Overview
- Editors:
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Maarten E. A. Reith
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Department of Biomedical and Therapeutic Sciences, University of Illinois College of Medicine, Peoria, USA
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Table of contents (13 chapters)
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- Nian-Hang Chen, Maarten E. A. Reith
Pages 53-109
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- Maureen K. Hahn, Randy D. Blakely
Pages 111-169
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- Raul R. Gainetdinov, Marc G. Caron
Pages 171-192
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- Scott L. Deken, Robert T. Fremeau Jr., Michael W. Quick
Pages 193-233
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- Yoshikatsu Kanai, Davide Trotti, Urs V. Berger, Matthias A. Hediger
Pages 255-311
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- Rodrigo Yelin, Shimon Schuldiner
Pages 313-354
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- Amrat P. Patel, Maarten E. A. Reith
Pages 355-380
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- F. Ivy Carroll, Anita H. Lewin, S. Wayne Mascarella
Pages 381-432
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- S. John Gatley, Nora D. Volkow, Joanna S. Fowler, Yu-Shin Ding, Jean Logan, Gene-Jack Wang et al.
Pages 433-465
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- Deborah C. Mash, Julie K. Staley
Pages 467-501
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Back Matter
Pages 503-518
About this book
Neurotransmission is a multicomponent process. Transmitters, released by neuronal activity, act on pre- and postsynaptic receptors, and many books detail advances in the receptor field. In addition, after their release from nerve endings, transmitters are removed from the neuronal vicinity by uptake into neuronal or glial cells by specific tra- porter proteins that have been studied intensely over the last 30 years; this information is scattered throughout numerous publishing vehicles. Therefore, the primary aim of this second edition of N- rotransmitter Transporters: Structure, Function, and Regulation is to offer a comprehensive picture of the characterization of neurotransmitter transporters and their biological roles. The transporter field has moved forward in stages. In the first phase, progress came from the use of substrate or blocker ligands selectively targeting transporters, the application of model systems allowing the study of transmitter tra- port shielded from storage, and the development of mathematical models for describing transport phenomena. In the second phase, roughly covering the last decade, advances in DNA techniques allowed the cloning of numerous genes coding for different transporter proteins. In the current, third stage, a wealth of information is being accumulated in studies relating transporter structure with function, experiments addressing regulation by posttranslational transfor- tion, investigations into transport modulation by trafficking processes and genomic influences, characterization of channel properties of tra- porters by electrophysiological approaches, and the creation of transgenic animals under- or overexpressing a given transporter protein.
Reviews
From Reviews of the first edition...
"...highly informative and useful..."-Trends in Neurosciences
Editors and Affiliations
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Department of Biomedical and Therapeutic Sciences, University of Illinois College of Medicine, Peoria, USA
Maarten E. A. Reith
