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Tumor Targeting in Cancer Therapy

  • Book
  • © 2002

Overview

Editors:
  1. Michel Pagé

    1. Department of Medical Biology, Faculty of Medicine, Université Laval, Sainte-Foy, Canada

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Part of the book series: Cancer Drug Discovery and Development (CDD&D)

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Table of contents (24 chapters)

  1. Front Matter

    Pages i-x
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  2. A Review

    1. Front Matter

      Pages 1-1
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    2. The Current Status of Tumor Targeting

      • Tarunendu Ghose
      Pages 3-78

    3. Clinical Applications of Targeted Therapeutics

      • Tarunendu Ghose
      Pages 79-105

  3. Targeting Tumors with Drug Antibody Conjugates

    1. Front Matter

      Pages 107-107
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    2. Targeting the CD22 Receptor with RNA Damaging Agents

      • Huaitian Liu, Dianne L. Newton, Hans J. Hansen, Stanislaw M. Mikulski, David M. Goldenberg, Edward A. Sausville et al.
      Pages 109-118

    3. The Development of Liposomes for Enhanced Delivery of Chemotherapeutics to Tumors

      • Paul Tardi, Ludger Ickenstein, Marcel Bally, Lawrence Mayer
      Pages 119-135

    4. Overcoming Multiple Drug Resistance with Anti-Pgp Carrier

      • Brigitte PagĂ©, Michel PagĂ©
      Pages 137-149

    5. Targeting with Transferrin

      • Mandip Singh
      Pages 151-164

    6. Synthesis and Evaluation of Paclitaxel Immunoconjugate with Antitumor Activity In Vitro

      • Jairo Jaime Correa, Michel PagĂ©
      Pages 165-178

    7. The Use of Drug-Monoclonal Antibody Conjugates for the Treatment of Cancer

      • Geoffrey A. Pietersz, Ian F. C. McKenzie
      Pages 179-196

  4. Targeting Tumors with Antibodies

    1. Front Matter

      Pages 197-197
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    2. Targeting Vascular Endothelium with Antibodies

      • Przemek Twardowski, Kim Margolin
      Pages 199-210

    3. Targeting B-Cell Non-Hodgkin’s Lymphomas with Monoclonal Antibodies

      • Christian Buske, W. Hiddemann
      Pages 211-223

    4. From Bench to Bedside

      • Roland Newman
      Pages 225-237

    5. Mylotarg

      • Philip R. Hamann, Mark S. Berger
      Pages 239-254

  5. Targeting Tumors with Radioimmunoconjugates

    1. Front Matter

      Pages 255-255
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    2. 188Rhenium-Labeled Trisuccin-ΔCH2HuCC49 as a Radioimmunotherapy Model in Nude Mice

      • Ahmad Safavy, Donald J. Buchsbaum
      Pages 257-275

  6. Targeting Tumors with Immunotoxins

    1. Front Matter

      Pages 277-277
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    2. General Approach for Targeting Toxins

      • Manish Monga, Richard A. Messmann, Edward A. Sausville
      Pages 279-288
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Keywords

About this book

After many years of vigorous effort, the use of antibodies to target tumors has become highly successful both clinically and commercially. In Tumor Targeting in Cancer Therapy, Dr. Michel Pagé and a panel of authoritative experts from the drug industry, clinics, and academia introduce the principles and techniques of tumor targeting and critically survey their applications from laboratory to bedside. By concisely synthesizing the many technical details, the authors illuminate this innovative technique, ranging from the fundamentals of drug targeting and in vivo and in vitro experimentation, to such emerging therapeutic uses as radioimmunotherapy, radioimmunodetection, therapy with cytotoxic antibodies, immunotoxins, enzyme prodrug immunotherapy, and immunotherapeutics with fusion proteins. There are also reviews of targeting tumors with radioimmunoconjugates, photodynamic therapy, and magnetic drugs, as well as discussions of the internalization of antibodies, bioconjugation and biodistribution, the use of cytotoxic drugs, and the pros and cons of targeting by antibody or ligand.
Comprehensive and practical, Tumor Targeting in Cancer Therapy summarizes the essentials of tumor targeting as it is practiced today and provides all those engaged in experimental and clinical cancer research the critically established information needed to evaluate new technologies, investigate novel therapeutic agents, and apply them in relevant clinical practice.

Reviews

"This book stands out among many books with similar titles in that it deals with topics in a sequence that best describes the fundamentals and applications of drug targeting....Each chapter of the book was well balanced to have both basic and clinical aspects. This book is highly recommended for all graduate students, researchers, and clinicians who are involved in the antibody-based drug targeting." -- Pharmaceutical Research

"Tumor Targeting in Cancer Therapy represents an outstanding work, describing both experimental and clinical application of antibodies for targeting tumors." -Neoplasma

Editors and Affiliations

  • Department of Medical Biology, Faculty of Medicine, UniversitĂ© Laval, Sainte-Foy, Canada

    Michel Pagé

Bibliographic Information

  • Book Title: Tumor Targeting in Cancer Therapy

  • Editors: Michel PagĂ©

  • Series Title: Cancer Drug Discovery and Development

  • DOI: https://doi.org/10.1007/978-1-59259-167-1

  • Publisher: Humana Totowa, NJ

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer Science+Business Media New York 2002

  • Hardcover ISBN: 978-0-89603-919-3Published: 01 April 2002

  • Softcover ISBN: 978-1-61737-251-3Published: 19 November 2010

  • eBook ISBN: 978-1-59259-167-1Published: 01 April 2002

  • Series ISSN: 2196-9906

  • Series E-ISSN: 2196-9914

  • Edition Number: 1

  • Number of Pages: X, 463

  • Number of Illustrations: 39 b/w illustrations

  • Topics: Pharmacy

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