Transgenics in Endocrinology

1. Front Matter

   Pages i-x

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2. Germline Genetic Engineering Techniques in Endocrinology

   • Albert S. Y. Chang, Michael J. Reardon, Francesco J. DeMayo

   Pages 1-18

3. The Transgenic Mouse in Studies of Mammalian Sexual Differentiation

   • Deanne J. Whitworth, Richard R. Behringer

   Pages 19-39

4. The In Vivo Function of Müllerian-Inhibiting Substance During Mammalian Sexual Development

   • Yuji Mishina

   Pages 41-59

5. Control of Ovarian Function

   • Julia A. Elvin, Martin M. Matzuk

   Pages 61-89

6. Mouse Models to Study the Pituitary-Testis Interplay Leading to Regulated Gene Expression

   • Emiliana Borrelli, T. Rajendra Kumar, Paolo Sassone-Corsi

   Pages 91-114

7. Functional Analysis of the Bcl2 Gene Family in Transgenic Mice

   • Andrea J. Ross, Grant R. MacGregor

   Pages 115-145

8. The Role of the C-Kit/Kit Ligand Axis in Mammalian Gametogenesis

   • Peter J. Donovan, Maria P. de Miguel

   Pages 147-163

9. Gene Knockout Approaches to Steroidogenesis

   • Tomonobu Hasegawa, Liping Zhao, Kathleen M. Caron, Morag Young, Keith L. Parker

   Pages 165-172

10. The Progesterone Receptor Knockout Mouse Model

    • John P. Lydon, Selma Soyal, Bert W. O’Malley, Preeti M. Ismail

    Pages 173-204

11. Knockout and Transgenic Mouse Models that Have Contributed to the Understanding of Normal Mammary Gland Development

    • Tiffany N. Seagroves, Jeffrey M. Rosen

    Pages 205-229

12. Prolactin and the Prolactin Receptor

    • Nelson D. Horseman

    Pages 231-244

13. Transgenic Models for Oxytocin and Vasopressin

    • Larry J. Young, Thomas R. Insel

    Pages 245-260

14. Glycoprotein Hormones

    • Ruth A. Keri, John H. Nilson

    Pages 261-295

15. Genetic Approaches to the Study of Pituitary Follicle-Stimulating Hormone Regulation

    • Daniel J. Bernard, Teresa K. Woodruff

    Pages 297-317

16. Transgenic Analysis of the Proopiomelanocortin Neuroendocrine System

    • Malcolm J. Low, Marcelo Rubinstenin, E. Cheng Chan

    Pages 319-337

17. Overexpression and Targeted Disruption of Genes Involved in the Control of Growth, Food Intake, and Obesity

    • Andrzej Bartke, Michael Michalkiewicz

    Pages 339-370

18. Insulin and Insulin-Like Growth Factors

    • Carolyn A. Bondy, Domenico Accili

    Pages 371-384

19. Use of Transgenic Animals in Skeleton Biology

    • Thomas Günther, Mary Jo Doherty, Gerard Karsenty

    Pages 385-399

20. Transgenic Mouse Models of Prostate Cancer

    • Robert J. Matusik, Naoya Masumori, Tania Thomas, Thomas Case, Manik Paul, Susan Kasper et al.

    Pages 401-425

A panel of expert clinical and basic investigators summarize the state-of-the-art in the use of transgenic technology in a broad range of endocrinological applications. Up-to-date and comprehensive, Transgenics in Endocrinology reviews the most recent developments in the analysis of endocrine physiology and its pathologies through mouse models, and provides a host of creative approaches to understand better the complex processes that are characteristic of hormonal systems.

• growth factor
• insulin
• insulin-like
• physiology
• prolactin
• protein hormones

"The three editors have done a wonderful job in getting experts in the field to review their respective areas for publication in one book. . .Basic scientists in endocrinology will find this an important book as it puts together in one book areas that they might not otherwise be able to find summarized so well. Clinical scientists and clinicians will welcome the book for the insights into endocrine mechanisms. . .The index is very helpful as a resource to determine if a particular hormone or factor has been discussed in the book." -Doody's Health Sciences Book Review Journal

"I found the chapter on skeleton biology particularly fascinating. This provides an excellent review of processes and genes involved in bone pattering and development...this is a fascinating text and a great read." -The Endocrinologist

• Departments of Pathology, Molecular and Cellular Biology, and Molecular and Human Genetics, Baylor College of Medicine, Houston, USA

  Martin M. Matzuk

• Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, USA

  Chester W. Brown

• Departments of Pathology, and Molecular and Cellular Biology, Baylor College of Medicine, Houston, USA

  T. Rajendra Kumar

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