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Matrix Metalloproteinase Inhibitors in Cancer Therapy

  • Book
  • © 2001

Overview

Editors:
  1. Neil J. Clendeninn

    1. Corporate V.P., Clinical Affairs, Agouron Pharmaceuticals Inc., San Diego, USA

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    You can also search for this editor in PubMed   Google Scholar

  2. Krzysztof Appelt

    1. Department of Research Pharmacology, Agouron Pharmaceuticals Inc., San Diego, USA

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

Part of the book series: Cancer Drug Discovery and Development (CDD&D)

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Table of contents (10 chapters)

  1. Front Matter

    Pages i-xiii
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  2. Biology and Regulation of the Matrix Metalloproteinases

    • Mark D. Sternlicht, Lisa M. Coussens, Thiennu H. Vu, Zena Werb
    Pages 1-37

  3. Substrate Specificity of MMPs

    • Hideaki Nagase
    Pages 39-66

  4. The Tissue Inhibitors of Metalloproteinases (TIMPs)

    • Dylan R. Edwards
    Pages 67-84

  5. Matrix Metalloproteinases in Cancer

    • Barbara Fingleton, Lynn M. Matrisian
    Pages 85-112

  6. Hydroxamic Acid Matrix Metalloproteinase Inhibitors

    • Peter D. Brown, Alan H. Davidson, Alan H. Drummond, Andrew Gearing, Mark Whittaker
    Pages 113-142

  7. Prinomastat

    • David R. Shalinsky, Bhasker Shetty, Yazdi Pithavala, Steve Bender, Anthony Neri, Stephanie Webber et al.
    Pages 143-173

  8. A Potent Nonpeptidic Matrix Metalloproteinase Inhibitor

    • G. Clemens, B. Hibner, R. Humphrey, H. Kluender, S. Wilhelm
    Pages 175-192

  9. D1927 and D2163

    • A. D. Baxter, J. B. Bird, R. Bannister, R. Bhogal, D. T. Manallack, R. W. Watson et al.
    Pages 193-221

  10. Research on MMP Inhibitors with Unusual Scaffolds

    • Frank Grams, Hans Brandstetter, Richard A. Engh, Dagmar Glitz, Hans-Willi Krell, Valeria Livi et al.
    Pages 223-243

  11. Matrix Metalloproteinase Inhibitors

    • Michael R. Niesman
    Pages 245-254

  12. Back Matter

    Pages 255-262
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Keywords

About this book

Cutting-edge investigators review the current status of the entire field, from the biology of MMPs through the current clinical studies. The authors include many leading scientists from pharmaceutical companies who present all the latest concepts and results on the preferred design strategies for MMP inhibitors, their molecular mechanisms, and their substrates. In addition, they fully describe their personal research on specific MMP inhibitors, detailing vanguard design strategies, their in vitro activity, the outcome of animal model studies and, where available, their toxicology, safety, efficacy in human clinical trials.
Comprehensive and state-of-the-art, Matrix Metalloproteinase Inhibitors in Cancer Therapy offers basic and clinical investigators alike a richly informative summary of all the latest research on these powerful new drugs, and their high promise as emerging cancer therapeutics.

Editors and Affiliations

  • Corporate V.P., Clinical Affairs, Agouron Pharmaceuticals Inc., San Diego, USA

    Neil J. Clendeninn

  • Department of Research Pharmacology, Agouron Pharmaceuticals Inc., San Diego, USA

    Krzysztof Appelt

Bibliographic Information

  • Book Title: Matrix Metalloproteinase Inhibitors in Cancer Therapy

  • Editors: Neil J. Clendeninn, Krzysztof Appelt

  • Series Title: Cancer Drug Discovery and Development

  • DOI: https://doi.org/10.1007/978-1-59259-011-7

  • Publisher: Humana Totowa, NJ

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer Science+Business Media New York 2001

  • Hardcover ISBN: 978-0-89603-668-0Published: 17 September 2000

  • Softcover ISBN: 978-1-61737-123-3Published: 29 July 2011

  • eBook ISBN: 978-1-59259-011-7Published: 17 September 2000

  • Series ISSN: 2196-9906

  • Series E-ISSN: 2196-9914

  • Edition Number: 1

  • Number of Pages: XIII, 262

  • Number of Illustrations: 26 b/w illustrations, 3 illustrations in colour

  • Topics: Oncology

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