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Molecular Pathology of the Prions

  • Book
  • © 2001

Overview

Editors:
  1. Harry F. Baker

    1. Department of Experimental Psychology, MRC Comparative Cognition Team, School of Clinical Veterinary Medicine, Cambridge

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    You can also search for this editor in PubMed   Google Scholar

Part of the book series: Methods in Molecular Medicine (MIMM, volume 59)

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Table of contents (14 protocols)

  1. Front Matter

    Pages i-xii
    Download chapter PDF

  2. What Would Thomas Henry Huxley Have Made of Prion Diseases?

    • Rosalind M. Ridley
    Pages 1-16

  3. Prion Protein as Copper-Binding Protein at the Synapse

    • Hans A. Kretzschmar, Tobias Tings, Axel Madlung, Armin Giese, Jochen Herms
    Pages 17-30

  4. A Function for the Prion Protein?

    • David R. Brown, Ian M. Jones
    Pages 31-50

  5. Prion Protein Peptide

    • David R. Brown
    Pages 51-70

  6. Characterization of Bovine Spongiform Encephalopathy and Scrapie Strains/Isolates by Immunochemical Analysis of PrPSc

    • Martin H. Groschup, Frauke Junghans, Martin Eiden, Thorsten Kuczius
    Pages 71-83

  7. Differential Targeting of Neurons by Prion Strains

    • Stephen J. DeArmond
    Pages 85-110

  8. Transgenic Studies of Prion Diseases

    • Glenn C. Telling
    Pages 111-127

  9. Prions: From Neurografts to Neuroinvasion

    • Markus Glatzel, Sebastian Brandner, Michael A. Klein, Adriano Aguzzi
    Pages 129-147

  10. Cellular and Transgenic Models of Familial Prion Diseases

    • David A. Harris, Roberto Chiesa, Antonio Migheli, Pedro Piccardo, Bernardino Ghetti
    Pages 149-161

  11. Central Nervous System Inflammation and Prion Disease Pathogenesis

    • Samar Betmouni, V. Hugh Perry
    Pages 163-179

  12. The Electroneuropathology of Prion Disease

    • J. Richard Greene
    Pages 181-197

  13. Transmissible Spongiform Encephalopathy Neurobiology and Ultrastructure Suggests Extracellular PrPSc Conversion Consistent with Classical Amyloidosis

    • Martin Jeffrey, Jan R. Fraser
    Pages 199-221

  14. Conformation as Therapeutic Target in the Prionoses and Other Neurodegenerative Conditions

    • Thomas Wisniewski, Einar M. Sigurdsson, Pierre Aucouturier, Blas Frangione
    Pages 223-236

  15. Prions of Yeast From Cytoplasmic Genes to Heritable Amyloidosis

    • Reed B. Wickner, Herman K. Edskes, Kimberly L. Taylor, Marie-Lise Maddelein, Hiromitsu Moriyama, B. Tibor Roberts
    Pages 237-267

  16. Back Matter

    Pages 269-279
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About this book

Internationally recognized investigators review the latest developments in, and novel approaches to, understanding the prion protein and prion diseases at the molecular level. Utilizing a variety of cutting-edge techniques, these distinguished scientists seek to define the normal function of a prion protein, to detect and measure the early immune response to prion disease, and to discover possible therapeutic targets. They also use transgenic mice and new electrophysiological investigations to elucidate the pathogenetic mechanisms involved in prion diseases. State-of-the-art and richly insightful, Molecular Pathology of the Prions captures for basic and clinical neuropathologists the latest developments and approaches to understanding the pathogenesis of prion diseases, and by analogy suggests possible research techniques for the more common proteinopthies, such as Alzheimer's and Parkinson's diseases.

Editors and Affiliations

  • Department of Experimental Psychology, MRC Comparative Cognition Team, School of Clinical Veterinary Medicine, Cambridge

    Harry F. Baker

Bibliographic Information

  • Book Title: Molecular Pathology of the Prions

  • Editors: Harry F. Baker

  • Series Title: Methods in Molecular Medicine

  • DOI: https://doi.org/10.1385/1592591345

  • Publisher: Humana Totowa, NJ

  • eBook Packages: Springer Protocols

  • Copyright Information: Humana Press 2001

  • Hardcover ISBN: 978-0-89603-924-7Published: 13 July 2001

  • Softcover ISBN: 978-1-61737-252-0Published: 09 November 2010

  • eBook ISBN: 978-1-59259-134-3Published: 02 February 2008

  • Series ISSN: 1543-1894

  • Series E-ISSN: 1940-6037

  • Edition Number: 1

  • Number of Pages: XII, 279

  • Topics: Pathology

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