Vaccine Adjuvants

1. Front Matter

   Pages i-x

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2. An Overview of Adjuvant Use

   • Robert Edelman

   Pages 1-27

3. Harmful and Beneficial Activities of Immunological Adjuvants

   • Duncan E. S. Stewart-Tull

   Pages 29-48

4. Freund's Adjuvants

   • Erik B. Lindblad

   Pages 49-63

5. Aluminum Compounds as Vaccine Adjuvants

   • Rajesh K. Gupta, Bradford E. Rost

   Pages 65-89

6. Poly(Lactide-Coglycolide) Microparticles As Vaccine Adjuvants

   • Derek T. O’ Hagan, Manmohan Singh

   Pages 91-103

7. Poly(Methyl Methacrylate) Nanoparticles As Vaccine Adjuvants

   • Jörg Kreuter

   Pages 105-119

8. Aqueous Formulation of Adjuvant-Active Nonionic Block Copolymers

   • Charles W. Todd, Mark J. Newman

   Pages 121-136

9. Liposomes As Immunological Adjuvants and Vaccine Carriers

   • Gregory Gregoriadis, Brenda McCormack, Mia Obrenovic, Yvonne Perrie, Roghieh Saffie

   Pages 137-150

10. Immunopotentiating Reconstituted Influenza Virosomes (IRIVs)

    • Reinhard Glück

    Pages 151-178

11. Cochleates for Induction of Mucosal and Systemic Immune Responses

    • Susan Gould-Fogerite, Raphael J. Mannino

    Pages 179-196

12. Virus-like Particles As Vaccine Adjuvants

    • Sarah C. Gilbert

    Pages 197-209

13. The Adjuvant MF59: A 10-Year Perspective Gary Ott, Ramachandran Radhakrishnan,

    • Jia-Hwa Fang, Maninder Hora

    Pages 211-228

14. Preparation of the Syntex Adjuvant Formulation (SAF, SAF-m, and SAF-1)

    • Deborah M. Lidgate

    Pages 229-237

15. The ISCOM™ Technology

    • Karin Lövgren-Bengtsson, Bror Morein

    Pages 239-258

16. QS-21 Adjuvant

    • Charlotte Read Kensil

    Pages 259-271

17. MPL® Immunostimulant: Adjuvant Formulations

    • J. Terry Ulrich

    Pages 273-282

18. Cytokines As Vaccine Adjuvants: The Use of Interleukin-2

    • Martin A. Giedlin

    Pages 283-297

19. DNA As an Adjuvant

    • David C. Neujahr, David S. Pisetsky

    Pages 299-313

20. Transcutaneous Immunization

    • Gregory M. Glenn, Tanya Scharton-Kersten, Russell Vassell

    Pages 315-326

Derek T. O'Hagan and a team of expert vaccinologists and pharmacologists thoroughly describe the preparation, characterization, and evaluation of a wide range of alternative vaccine adjuvants for use in preclinical studies. Each chapter carefully reviews a single adjuvant, and suggests why a specific adjuvant might be preferred for a given antigen, depending on what type of immune response is desired. Alternate adjuvant choices are also presented so that researchers can choose those most efficacious for their specific purpose. Comprehensive and highly practical, Vaccine Adjuvants: Preparation Methods and Research Protocols provides an effective guide to making and using vaccine adjuvants. By closely following directions from the book, today's researchers will be able optimally to induce specific immune responses against different types of antigens and to selectively manipulate the immune response in a favorable way.

"This book is a welcome addition to the rapidly expending field of immunological adjuvant. The editor has done an outstanding job in persuading experts both from industry and academic institutions to contribute in a wide range of topics on vaccine adjuvants. This book should be valuable for researchers working in the area of vaccine development for infectious diseases, cancer, autoimmune diseases, and modulation of reproduction and animal productivity.Three chapters, An Overview of Adjuvant Use; Harmful and Beneficial Activities of Immunological Adjuvants; and Transcutaneous Immunization, provide excellent basic information that should be of interest to both new and established researchers in the area of vaccine development....Overall, this is an excellent comprehensive book on vaccine adjuvants."-Pharmaceutical Research

"...provides a very good overview on the mechanisms, procedures for applications and partial comparisons of different adjuvants, starting from classical Freund's adjuvants and aluminum hydroxide/phosphate to poly (lactide-coglycolide) microparticles, poly(methyl methacrylate) nanoparticles, non-ionic block copolymers, liposomes, including immunostimulatory complexes....The volumes is likely to be widely consulted in many areas of experimental and clinical microbiological sciences where protection of the population from infection by vaccines is the main aim of the research." - MicroBiology Today

• Chiron Corporation, Emeryville

  Derek T. O’Hagan

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