Tumor Targeting in Cancer Therapy

1. Front Matter

   Pages i-x

   PDF

2. A Review

   1. Front Matter

      Pages 1-1

      PDF

   2. The Current Status of Tumor Targeting

      • Tarunendu Ghose

      Pages 3-78

   3. Clinical Applications of Targeted Therapeutics

      • Tarunendu Ghose

      Pages 79-105

3. Targeting Tumors with Drug Antibody Conjugates

   1. Front Matter

      Pages 107-107

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   2. Targeting the CD22 Receptor with RNA Damaging Agents

      • Huaitian Liu, Dianne L. Newton, Hans J. Hansen, Stanislaw M. Mikulski, David M. Goldenberg, Edward A. Sausville et al.

      Pages 109-118

   3. The Development of Liposomes for Enhanced Delivery of Chemotherapeutics to Tumors

      • Paul Tardi, Ludger Ickenstein, Marcel Bally, Lawrence Mayer

      Pages 119-135

   4. Overcoming Multiple Drug Resistance with Anti-Pgp Carrier

      • Brigitte Pagé, Michel Pagé

      Pages 137-149

   5. Targeting with Transferrin

      • Mandip Singh

      Pages 151-164

   6. Synthesis and Evaluation of Paclitaxel Immunoconjugate with Antitumor Activity In Vitro

      • Jairo Jaime Correa, Michel Pagé

      Pages 165-178

   7. The Use of Drug-Monoclonal Antibody Conjugates for the Treatment of Cancer

      • Geoffrey A. Pietersz, Ian F. C. McKenzie

      Pages 179-196

4. Targeting Tumors with Antibodies

   1. Front Matter

      Pages 197-197

      PDF

   2. Targeting Vascular Endothelium with Antibodies

      • Przemek Twardowski, Kim Margolin

      Pages 199-210

   3. Targeting B-Cell Non-Hodgkin’s Lymphomas with Monoclonal Antibodies

      • Christian Buske, W. Hiddemann

      Pages 211-223

   4. From Bench to Bedside

      • Roland Newman

      Pages 225-237

   5. Mylotarg

      • Philip R. Hamann, Mark S. Berger

      Pages 239-254

5. Targeting Tumors with Radioimmunoconjugates

   1. Front Matter

      Pages 255-255

      PDF

   2. 188Rhenium-Labeled Trisuccin-ΔCH2HuCC49 as a Radioimmunotherapy Model in Nude Mice

      • Ahmad Safavy, Donald J. Buchsbaum

      Pages 257-275

6. Targeting Tumors with Immunotoxins

   1. Front Matter

      Pages 277-277

      PDF

   2. General Approach for Targeting Toxins

      • Manish Monga, Richard A. Messmann, Edward A. Sausville

      Pages 279-288

After many years of vigorous effort, the use of antibodies to target tumors has become highly successful both clinically and commercially. In Tumor Targeting in Cancer Therapy, Dr. Michel Pagé and a panel of authoritative experts from the drug industry, clinics, and academia introduce the principles and techniques of tumor targeting and critically survey their applications from laboratory to bedside. By concisely synthesizing the many technical details, the authors illuminate this innovative technique, ranging from the fundamentals of drug targeting and in vivo and in vitro experimentation, to such emerging therapeutic uses as radioimmunotherapy, radioimmunodetection, therapy with cytotoxic antibodies, immunotoxins, enzyme prodrug immunotherapy, and immunotherapeutics with fusion proteins. There are also reviews of targeting tumors with radioimmunoconjugates, photodynamic therapy, and magnetic drugs, as well as discussions of the internalization of antibodies, bioconjugation and biodistribution, the use of cytotoxic drugs, and the pros and cons of targeting by antibody or ligand.
Comprehensive and practical, Tumor Targeting in Cancer Therapy summarizes the essentials of tumor targeting as it is practiced today and provides all those engaged in experimental and clinical cancer research the critically established information needed to evaluate new technologies, investigate novel therapeutic agents, and apply them in relevant clinical practice.

• antibody-targeted chemotherapy
• cancer
• cancer therapy
• chemistry
• chemotherapy
• drug
• drug resistance
• immunotherapy
• lymphoma
• resistance
• tumor

"This book stands out among many books with similar titles in that it deals with topics in a sequence that best describes the fundamentals and applications of drug targeting....Each chapter of the book was well balanced to have both basic and clinical aspects. This book is highly recommended for all graduate students, researchers, and clinicians who are involved in the antibody-based drug targeting." -- Pharmaceutical Research

"Tumor Targeting in Cancer Therapy represents an outstanding work, describing both experimental and clinical application of antibodies for targeting tumors." -Neoplasma

• Department of Medical Biology, Faculty of Medicine, Université Laval, Sainte-Foy, Canada

  Michel Pagé

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