The Neuronal Environment

1. Front Matter

   Pages i-x

   PDF

2. Neuronal Activity and Its Dependence on the Microenvironment

   1. Front Matter

      Pages 1-1

      PDF

   2. Central Nervous System Microenvironment and Neuronal Excitability

      • Stephen Dombrowski, Imad Najm, Damir Janigro

      Pages 3-24

   3. Neuronal Energy Requirements

      • Avital Schurr

      Pages 25-54

3. Brain Microenvironment

   1. Front Matter

      Pages 55-55

      PDF

   2. Plasticity of Extracellular Space

      • Eva Syková

      Pages 57-81

   3. Transmitter-Receptor Mismatches in Central Dopamine, Serotonin, and Neuropeptide Systems

      • Anders Jansson, Laurent Descarries, Virginia Cornea-Hébert, Mustapha Riad, Daniel Vergé, Mircea Bancila et al.

      Pages 83-108

   4. The Extracellular Matrix in Neural Development, Plasticity, and Regeneration

      • Jeremy Garwood, Nicolas Heck, Franck Rigato, Andreas Faissner

      Pages 109-158

   5. Homeostatic Properties of Astrocytes

      • Wolfgang Walz, Bernhard H. J. Juurlink

      Pages 159-185

   6. Glutamate-Mediated Astrocyte-Neuron Communication in Brain Physiology and Pathology

      • Micaela Zonta, Giorgio Carmignoto

      Pages 187-209

   7. Axonal Conduction and Myelin

      • Jeffery D. Kocsis

      Pages 211-231

   8. Coupling of Blood Flow to Neuronal Excitability

      • Albert Gjedde

      Pages 233-257

4. Brain Macroenvironment

   1. Front Matter

      Pages 259-259

      PDF

   2. Choroid Plexus and the Cerebrospinal-Interstitial Fluid Systems

      • Roy O. Weller

      Pages 261-275

   3. The Blood-Brain Barrier

      • Richard F. Keep

      Pages 277-307

   4. Circumventricular Organs

      • James W. Anderson, Alastair V. Ferguson

      Pages 309-339

   5. Glial Linings of the Brain

      • Marc R. Del Bigio

      Pages 341-375

5. Immune System-Neuron Interactions

   1. Front Matter

      Pages 377-377

      PDF

   2. Microglia in the CNS

      • Sophie Chabot, V. Wee Yong

      Pages 379-400

   3. Invasion of Ischemic Brain by Immune Cells

      • Hiroyuki Kato, Takanori Oikawa

      Pages 401-417

Leading neuroscience researchers offer a fresh perspective on neuronal function by examining all its many components-including their pertubation during major disease states-and relate each element to neuronal demands. Topics range from the dependency of neurons on metabolic supply, as well as on both ion and transmitter homeostasis, to their close interaction with the myelin sheath. Also addressed are the astrocytic signaling system that controls synaptic transmission, the extracellular matrix and space as communication systems, the role of blood flow regulation in neuronal demand and in blood-brain barrier function, and inflammation and the neuroimmune system. Insightful and integrative, The Neuronal Environment: Brain Homeostasis in Health and Disease demonstrates a clear new understanding that neurons do not work in isolation, that they need constant interactions with other brain components to process information, and that they are not the only information processing system in the brain.

• Flow
• Nervous System
• dopamine
• information processing
• neurons
• neuroscience
• physiology
• regulation

"This book is a timely collection of reviews of fundamental processes in the compartments and chemical components of the cerebral micro-environments...its contents prove rewarding reading for the neuroclinician." - Clinical Neurology and Neurosurgery

"The book targets researchers, graduate students, and educators who face constant challenges on how to modify the external environment of a specific neuron in order to obtain specific behavioral results. The author is a credible authority on the subject but I think the scope of the book has an audience beyond that proposed by the author. Neurology and neurosurgery residents would also find it useful to read this book in order to better understand the mechanisms of control of the central nervous system...This is a good contribution to the field of neuroscience. Besides the initial aim signaled by the authors, I would extend the list of readers to neurology and neurosurgery residents, who are daily questioned on the genetic-physiologic correlation of diseases dealt with on a daily basis." -Doody's Health Sciences Book Review Journal

"...not just a textbook on neuroscience, as readers might imagine from the book title, but rather an essential guide for experts, beginners and students in the field of cell biology and pharmacology...written by experts who have made major contributions in their field..." - Journal of Chemical Neuroanatomy

"...this volume is not just a textbook on neuroscience, as readers might imagine from the book title, but rather an essential guide for exerts, beginners and students in the field of cell biology and pharmacology...written by experts who have made major contributions in their field..." - Journal of Chemical Neuroanatomy

"Once one begins to read in greater depth, it becomes clear that this volume is not just a textbook on neuroscience, as readers might imagine from the book title, but rather an essential guide for experts, beginners and students in the field of cell biology and pharmacology...written by experts who have made major contributions in their field...this book, besides being an excellent learning tool, is to enjoy." -Elsevier

• Department of Physiology, University of Saskatchewan, Saskatoon, Canada

  Wolfgang Walz

Policies and ethics