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Folate and Human Development

  • Book
  • © 2002

Overview

Editors:
  1. Edward J. Massaro

    1. The National Health and Environmental Effects Research Laboratory, Research Triangle Park, USA

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    You can also search for this editor in PubMed   Google Scholar

  2. John M. Rogers

    1. The National Health and Environmental Effects Research Laboratory, Research Triangle Park, USA

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    You can also search for this editor in PubMed   Google Scholar

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Table of contents (15 chapters)

  1. Front Matter

    Pages i-xii
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  2. Animal Models of Folate-Related Neural Tube Defects

    • Nicholas D. E. Greene, Andrew J. Copp
    Pages 1-26

  3. Genetic Variation in Folate Metabolism

    • Rima Rozen
    Pages 27-42

  4. Folate Deficiency and the Molecular Determinants of Chromosome Instability

    • S. Jill James, Charlotte A. Hobbs
    Pages 43-70

  5. Folic Acid, Vitamin B12, and Genomic Stability of Human Cells

    • Michael Fenech
    Pages 71-89

  6. Molecular Genetics of Folate Metabolism

    • Manuela Födinger, Sonja Skoupy, Gere Sunder-Plassmann
    Pages 91-115

  7. Folate Receptor-α

    • Barton A. Kamen
    Pages 117-135

  8. Folate, Homocysteine, and Neural Tube Defects

    • Tom K. A. B. Eskes
    Pages 137-163

  9. Folic Acid and Homocysteine as Risk Factors for Neural Tube Defects

    • Robert C. Barber, Janée van Waes, Edward J. Lammer, Gary M. Shaw, Thomas H. Rosenquist, Richard H. Finnell
    Pages 165-181

  10. Developmental Toxicants Potentially Acting via Folate Perturbation

    • Deborah K. Hansen
    Pages 183-203

  11. Brain Development and Choline, the Other Methyl Donor

    • Steven H. Zeisel
    Pages 205-218

  12. Nutrient Interactions Between Folate and Zinc or Copper

    • Tsunenobu Tamura
    Pages 219-240

  13. Regulation of Folate Metabolism by Iron

    • A. Katherine Herbig, Patrick J. Stover
    Pages 241-262

  14. A Differential Role for Folate in Developmental Disorders, Vascular Disease, and Other Clinical Conditions

    • Mark Lucock, Zoe Yates
    Pages 263-298

  15. Vascular Disease in Women

    • Tom K. A. B. Eskes
    Pages 299-328

  16. Folate, Homocysteine, and Cardiovascular Disease

    • Jayne V. Woodside, Ian S. Young
    Pages 329-344

  17. Back Matter

    Pages 345-359
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Keywords

About this book

Folic acid not only helps to prevent a variety of serious neural-tube birth defects-among them anencephaly and spina bifida-but is also an important factor in general human health. In Folate and Human Development, an authoritative panel of basic and clinical researchers critically reviews the latest findings on the role of folate in human development, health, and disease. Specific areas addressed include folate metabolism in zinc or copper deficiencies, choline and folate in development, animal models of folate-related birth defects, developmental toxicants potentially acting via folate perturbation, and folate's role in vascular disease in women. There are also cutting-edge discussions of genes and neural tube development, folate receptor polymorphism and the risk for neural defects, abnormal DNA synthesis and methylation with folate/methyl insufficiency, and folic acid and homocysteine as risk factors for neural-tube defects.
Comprehensive and up-to-date, Folate and Human Development critically evaluates our current understanding of the role of folates in human health and disease, offering biomedical and clinical researchers a deeper understanding of the folate and nutrient basis of neural-tube defects.

Reviews

"This multi-author volume reads like a research symposium. Each chapter, written by experts in their field, can be read independently without reference to the others. There is considerable repetition with several chapters providing, for example, overviews of folate metabolism. This book represents an invaluable resource for anyone embarking on research in the field of folic acid and birth defects." - Human Genetics

"Each chapter is very well referenced and up-to-date." -Journal of Paediatrics and Child Health

"This book represents an invaluable resource for anyone embarking on research in the field of folic acid and birth defects. This book old be a valuable reference source in any department of human genetics." -Human Genetics

Editors and Affiliations

  • The National Health and Environmental Effects Research Laboratory, Research Triangle Park, USA

    Edward J. Massaro, John M. Rogers

Bibliographic Information

  • Book Title: Folate and Human Development

  • Editors: Edward J. Massaro, John M. Rogers

  • DOI: https://doi.org/10.1007/978-1-59259-164-0

  • Publisher: Humana Totowa, NJ

  • eBook Packages: Springer Book Archive

  • Copyright Information: Humana Press 2002

  • Hardcover ISBN: 978-0-89603-936-0Published: 10 March 2002

  • Softcover ISBN: 978-1-61737-262-9Published: 05 November 2010

  • eBook ISBN: 978-1-59259-164-0Published: 10 March 2002

  • Edition Number: 1

  • Number of Pages: XII, 359

  • Topics: Public Health, Nutrition

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