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Selective Estrogen Receptor Modulators

Research and Clinical Applications

  • Book
  • © 2002

Overview

Editors:
  1. Andrea Manni

    1. Division of Endocrinology, Diabetes, and Metabolism, Milton S. Hershey Medical Center, Pennsylvania State University College of Medicine, Hershey, USA

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  2. Michael F. Verderame

    1. Division of Endocrinology, Diabetes, and Metabolism, Milton S. Hershey Medical Center, Pennsylvania State University College of Medicine, Hershey, USA

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Part of the book series: Contemporary Endocrinology (COE)

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Table of contents (20 chapters)

  1. Front Matter

    Pages i-x
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  2. Molecular Mechanisms of Estrogen Receptor Function

    1. Front Matter

      Pages 1-1
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    2. Structure and Function of the Estrogen Receptor

      • Stefan Nilsson, Jan-Ã…ke Gustafsson
      Pages 3-18

    3. Ligand-Induced Conformational Changes in Estrogen Receptors-α and -β

      • Elizabeth A. Allegretto
      Pages 19-28

    4. Expression and Function of Estrogen Receptors-α and -β

      • Jonathan Lindzey
      Pages 29-56

    5. SERM Modulation of Gene Expression

      • Paul Webb
      Pages 57-76

    6. Crosstalk Between Estrogen Receptors and Growth Factor Signaling

      • Douglas Yee, Carol A. Lange
      Pages 77-95

  3. Tissue-Specific Effects of Estrogens and SERMs

    1. Front Matter

      Pages 97-97
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    2. Direct Estrogen Effects on the Cardiovascular System

      • Munish K. Goyal, Suzanne Oparil
      Pages 99-119

    3. Estrogens and the Brain

      • Bruce S. McEwen, Phyllis M. Wise, Stanley Birge
      Pages 121-144

  4. Preclinical Studies

    1. Front Matter

      Pages 145-145
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    2. Insights into the Molecular Mechanism of SERMs Through New Laboratory Models

      • Csaba Gajdos, James Zapf, V. Craig Jordan
      Pages 147-165

    3. Third- and Fourth-Generation SERMs

      • Fernand Labrie, Claude Labrie, Alain Bélanger, Jacques Simard
      Pages 167-187

  5. Organ Specific Effects of Estrogens and SERMs

    1. Front Matter

      Pages 189-189
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    2. SERMs’ Effect on the Neuroendocrine System and the Reproductive Organs

      • Nanette F. Santoro, Peter Kovacs
      Pages 191-206

    3. Epidemiology of Cardiovascular Disease in Women

      • Jacques E. Rossouw
      Pages 207-222

    4. SERMs Effects on Cardiovascular Risk Factors and Disease

      • Richard R. Love
      Pages 223-236

    5. Estrogen and the Skeleton

      • Michael Kleerekoper, Ashish Verma
      Pages 237-243

    6. Effects of SERMs on Bone in Clinical Studies

      • Aurelie Fontana, Pierre D. Delmas
      Pages 245-254

    7. Estrogens and SERMs

      • Alan J. Lerner
      Pages 255-264
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Keywords

About this book

Experimental and clinical researchers from a wide range of disciplines present a wealth of fresh scientific information on the biochemistry, molecular biology, pharmacology, and clinical activity of SERMs. The basic science chapters of the book focus-with an eye to the development of the ideal SERM-on the complex mechanisms of estrogen action, including ligand-dependent conformational changes in alpha and beta, and the recruitment of co-activators and co-repressors which modulate the estrogen receptor transcriptional activity and contribute to its crosstalk with growth factor signaling. The clinical presentation reviews the data accumulated on currently available SERMs, primarily tamoxifen and raloxifene, in cancer treatment and prevention, as well as their effects on the reproductive, vascular, skeletal, and central nervous systems. A tentative approach to menopause-related health issues is also provided for women with and without a previous diagnosis of localized breast cancer.

Reviews

"...this book is densely packed with data will be valuable for investigators in the field as well as those new to this area. There are many details of interest to the molecular endocrinologist. The clinical information is also intriguing for the clinician who needs to know how to apply the SERMs in the management of postmenopausal problems." - Oncology

"Selective Estrogen Receptor Modulators: Research and Clinical Application is an indispensable resource for evaluating the use of SERM potential alternatives to estrogens. The book synthesizes the current understanding of SERM at the levels of molecular mechanisms and clinical applications and provides a precise and balanced view of ongoing research and future developments. Clearly written and supported by informative illustrations, it is aimed at a specialized audience and should be particularly useful to researchers and clinicians eager to advance their knowledge of these so-called 'designer estrogens'. Selective Estrogen Receptor Modulators is an excellent collection of timely reviews. Its major strength is combining basic and clinical studies in a thorough account of current knowledge about estrogens and SERM." -Trends in Endocrinology and Metabolism

Editors and Affiliations

  • Division of Endocrinology, Diabetes, and Metabolism, Milton S. Hershey Medical Center, Pennsylvania State University College of Medicine, Hershey, USA

    Andrea Manni, Michael F. Verderame

Bibliographic Information

  • Book Title: Selective Estrogen Receptor Modulators

  • Book Subtitle: Research and Clinical Applications

  • Editors: Andrea Manni, Michael F. Verderame

  • Series Title: Contemporary Endocrinology

  • DOI: https://doi.org/10.1007/978-1-59259-157-2

  • Publisher: Humana Totowa, NJ

  • eBook Packages: Springer Book Archive

  • Copyright Information: Humana Press Inc. 2002

  • Hardcover ISBN: 978-0-89603-912-4Published: 18 January 2002

  • Softcover ISBN: 978-1-4684-9665-9Published: 12 December 2012

  • eBook ISBN: 978-1-59259-157-2Published: 18 January 2002

  • Series ISSN: 2523-3785

  • Series E-ISSN: 2523-3793

  • Edition Number: 1

  • Number of Pages: X, 374

  • Topics: Endocrinology

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