Vascular Disease and Injury

1. Front Matter

   Pages i-xvii

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2. Acute Mechanical Injury and Vascular Repair

   1. Front Matter

      Pages 1-1

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   2. Mechanical Injury in Normal and Atherosclerotic Rabbit Iliac Arteries

      • Frederick G. P. Welt, Elazer R. Edelman, Campbell Rogers

      Pages 3-17

   3. The Porcine Model of Coronary Restenosis

      • Robert S. Schwartz, Birgit Kantor, David R. Holmes Jr.

      Pages 19-41

   4. Atherosclerotic Porcine Coronary Stent Model

      • Andrew J. Carter

      Pages 43-51

   5. Nonhuman Primate Models of Arterial Injury and Repair

      • Mark Nedelman, Christopher Horvath, Campbell Rogers

      Pages 53-60

   6. Experimental Models of Arteriovenous Grafting

      • Afshin Ehsan, Michael J. Mann, Victor J. Dzau

      Pages 61-78

   7. Wire Denudation and Ligation Models of the Mouse Carotid Artery

      • Volkhard Lindner

      Pages 79-86

   8. Endothelial Denudation and Arterial Dilation in the Mouse

      • Zhiping Chen, Campbell Rogers, Daniel I. Simon

      Pages 87-94

   9. Vascular Photochemical Injury in the Mouse

      • Daniel T. Eitzman, Randal J. Westrick

      Pages 95-101

   10. Mouse Model of Transluminal Femoral Artery Injury

       • Ernane D. Reis, Susan S. Smyth, Barry S. Coller

       Pages 103-113

3. Models of Arterial Thrombosis

   1. Front Matter

      Pages 115-115

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   2. A Murine Model of Arterial Injury and Thrombosis

      • William P. Fay, Andrew C. Parker, Yanhong Zhu

      Pages 117-125

   3. Folts Cyclic Flow Animal Model for Studying in Vivo Platelet Activity and Platelet Interactions with Damaged Arterial Walls

      • John D. Folts

      Pages 127-145

4. Chronic Atherosclerotic Models

   1. Front Matter

      Pages 147-147

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   2. Mouse Models of Atherosclerosis

      • Wulf Palinski, Claudio Napoli, Peter D. Reaven

      Pages 149-174

   3. Rabbit Models of Atherosclerosis

      • Masanori Aikawa, Yoshihiro Fukumoto, Elena Rabkin, Peter Libby

      Pages 175-191

   4. Atherosclerosis in Nonhuman Primates

      • David Kritchevsky, Robert J. Nicolosi

      Pages 193-204

5. Vascular Disease in Transplanted Vessels

   1. Front Matter

      Pages 205-205

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   2. Murine Carotid Loop Model of Transplant Vascular Disease

      • Victor Chengwei Shi, Jennifer L. Hoover

      Pages 207-214

A panel of expert clinical researchers offer a practical guide to the key animal models used in vascular disease. These experts examine critical issues related to vascular disease and injury in five major areas: acute mechanical injury and vascular repair, arterial thrombosis, chronic atherosclerosis, vascular disease in transplanted vessels, and vascular disease in systemic and pulmonary arterial hypertension. Up-to-date and highly practical, Vascular Disease and Injury: Preclinical Studies provides a comprehensive review that not only illuminates the current status of cardiovascular research, but also offers vascular biologists and cardiologists a detailed how-to guide to the development of the many powerful new therapeutics now emerging.

• Stent
• anesthesia
• atherosclerosis
• cardiovascular
• hypertension
• thrombosis
• transplantation
• vascular disease

• Cardiovascular Division, Brigham and Women’s Hospital, Boston, USA

  Daniel I. Simon, Campbell Rogers

Policies and ethics