Neuroglia in the Aging Brain

1. Front Matter

   Pages i-xiii

   PDF

2. Cellular and Molecular Changes of Aged and Reactive Astrocytes

   1. Front Matter

      Pages 1-1

      PDF

   2. Neuromorphological Changes in Neuronal and Neuroglial Populations of the Cerebral Cortex in the Aging Rat

      • Maria Angeles Peinado, Manuel Martinez, Maria Jesus Ramirez, Adoracion Quesada, Juan Angel Pedrosa, Concepcion Iribar et al.

      Pages 3-16

   3. Diversity in Reactive Astrocytes

      • Sudarshan K. Malhotra, Theodor K. Shnitka

      Pages 17-33

   4. Astrocytic Reaction After Traumatic Brain Injury

      • Jesús Boya, J. L. Calvo, Angel López-Carbonell, José E. García-Mauriño

      Pages 35-56

3. Neuron-Glia Intercommunication

   1. Front Matter

      Pages 57-57

      PDF

   2. Astrocytes In Situ Exhibit Functional Neurotransmitter Receptors

      • Marilee K. Shelton, Ken D. McCarthy

      Pages 59-76

   3. Glia and Extracellular Space Diffusion Parameters in the Injured and Aging Brain

      • Eva Syková

      Pages 77-98

   4. Intercellular Diffusional Coupling between Glial Cells in Slices from the Striatum

      • Brigitte Hamon, Jacques Glowinski, Christian Giaume

      Pages 99-112

   5. Glial Cell Involvement in Brain Repair and the Effects of Aging

      • Elizabeth A. Howes, Peter J. S. Smith

      Pages 113-134

   6. ATP Signaling in Schwann Cells

      • Thierry Amédée, Aurore Colomar, Jonathan A. Coles

      Pages 135-153

4. Neurotrophins, Growth Factors, and Neurohormones in Aging and Regeneration

   1. Front Matter

      Pages 155-155

      PDF

   2. Gliosis Growth Factors in the Adult and Aging Rat Brain

      • Gérard Labourdette, Françoise Eclancher

      Pages 157-178

   3. Role of Fibroblast Growth Factor-2 in Astrogliosis

      • John F. Reilly

      Pages 179-198

   4. Trophins as Mediators of Astrocyte Effects in the Aging and Regenerating Brain

      • Judith Lackland, Cheryl F. Dreyfus

      Pages 199-216

   5. Responses in the Basal Forebrain Cholinergic System to Aging

      • Zezong Gu, J. Regino Perez-Polo

      Pages 217-244

   6. Effects of Estrogens and Thyroid Hormone on Development and Aging of Astrocytes and Oligodendrocytes

      • Kevin Higashigawa, Alisa Seo, Nayan Sheth, Giorgios Tsianos, Hogan Shy, Latha Malaiyandi et al.

      Pages 245-256

5. Metabolic Changes

   1. Front Matter

      Pages 257-257

      PDF

   2. Neurotoxic Injury and Astrocytes

      • Michael Aschner, Richard M. LoPachin

      Pages 259-274

   3. Ammonium Ion Transport in Astrocytes

      • Neville Brookes

      Pages 275-288

A distinguished panel of internationally recognized neuroscientists comprehensively review the involvement of and changes in glial cells both during the normal aging process and in the major disorders of old age. Topics range from the cellular and molecular changes that occur with aging-especially aging-associated activation of astrocytes and microglia and its relation to neuronal injury and repair-to neuron-glia intercommunication. The contributors show how glial signals may be modulated by hormones, growth factors, neurotransmitters, intracellular metabolism, and intercellular exchanges, as well as by aging of the blood-brain barrier.

• Alzheimer
• ELIZA
• Parkinson
• age
• aging
• anatomy
• cortex
• forebrain

Foreword by Paola S. Timiras, md, phd, University of California at Berkeley, Berkeley, CA

Overall, this carefully edited book organized its contents with a shrewd mind to bring out importance of glial cell function in the CNS vis-a-vis its functional unit, the neurons...This book with helpful diagrams and illustrations, and with excellent coverage of literature is not only useful for the beginners in neuroscience, but is an excellent reference material for gerontologists and researchers in neurological disorders. - Journal of Chemical Neuroanatomy

• UCLA Mental Retardation Research Center, Los Angeles, USA

  Jean S. Vellis

Policies and ethics