Bacterial Genomes and Infectious Diseases

1. Front Matter

   Pages i-xiii

   PDF

2. Microbial Genomes

   • Voon Loong Chan

   Pages 1-19

3. Evolution and Origin of Virulence Isolates

   • Voon Loong Chan, Philip M. Sherman, Billy Bourke

   Pages 21-30

4. Genomic Approach to Understanding Infectious Disease Mechanisms

   • Voon Loong Chan, Philip M. Sherman, Billy Bourke

   Pages 31-39

5. Knockout and Disease Models in Toll-Like Receptor-Mediated Immunity

   • Huey-Lan Huang, Wen-Chen Yeh

   Pages 41-61

6. Campylobacter

   • John Kelly, Jean-Robert Brisson, N. Martin Young, Harold C. Jarrell, Christine M. Szymanski

   Pages 63-90

7. Genomics of Helicobacter Species

   • Zhongming Ge, David B. Schauer

   Pages 91-107

8. The Organization of Leptospira at a Genomic Level

   • Dieter M. Bulach, Torsten Seemann, Richard L. Zuerner, Ben Adler

   Pages 109-123

9. Listeria monocytogenes

   • Keith Ireton

   Pages 125-149

10. Mycobacterial Genomes

    • David C. Alexander, Jun Liu

    Pages 151-174

11. Mycoplasma

    • Yuko Sasaki

    Pages 175-190

12. Genome Comparisons of Diverse Staphylococcus aureus Strains

    • Martin J. McGavin

    Pages 191-212

13. Type III Secretion Systems in Yersinia pestis and Yersinia pseudotuberculosis

    • James B. Bliska, Michelle B. Ryndak, Jens P. Grabenstein

    Pages 213-226

14. Genomics and the Evolution of Pathogenic Vibrio cholerae

    • William S. Jermyn, Yvonne A. O’Shea, Anne Marie Quirke, E. Fidelma Boyd

    Pages 227-254

15. Future Directions of Infectious Disease Research

    • Philip M. Sherman, Billy Bourke, Voon Loong Chan

    Pages 255-264

16. Back Matter

    Pages 265-270

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The first bacterial genome, Haemophilus influenzae, was completely sequenced, annotated, and published in 1995. Today, more than 200 prokaryotic (archaeal and bacterial) genomes have been completed and over 500 prokaryotic genomes are in va- ous stages of completion. Seventeen eukaryotic genomes plus four eukaryotic chro- somes have been completed. The concept of achieving better understanding of an organism through knowledge of the complete genomic sequence was first demonstrated in 1978 when the first bacteriophage genome, X174, was sequenced. Complete genomic sequences of prokaryotes have led to a better understanding of the biology and evolution of the microbes, and, for pathogens, facilitated identification of new vaccine candidates, putative virulence genes, targets for antibiotics, new strategy for rapid diagnosis, and investigation of bacteria–host interactions and disease mec- nisms. Recent increased interest in microbial pathogens and infectious diseases is largely attributed to the re-emergence of infectious diseases like tuberculosis, emergence of new infectious diseases like AIDS and severe acute respiratory syndrome, the problem of an increasing rate of emergence of antibiotic-resistant variants of pathogens, and the fear of bioterrorism. Microbes are highly diverse and abundant in the biosphere. Less than 1% of these morphologically identified microbes can be cultured in vitro using standard techniques and conditions. With such abundance of microbes in nature, we can expect to see new variants and new species evolve and a small number will emerge as pathogens to humans.

• Microarray
• antibiotics
• bacteria
• bioinformatics
• genetics
• infectious
• infectious disease
• infectious diseases

"...should serve well those seeking a general introduction and overview of both the principles and application of microbial genomics to the study of infectious disease.  Clear explanations of what can often be viewed as a complex and confusing subject should make this a valuable resource in this important and rapidly advancing area of research." -Doody's Book Review, Weighted Numberical Score: 78 - 3 stars

• Department of Medical Genetics and Microbiology, University of Toronto, Toronto, Canada

  Voon L. Chan

• Department of Paediatrics Department of Laboratory Medicine and Pathobiology Hospital for Sick Children, University of Toronto, Toronto, Canada

  Philip M. Sherman

• Children’s Research Center, Our Lady’s Hospital for Sick Children, School of Medicine and Medical Science, Dublin, Ireland

  Billy Bourke

• Conway Institute for Biomolecular and Biomedical Research, University College, Dublin, Ireland

  Billy Bourke

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