Bone Metastasis

1. Front Matter

   Pages i-xiii

   PDF

2. Fundamental Concepts

   1. Front Matter

      Pages 1-1

      PDF

   2. Overview

      • Sadmeet Singh, Gurmit Singh

      Pages 3-12

   3. Parathyroid Hormone-Related Peptide and Malignancy

      • David Goltzman

      Pages 13-27

   4. Vitamin D and Vitamin D Analogs in Cancer Progression and Metastasis

      • Richard Kremer, Shafaat A. Rabbani

      Pages 29-57

   5. Role of TGF-β and IGF in Tumor Progression and Bone Metastases

      • Erin Giles, Gurmit Singh

      Pages 59-74

   6. Biologic and Therapeutic Implications of Osteomimicry and Epithelial-Mesenchymal Transition in Prostate Cancer

      • Wen-Chin Huang, Valerie Odero-Marah, Leland W. K. Chung

      Pages 75-86

   7. Roles of Immune-Cell-Derived Matrix Metalloproteinases in Tumor Growth and Metastasis

      • Kristina A. Szabo, Gurmit Singh

      Pages 87-106

   8. Contribution of Osteopontin to the Development of Bone Metastasis

      • Alison L. Allan, Alan B. Tuck, Vivien H. C. Bramwell, Theodore A. Vandenberg, Eric W. Winquist, Ann F. Chambers

      Pages 107-123

   9. Role of Interleukin-11 in Osteolytic Bone Metastasis

      • Ryan R. Simon, Martin K. Butcher, Stephen G. Shaughnessy

      Pages 125-132

   10. Cell Adhesion Molecules in Tumor Metastasis

       • Sujata Persad, Gurmit Singh

       Pages 133-146

   11. PTHrP and Cancer

       • Leonard J. Deftos, D. W. Burton, Randolph H. Hastings

       Pages 147-175

   12. Antithrombotics in Tumor Growth and Metastasis

       • Shaker A. Mousa

       Pages 177-187

3. Therapeutic Strategies

   1. Front Matter

      Pages 189-189

      PDF

   2. Challenges and Strategies in the Analysis of Multiple Events in Oncology

      • Pierre P. Major, Richard J. Cook

      Pages 191-199

   3. Integrins

      • Graham C. Parry, Fernando Doñate, Marian L. Plunkett, David E. Shaw, Steven Pirie-Shepherd, Andrew P. Mazar

      Pages 201-227

   4. Bone Metastasis and Pathological Fractures

      • Laurie A. McDuffee, Nigel Colterjohn, Gurmit Singh

      Pages 229-241

   5. Role of Photodynamic Therapy for Bone Metastasis

      • Shane Burch, Albert J. M. Yee

      Pages 243-253

   6. Docetaxel for Metastatic Cancer and Its Role in Combination Therapies for Advanced Prostate Cancer

      • Ellen K. Wasan, Martin Gleave, Karen Fang, Kim Chi, Gwyn Bebb, Lincoln Edwards et al.

      Pages 255-292

   7. Use of Tetracyclines for Bone Metastases

      • Eric Seidlitz, Zeina Saikali, Gurmit Singh

      Pages 293-303

A state-of-the-art review of the molecular underpinnings of bone-seeking cancers, current treatment approaches for them, and future therapeutic strategies. The authors illuminate the role of various autocrine, paracrine, and immunological factors involved in the progression and establishment of bone metastases, highlighting the physiological processes that lead to bone degradation, pain, angiogenesis, and dysregulation of bone turnover. They also discuss the various strategies that appear to have promise and are currently deployed in treatment or are at the experimental stage.

• angiogenesis
• bisphosphonates
• cancer
• cell
• hormones
• metastasis
• oncology
• pain
• prostate cancer
• tissue
• tumor
• tumor growth
• tumor progression

• Department of Pathology and Molecular Medicine/Juravinski Cancer Centre, McMaster University, Hamilton, Canada

  Gurmit Singh

• Calcium Research Laboratory, McGill University Health Centre, Montreal, Canada

  Shafaat A. Rabbani

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