Overview
- Probes the molecular pathways and the intersection of signaling networks which are frequently deregulated in human cancers
- Describes EGF receptor in a tumor tissue specific context
- Illustrates the many ways in which EGF receptors contribute to abnormal survival and migration signaling in cancer cells and to epithelial-to-mesenchymal transition and metastasis
Part of the book series: Cancer Drug Discovery and Development (CDD&D)
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Table of contents (23 chapters)
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EGFR Signaling Networks
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EGFR in Tumorigenesis and EGFR Tyrosine Kinase Inhibitors in Cancer Therapy
Keywords
About this book
Reviews
From the reviews:
"This book describes the state of EGFR antagonist development and treatment modalities…. This will be of interest to those in academic research studying EGFR signaling and/or cancer. … This is an excellent reference for those focused on a particular aspect of EGFR signaling who are looking for a concise review. This is a timely review of an increasingly complex area of study." (James P. Luyendyk, Doody’s Review Service, January, 2009)
"This book bridges the basic and clinical progress in EGFR network in cancer therapy over 40 years of EGFR research. Due to the contributors’ basic science and clinical backgrounds, the book is … best suited for basic scientists, translational scientists, and oncologists who engage in EGFR associated research and clinical therapy at various levels. The book provides a comprehensive EGFR resource for researchers not only in basic biological fields but also in preclinical and clinical therapy … ." (Guolin Zhang and Eric B. Haura, Cancer Control, Vol. 16 (4), October, 2009)
“This book is a collection of articles from different authors organized into two sections. … a good and useful book for any medicinal chemist working in this field … . all chapters are well written, clear, and rather agreeable to read. … easily understood by even an inexperienced reader. … a useful introduction to the role of EGFR signaling networks in a large number of tumors for novice researchers, but it could also be considered in some way a reference text for more experienced ones.” (Adriano Martinelli, ChemBioChem, Vol. 5, 2010)
Editors and Affiliations
Bibliographic Information
Book Title: EGFR Signaling Networks in Cancer Therapy
Editors: John D. Haley, William John Gullick
Series Title: Cancer Drug Discovery and Development
DOI: https://doi.org/10.1007/978-1-59745-356-1
Publisher: Humana Totowa, NJ
eBook Packages: Medicine, Medicine (R0)
Copyright Information: Humana Press 2008
Hardcover ISBN: 978-1-58829-948-2Published: 25 September 2008
Softcover ISBN: 978-1-61737-853-9Published: 20 January 2011
eBook ISBN: 978-1-59745-356-1Published: 01 March 2009
Series ISSN: 2196-9906
Series E-ISSN: 2196-9914
Edition Number: 1
Number of Pages: XI, 395
Topics: Oncology, Cancer Research