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Principles of Molecular Rheumatology

  • Book
  • © 2000

Overview

Editors:
  1. George C. Tsokos

    1. Walter Reed Army Institute of Research, Silver Spring, USA
      Uniformed Services University of the Health Sciences, Bethesda, USA

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Part of the book series: Current Molecular Medicine (CMM, volume 1)

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Table of contents (34 chapters)

  1. Front Matter

    Pages i-xiii
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  2. Molecular Mechanisms in Rheumatic Diseases

    1. Front Matter

      Pages 1-1
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    2. Genetics

      • Peter K. Gregersen
      Pages 3-14

    3. Viruses

      • Andras Perl
      Pages 15-33

    4. Apoptosis

      • John D. Mountz, Hui-Chen Hsu, Huang-Ge Zhang, Tong Zhou
      Pages 35-58

    5. Humoral Response

      • Gary S. Gilkeson
      Pages 59-74

    6. T-Cell Signaling

      • Gary A. Koretzky, Erik J. Peterson
      Pages 75-85

    7. Adhesion and Costimulatory Molecules

      • Vassiliki A. Boussiotis, Gordon J. Freeman, Lee M. Nadler
      Pages 87-108

    8. Transcription Factors

      • Henry K. Wong
      Pages 109-125

    9. Immune Complexes

      • Mark H. Wener
      Pages 127-144

    10. Complement

      • V. Michael Holers
      Pages 145-160

    11. Eicosanoids and Other Bioactive Lipids

      • Leslie J. Crofford
      Pages 161-173

    12. Collagens

      • Sergio A. Jiménez
      Pages 175-196

  3. Cellular Mechanisms in Rheumatic Diseases

    1. Front Matter

      Pages 197-197
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    2. T-Lymphocytes

      • Nilamadhab Mishra, Gary M. Kammer
      Pages 199-211

    3. B-Lymphocytes

      • Robert F. Ashman
      Pages 213-223

    4. Monocytes and Macrophages

      • James M. K. Chan, Sharon M. Wahl
      Pages 225-242

    5. Polymorphonuclear Cells

      • Michael H. Pillinger, Pamela B. Rosenthal, Bruce N. Cronstein
      Pages 243-257

    6. Synoviocytes

      • David E. Yocum
      Pages 259-265

    7. Chondrocytes

      • Tariq M. Haqqi, Donald D. Anthony, Charles J. Malemud
      Pages 267-277
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Keywords

About this book

George Tsokos and a panel of authoritative clinicians and researchers synthesize the latest findings from across cell and molecular biology with the basic principles of rheumatology to create the first textbook of molecular rheumatology. These established experts describe the biochemical mechanisms by which apoptosis, cell signaling, complement, lipids, and viruses contribute to disease expression, and detail both immune and nonimmune cell function in rheumatic diseases. Their review of the major rheumatic diseases integrates the cellular, biochemical, and molecular biological mechanisms that are important in rheumatic disease pathogenesis. Path-breaking and illuminating, Principles of Molecular Rheumatology expands the envelope of clinical understanding to reveal the biological roots underlying rheumatologic disease, as well as the nature and roles of the powerful new therapeutics now emerging for its optimal treatment.

Reviews

"Unlike previous classical textbooks of rheumatology in which the clinical and therapeutic approaches to rheumatic disease are discussed, this one is unique in the contributors' ability to integrate the clinical approach to rheumatic disease with the latest biochemical, cellular, and molecular mechanisms at play in these disorders. This approach allows clinical rheumatologists to gain a better understanding of the cellular and molecular biology that underlies the diseases we treat and the therapeutics we use to treat these disorders.."-Doody's Health Science Book Review Journal

"It contains many figures of good quality." - Journal of Endocrine Genetics

"Unlike previous classical textbooks of rheumatology in which the clinical and therapeutic approaches to rheumatic disease are discussed, this one is unique in the contributors' ability to integrate the clinical approach to rheumatic disease with the latest biochemical, cellular, and molecular mechanisms at play in these disorders. This approach allows clinical rheumatologists to gain a better understanding of the cellular and molecular biology that underlies the diseases we treat and the therapeutics we use to treat these disorders." - Doody Publishing

Editors and Affiliations

  • Walter Reed Army Institute of Research, Silver Spring, USA

    George C. Tsokos

  • Uniformed Services University of the Health Sciences, Bethesda, USA

    George C. Tsokos

Bibliographic Information

  • Book Title: Principles of Molecular Rheumatology

  • Editors: George C. Tsokos

  • Series Title: Current Molecular Medicine

  • DOI: https://doi.org/10.1007/978-1-59259-018-6

  • Publisher: Humana Totowa, NJ

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer Science+Business Media New York 2000

  • Hardcover ISBN: 978-0-89603-773-1Published: 24 July 2000

  • Softcover ISBN: 978-1-61737-182-0Published: 19 November 2010

  • eBook ISBN: 978-1-59259-018-6Published: 24 July 2000

  • Series ISSN: 1566-5240

  • Series E-ISSN: 1875-5666

  • Edition Number: 1

  • Number of Pages: XIII, 542

  • Number of Illustrations: 57 b/w illustrations

  • Topics: Rheumatology

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