Cardiovascular Genomics

1. Front Matter

   Pages i-xiii

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2. Genes and Polymorphisms in Cardiovascular Disease

   1. Front Matter

      Pages 1-1

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   2. Angiotensin II Receptor Polymorphisms and Hypertension

      • Bruno Baudin

      Pages 3-18

   3. Angiotensinogen Gene Polymorphisms and Hypertension

      • Ashok Kumar

      Pages 19-40

   4. Substitution Mapping

      • Bina Joe, Michael R. Garrett

      Pages 41-58

   5. Local Production of Angiotensinogen

      • Kamal Rahmouni, Curt D. Sigmund

      Pages 59-70

   6. Cardiovascular Pharmacogenomics

      • Julie A. Johnson, Larisa H. Cavallari

      Pages 71-93

   7. Genetic Polymorphisms and Response to HMG-CoA Reductase Inhibitors

      • Anke-Hilse Maitland-van der Zee, Olaf H. Klungel, Anthonius de Boer

      Pages 95-114

   8. Monogenic Causes of Heart Failure

      • Hideko Kasahara

      Pages 115-134

3. Gene Transfer for Combating Cardiovascular Disease

   1. Front Matter

      Pages 135-135

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   2. Gene Therapy vs Pharmacotherapy

      • Ryuichi Morishita

      Pages 137-156

   3. Molecular Therapeutic Approaches for Myocardial Protection

      • Alok S. Pachori, Luis G. Melo, Victor J. Dzau

      Pages 157-173

   4. Gene Transfer and the Cardiovascular System

      • William H. Miller, Stuart A. Nicklin, Andrew H. Baker, Anna F. Dominiczak

      Pages 175-196

   5. Kallikrein Gene Transfer in Hypertension, Cardiovascular and Renal Disease, and Stroke

      • Julie Chao, Lee Chao

      Pages 197-212

   6. Current and Future Novel Targets of Gene Therapy for Hypertension

      • Michael J. Katovich, Justin L. Grobe, Mohan K. Raizada

      Pages 213-246

   7. Application of Viral Gene Transfer in Studies of Neurogenic Hypertension

      • Sergey Kasparov, A. G. Teschemacher, Julian F. R. Paton

      Pages 247-268

   8. Vigilant Vectors

      • M. Ian Phillips, Yi Tang

      Pages 269-283

   9. Gene Therapy for Celebral Arterial Diseases

      • Yoshimasa Watanabe, Donald D. Heistad

      Pages 285-302

4. Regenerative Tissues for the Diseased Cardiovascular System

   1. Front Matter

      Pages 303-303

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   2. Therapeutic Angiogenesis and Vasculogenesis for Tissue Regeneration

      • Paolo Madeddu

      Pages 305-323

Recognized scientists and clinicians from around the world discuss the most recent molecular approaches to understanding the cardiovascular system in both health and disease. The authors focus on all components of the system, including blood vessels, heart, kidneys, and the brain, and cover disease states ranging from vascular and cardiac dysfunction to stroke and hypertension. The methods described for identifying the genes that cause susceptibility to cardiovascular diseases emphasize the possibility of discovering new drug targets. Authoritative and ground-breaking, Cardiovascular Genomics offers an unprecedented examination of both the cutting-edge scientific approaches now possible and the results obtained from them in the new science of cardiovascular genomics.

• Angiotensin II
• cardiovascular
• gene therapy
• genes
• hypertension

From the reviews:

"‘Cardiovascular Genomics’ provides an up to date account of genes that are important in cardiovascular health and disease. … For those who require a concise, well-researched and written collection on some of the ways that cardiovascular diseases are being tackled from the laboratory to the patient bedside, this book will provide an excellent choice in this fast paced area of research." (S. Loughna, Human Genetics, Vol. 121, 2007)

• Department of Physiology and Functional Genomics, University of Florida College of Medicine, Gainesville

  Mohan K. Rai

• Department of Physiology, School of Medical Sciences, University of Bristol, Bristol

  Julian F. R. Paton, Sergey Kasparov

• Department of Pharmacodynamics, University of Florida College of Pharmacy, Gainesville

  Michael J. Katovich

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