Portal Hypertension

1. Front Matter

   Pages i-xv

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2. Historical Perspective

   1. Front Matter

      Pages 1-1

      PDF

   2. Portal Hypertension

      • Adrian Reuben, Roberto J. Groszmann

      Pages 3-11

3. Pathobiology and Experimental Progress in Portal Hypertension

   1. Front Matter

      Pages 13-13

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   2. Anatomy and Vascular Biology of the Cells in the Portal Circulation

      • Massimo Pinzani, Francesco Vizzutti

      Pages 15-35

   3. Cell and Molecular Mechanisms of Increased Intrahepatic Resistance and Hemodynamic Correlates

      • Don C. Rockey

      Pages 37-50

   4. Molecular Mechanisms of Systemic Vasodilation and Hyperdynamic Circulatory State of Cirrhosis

      • Richard Moreau, Didier Lebrec

      Pages 51-64

   5. Mechanisms of Sodium Retention, Ascites Formation, and Renal Dysfunction in Cirrhosis

      • Andrés Cárdenas, Pere Ginès

      Pages 65-84

   6. Hepatic Hemodynamics in Portal Hypertension

      • W. Wayne Lautt, Zhi Ming

      Pages 85-97

   7. Neovascularization, Angiogenesis, and Vascular Remodeling in Portal Hypertension

      • Manuel Morales-Ruiz, Wladimiro Jiménez

      Pages 99-112

   8. Mechanisms of Cardiopulmonary Hemodynamics and Dysfunction in Portal Hypertension

      • Michael B. Fallon

      Pages 113-125

4. Methodology to Assess Portal Hypertension in Humans

   1. Front Matter

      Pages 127-127

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   2. Measurement of Hepatic Venous Pressure Gradient

      • G. Pomier-Layrargues, P.-Michel Huet

      Pages 129-144

   3. Evaluation of Portal Hemodynamics Using Indicator Dilution and Noninvasive Techniques

      • Juerg Reichen

      Pages 145-154

   4. Endoscopic Assessment of Portal Hypertension Including Variceal Pressure Measurements

      • Àngels Escorsell, Jaime Bosch

      Pages 155-164

5. Natural History and Treatment of Esophageal Varices

   1. Front Matter

      Pages 165-165

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   2. Clinical Features and Natural History of Variceal Hemorrhage

      • Juan G. Abraldes, Jaime Bosch

      Pages 167-181

   3. Management Strategies for the Prophylaxis and Treatment of Esophageal Variceal Rupture

      • Roberto de Franchis

      Pages 183-198

   4. Pharmacologic Therapy for Management of Esophageal Varices

      • Norman D. Grace, Richard S. Tilson

      Pages 199-219

   5. Endoscopic Treatment for Bleeding Esophageal Varices

      • John P. Cello

      Pages 221-234

A cutting-edge review of the latest findings on key scientific topics and the best strategies for evaluation and management of portal hypertension in the clinic. Writing in an easy-to-read style, the authors review its pathobiology, the progress being made in its experimental understanding, the methodologies to assess it in humans, the treatment of its complications (esophageal varices, ascites, and hepatorenal syndrome), and its treatment in special circumstances (during pregnancy, in children, or when the portal vein is blocked). They also provide in-depth coverage of the pros and cons of the various therapeutic choices available to the clinician managing patients with complicated portal hypertension.

• Ascites
• Esophageal varices
• Hepatic encephalopathy
• Hepatorenal syndrome
• Hyponatremia
• Neovascularization
• Portal vein thrombosis
• Stent
• Vasodilation
• hypertension
• hepatology

"...truly insightful...the book beautifully builds upon the molecular and biological machinery into an enhanced clinical understanding of portal hypertension complete with the most up-to-date treatment options." - Practical Gastroenterology

"...provides exceptional reading material encompassing a broad range of topics on basic and clinical aspecgts of portal hypertension...strongly recommended to researchers, practicing physicians, trainees, and others with an interest in this subject." Weighted Numerical Score: 96 - 4 Stars! - Doody's Health Science Book Review Journal

"...the ideal guide for those who want to deal with the clinical problems of portal hypertension in a modern and effective way." - Digestive and Liver Disease

• Division of Gastroenterology, Virginia Commonwealth Medical Center, Richmond

  Arun J. Sanyal

• GI Research Unit, Mayo Clinic, Rochester

  Vijay H. Shah

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