Therapeutic Interventions in the Complement System

1. Front Matter

   Pages i-x

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2. Complement as a Regulatory and Effector Pathway in Human Diseases

   • V. Michael Holers

   Pages 1-32

3. The Regulation of C1 Activation and Its Role in Disease

   • C. Erik Hack

   Pages 33-56

4. Inhibition of Complement Serine Proteases as a Therapeutic Strategy

   • Sthanam V. L. Narayana, Y. Sudhakara Babu, John E. Volanakis

   Pages 57-74

5. Complement Inhibitors Targeting C3, C4, and C5

   • Arvind Sahu, Dimitrios Morikis, John D. Lambris

   Pages 75-112

6. Complement Anaphylatoxins (C3a, C4a, C5a) and Their Receptors (C3aR, C5aR/CD88) as Therapeutic Targets in Inflammation

   • Rick A. Wetsel, Jens Kildsgaard, David L. Haviland

   Pages 113-153

7. Modulation of Disease Using Recombinant Human Endogenous Complement Inhibitors

   • Richard J. Quigg

   Pages 155-170

8. Roles of Integrins CR3 and CR4 in Disease and Therapeutic Strategies

   • Yu Xia, Gordon D. Ross

   Pages 171-204

9. Inhibition of Complement in the Membrane Attack Pathway

   • B. Paul Morgan

   Pages 205-224

10. Evaluation of Complement Inhibitors

    • Patricia C. Giclas

    Pages 225-236

11. Use of Animal Models to Define Complement Functions

    • Peter A. Ward, Boris J. Czermak, Markus Huber-Lang, Katherine Diehl, Hans P. Friedl

    Pages 237-253

12. Back Matter

    Pages 255-259

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A team of expert investigators and clinical researchers comprehensively review complement's basic biology, its role in disease, methods to measure its activity, and strategies for its inhibition in patients. Each chapter focuses on a specific area of basic and applied complement biology, spelling out the activation pathways and complement receptors. Informative animal models are discussed in detail, including the relative values of each model and the important interspecies differences that can distort the interpretation of preclinical studies. The emphasis throughout is on the pros and cons of the therapeutic use of recombinant complement inhibitors in specific diseases. Cutting-edge and innovative, Therapeutic Interventions in the Complement System highlights for today's researcher and biotechnologist effective strategies of drug discovery and development that are producing valuable new complement inhibitors for the treatment of a wide variety of clinically important diseases.

• biology
• clinical research
• diseases
• drug
• drug discovery
• inflammation
• research

• University of Pennsylvania School of Medicine, Philadelphia, USA

  John D. Lambris

• University of Colorado Health Sciences Center, Denver, USA

  V. Michael Holers

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