Vascular Dementia

1. Front Matter

   Pages i-xiii

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2. Introduction

   1. Front Matter

      Pages 1-1

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   2. The Aging Population and the Relevance of Vascular Dementia

      • Kelly L. Lange, Robert H. Paul

      Pages 3-5

   3. Clinical Forms of Vascular Dementia

      • Gustavo C. Román

      Pages 7-21

   4. The Neuropathologic Substrates of Vascular-Ischemic Dementia

      • Kurt A. Jellinger

      Pages 23-56

   5. Diagnosis of Vascular Dementia

      • José G. Merino, Vladimir Hachinski

      Pages 57-71

3. Basic Mechanisms of Vascular Dementia

   1. Front Matter

      Pages 73-73

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   2. Cerebral Hemodynamics in the Elderly

      • Jorge M. Serrador, William P. Milberg, Lewis A. Lipsitz

      Pages 75-86

   3. The CADASIL Syndrome and Other Genetic Causes of Stroke and Vascular Dementia

      • Stephen Salloway, Sophie Desbiens

      Pages 87-98

   4. Estrogen, the Cerebrovascular System, and Dementia

      • Sharon X. C. Yang, George A. Kuchel

      Pages 99-112

   5. Effects of Hypertension in Young Adult and Middle-Aged Rhesus Monkeys

      • Mark B. Moss, Elizabeth M. Jonak

      Pages 113-128

4. The Impact of Vascular Dementia on Cognitive, Psychiatric, and Daily Living

   1. Front Matter

      Pages 129-129

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   2. The Cognitive Profile of Vascular Dementia

      • Angela L. Jefferson, Adam M. Brickman, Mark S. Aloia, Robert H. Paul

      Pages 131-143

   3. Progression of Cognitive Impairments Associated With Cerebrovascular Disease

      • Sally Stephens, Raj Kalaria, Rose Anne Kenny, Clive Ballard

      Pages 145-156

   4. Neuropsychiatric Correlates of Vascular Injury

      • Anand Kumar, Helen Lavretsky, Ebrahim Haroon

      Pages 157-169

   5. Functional Impairment in Vascular Dementia

      • Patricia A. Boyle, Deborah Cahn-Weiner

      Pages 171-177

5. Neuroimaging of Vascular Dementia

   1. Front Matter

      Pages 179-179

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   2. Functional Brain Imaging of Cerebrovascular Disease

      • Ronald Cohen, Lawrence Sweet, David F. Tate, Marc Fisher

      Pages 181-209

   3. Contributions of Subcortical Lacunar Infarcts to Cognitive Impairment in Older Persons

      • Dan Mungas

      Pages 211-222

   4. White Matter Hyperintensities and Cognition

      • David J. Moser, Jason E. Kanz, Kelly D. Garrett

      Pages 223-229

A multidisciplinary survey of our current understanding of the biological and clinical aspects of vascular disease. The authors describe its basic mechanisms, its clinical characteristics, its pharmacological management, and the use of neuroimaging methods to investigate it. The complex relationship between VaD and AD is also fully explored with chapters on how these processes interact and how one disease may lower the threshold for clinical expression of the other.

• Alzheimer
• alzheimer's disease
• brain
• brain imaging
• cognition
• dementia
• neuroprotection

From the reviews:

"This book is an update on the link between cerebrovascular disease and dementia. … The book has several strengths. … The diagrams, images, and tables are generally thoughtful. … Overall, Vascular Dementia is a valuable textbook. After reviewing it, I felt as if I had been brought up to date on a variety of topics related to the disorder … . I would recommend the book to geriatricians, internists, and neurologists who care for elderly patients as well as to clinical researchers in geriatric neurology." (Carol F. Lippa, New England Journal of Medicine, June, 2005)

• Department of Psychiatry and Human Behavior, Brown Medical School, Providence

  Robert H. Paul, Ronald Cohen

• Department of Neurology, Memorial Hospital of Rhode Island, Pawtucket

  Brian R. Ott

• Department of Clinical Neurosciences, Brown Medical School, Providence

  Brian R. Ott, Stephen Salloway

• Department of Neurology, Butler Hospital, USA

  Stephen Salloway

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