- Imad Naasani, Takao Yamori, Takashi Tsuruo
Pages 197-207
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Back Matter
Pages 217-221
About this book
The fundamental problem that dividing cells have to ov- come is that of end-replication. Chromosomes shorten by many bases during DNA replication and so this presents a major hurdle that a cell has to overcome both to enable it to proliferate and for the larger organism to survive and reproduce. The enzyme telomerase provides a mechanism to ensure chromosome stability in both normal and neoplastic cells. The demonstration of telomerase expression in a majority of tumors and the realization of the potential role of telomerase in aging has opened up the potential for telomerase to be used as a target for therapeutic intervention. There is therefore great interest in the expression and activity of telomerase in a wide range of biological disciplines. Telomeres and Telomerase: Methods and Protocols has been produced as a tool for the many researchers in different areas of cell biology who are interested in following research in the area of telomerase and telomere maintenance, either in the area of fundamental mec- nisms or perhaps in the area of more applied drug discovery work.
Reviews
"Among the many experimental protocols described in this book are methods for visualizing, manipulating, and assaying telomeres and telomerase activity. The protocols are written clearly and should serve as a useful laboratory resource for anyone wishing to learn how to study these entities. The book has a utilitarian look and feel, and while illustrations are not a major feature of the book, the ones that are included are of adequate quality. This book is intended and written as a laboratory guide manual. It would be quite useful for anyone doing bench research on telomeres and telomerase."-Doody's Health Sciences Book Review Journal
