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Quantitative Trait Loci

Methods and Protocols

  • Book
  • © 2002

Overview

Editors:
  1. Nicola J. Camp

    1. Genetic Epidemiology, Department of Medical Informatics, University of Utah School of Medicine, Salt Lake City

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    You can also search for this editor in PubMed   Google Scholar

  2. Angela Cox

    1. Institute for Cancer Studies, University of Sheffield Medical School, Sheffield, UK

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    You can also search for this editor in PubMed   Google Scholar

Part of the book series: Methods in Molecular Biology (MIMB, volume 195)

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Table of contents (12 protocols)

  1. Front Matter

    Pages i-xii
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  2. Mapping Quantitative Trait Loci in Humans

    1. Front Matter

      Pages 1-1
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    2. Association Studies

      • Jennifer H. Barrett
      Pages 3-12

    3. Parametric Linkage Analysis

      • Lyle J. Palmer, Audrey H. Schnell, John S. Witte, Robert C. Elston
      Pages 13-35

    4. Nonparametric Linkage Analysis

      • Chad P. Garner
      Pages 37-60

    5. Nonparametric Linkage Analysis

      • Angela J. Marlow
      Pages 61-100

    6. Linkage and Association

      • Mark M. Iles
      Pages 101-138

    7. Joint Linkage and Segregation Analysis Using Markov Chain Monte Carlo Methods

      • Ellen M. Wijsman
      Pages 139-161

  3. Mapping Quantitative Trait Loci in Rodents

    1. Front Matter

      Pages 163-163
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    2. Approaches to the Analysis of QTL Data in Mice, Using the Nonobese Diabetic Mouse as an Example

      • Heather J. Cordell
      Pages 165-198

    3. Experimental Designs for QTL Fine Mapping in Rodents

      • Anne Shalom, Ariel Darvasi
      Pages 199-223

    4. Approaches to the Analysis of Complex Quantitative Phenotypes and Marker Map Construction Based on the Analysis of Rat Models of Hypertension

      • Dominique Gauguier, Nilesh Samani
      Pages 225-251

    5. Case Study of QTL Analysis in a Mouse Model of Asthma

      • Youming Zhang, William Cookson
      Pages 253-279

  4. Mapping Quantitative Trait Loci in Agricultural Settings

    1. Front Matter

      Pages 281-281
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    2. QTL Analysis in Plants

      • Shizhong Xu
      Pages 283-310

    3. QTL Analysis in Livestock

      • Joao L. Rocha, Daniel Pomp, L. Dale Van Vleck
      Pages 311-346

  5. Back Matter

    Pages 347-359
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About this book

In Quantitative Trait Loci: Methods and Protocols, a panel of highly experienced statistical geneticists demonstrate in a step-by-step fashion how to successfully analyze quantitative trait data using a variety of methods and software for the detection and fine mapping of quantitative trait loci (QTL). Writing for the nonmathematician, these experts guide the investigator from the design stage of a project onwards, providing detailed explanations of how best to proceed with each specific analysis, to find and use appropriate software, and to interpret results. Worked examples, citations to key papers, and variations in method ease the way to understanding and successful studies. Among the cutting-edge techniques presented are QTDT methods, variance components methods, and the Markov Chain Monte Carlo method for joint linkage and segregation analysis.

Reviews

"...for nonstatistical students, this well-designed book provides 'detailed explanations of how best to proceed with each specific analysis, to find and use appropriate software, and to interpret results," as advertised on its back cover." - American Journal of Human Biology

Editors and Affiliations

  • Genetic Epidemiology, Department of Medical Informatics, University of Utah School of Medicine, Salt Lake City

    Nicola J. Camp

  • Institute for Cancer Studies, University of Sheffield Medical School, Sheffield, UK

    Angela Cox

Bibliographic Information

  • Book Title: Quantitative Trait Loci

  • Book Subtitle: Methods and Protocols

  • Editors: Nicola J. Camp, Angela Cox

  • Series Title: Methods in Molecular Biology

  • DOI: https://doi.org/10.1385/1592591760

  • Publisher: Humana Totowa, NJ

  • eBook Packages: Springer Protocols

  • Copyright Information: Humana Press 2002

  • Hardcover ISBN: 978-0-89603-927-8Published: 26 April 2002

  • Softcover ISBN: 978-1-61737-254-4Published: 10 November 2010

  • eBook ISBN: 978-1-59259-176-3Published: 03 February 2008

  • Series ISSN: 1064-3745

  • Series E-ISSN: 1940-6029

  • Edition Number: 1

  • Number of Pages: XII, 360

  • Topics: Human Genetics

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