Natural Products

1. Front Matter

   Pages i-xiv

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2. Fundamental Issues Related to Natural Product-Based Drug Delivery

   1. Front Matter

      Pages 1-1

      PDF

   2. Natural Products and Drug Discovery

      • Arnold L. Demain, Lixin Zhang

      Pages 3-29

3. Strategies

   1. Front Matter

      Pages 31-31

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   2. Integrated Approaches for Discovering Novel Drugs From Microbial Natural Products

      • Lixin Zhang

      Pages 33-55

   3. Automated Analyses of HPLC Profiles of Microbial Extracts

      • José R. Tormo, Juan B. García

      Pages 57-75

   4. Manipulating Microbial Metabolites for Drug Discovery and Production

      • C. Richard Hutchinson

      Pages 77-93

   5. Improving Drug Discovery From Microorganisms

      • Chris M. Farnet, Emmanuel Zazopoulos

      Pages 95-106

   6. Developments in Strain Improvement Technology

      • Stephen B. del Cardayré

      Pages 107-125

4. Specific Groups of Drugs

   1. Front Matter

      Pages 127-127

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   2. The Discovery of Anticancer Drugs From Natural Sources

      • David J. Newman, Gordon M. Cragg

      Pages 129-168

   3. Case Studies in Natural-Product Optimization

      • Jian Hong, Shu-Hui Chen

      Pages 169-196

   4. Terpenoids As Therapeutic Drugs and Pharmaceutical Agents

      • Guangyi Wang, Weiping Tang, Robert R. Bidigare

      Pages 197-227

   5. Challenges and Opportunities in the Chinese Herbal Drug Industry

      • Wei Jia, Lixin Zhang

      Pages 229-250

   6. Arsenic Trioxide and Leukemia

      • Guo-Qiang Chen, Qiong Wang, Hua Yan, Zhu Chen

      Pages 251-272

5. Microbial Diversity

   1. Front Matter

      Pages 273-273

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   2. New Methods to Access Microbial Diversity for Small Molecule Discovery

      • Karsten Zengler, Ashish Paradkar, Martin Keller

      Pages 275-293

   3. Accessing the Genomes of Uncultivated Microbes for Novel Natural Products

      • Asuncion Martinez, Joern Hopke, Ian A. MacNeil, Marcia S. Osburne

      Pages 295-312

6. Specific Sources

   1. Front Matter

      Pages 313-313

      PDF

   2. New Natural-Product Diversity From Marine Actinomycetes

      • Paul R. Jensen, William Fenical

      Pages 315-328

A fresh examination of the past successes of natural products as medicines and their new future from both conventional and new technologies. High-performance liquid chromatography profiling, combinatorial synthesis, genomics, proteomics, DNA shuffling, bioinformatics, and genetic manipulation all now make it possible to rapidly evaluate the activities of extracts as well as purified components derived from microbes, plants, and marine organisms. The authors apply these methods to new natural product drug discoveries, to microbial diversity, to specific groups of products (Chinese herbal drugs, antitumor drugs from microbes and plants, terpenoids, and arsenic compounds), and to specific sources (the sea, rainforest, and endophytes). These new opportunities show how research and development trends in the pharmaceutical industry can advance to include both synthetic compounds and natural products, and how this paradigm shift can be more productive and efficacious.

• cancer
• drug
• drug delivery
• drug discovery
• research

From the reviews:

"Natural Products, Drug Discovery and Therapeutic Medicine timely shares the experience of renowned scientist from academy and industry working in the field. … a very comprehensive tool that will help everybody interested in the discovery of natural products. I highly recommend this book for those who want to understand the potential of drug development from natural products in the light of modern knowledge and technology as well as for individuals who want to understand history of pass successes in drug discovery from natural products." (Sonia Mesia-Vela, Phytomedicine, Vol. 13, 2006)

• Guangzhou Institute of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China

  Lixin Zhang

• SynerZ Pharmaceuticals Inc., Lexington

  Lixin Zhang

• Charles A. Dana Research Institute (R.I.S.E.), Drew University, Madison

  Arnold L. Demain

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