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Bioinformatics and Drug Discovery

  • Book
  • © 2006

Overview

Editors:
  1. Richard S. Larson

    1. Department of Pathology, University of New Mexico School of Medicine, Albuquerque

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Part of the book series: Methods in Molecular Biology (MIMB, volume 316)

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Table of contents (15 protocols)

  1. Front Matter

    Pages i-x
    Download chapter PDF

  2. New Strategies in Drug Discovery

    • Eliot H. Ohlstein, Anthony G. Johnson, John D. Elliott, Anne M. Romanic
    Pages 1-11

  3. Basic Microarray Analysis

    • Scott A. Ness
    Pages 13-33

  4. From Microarray to Biological Networks

    • Xiwei Wu, T. Gregory Dewey
    Pages 35-48

  5. Microarray Analysis in Drug Discovery and Clinical Applications

    • Siqun Wang, Qiong Cheng
    Pages 49-65

  6. Ontology-Driven Approaches to Analyzing Data in Functional Genomics

    • Francisco Azuaje, Fatima Al-Shahrour, Joaquin Dopazo
    Pages 67-86

  7. Gene Evolution and Drug Discovery

    • James O. McInerney, Caroline S. Finnerty, Jennifer M. Commins, Gayle K. Philip
    Pages 87-109

  8. Standardization of Microarray and Pharmacogenomics Data

    • Casey S. Husser, Jeffrey R. Buchhalter, O. Scott Raffo, Amnon Shabo, Steven H. Brown, Karen E. et al.
    Pages 111-157

  9. Clinical Applications of Bioinformatics, Genomics, and Pharmacogenomics

    • Omer Iqbal, Jawed Fareed
    Pages 159-177

  10. Protein Interactions Probed With Mass Spectrometry

    • Suma Kaveti, John R. Engen
    Pages 179-197

  11. Discovering New Drug-Targeting Sites on Flexible Multidomain Protein Kinases

    • Thomas K. Harris
    Pages 199-225

  12. Nuclear Magnetic Resonance-Based Screening Methods for Drug Discovery

    • Laurel O. Sillerud, Richard S. Larson
    Pages 227-289

  13. Receptor-Binding Sites

    • Darren R. Flower
    Pages 291-358

  14. In Silico Protein Design

    • Bassil I. Dahiyat
    Pages 359-374

  15. Chemical Database Preparation for Compound Acquisition or Virtual Screening

    • Cristian G. Bologa, Marius M. Olah, Tudor I. Oprea
    Pages 375-388

  16. Bioinformatics Platform Development

    • Alexis S. Ivanov, Alexander V. Veselovsky, Alexander V. Dubanov, Vladlen S. Skvortsov
    Pages 389-431

  17. Back Matter

    Pages 433-444
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Keywords

About this book

A collection of readily reproducible bioinformatic methods to advance the drug discovery process from gene identification to protein modeling to the identification of specific drug candidates. The authors demonstrate these techniques, including microarray analysis, the analysis of genes as potential drug targets, virtual screening and in silico protein design, and cheminformatics, in a variety of practical situations. Because these technologies are still emergent, each chapter contains an extended introduction that explains the theory and application of the technology and techniques described.

Reviews

"...succeeds admirably in illuminating the latest interdisciplinary techniques being applied to drug discovery, including target selection and validation, receptor binding site characterization and binding prediction, and use for new lead discovery." - Journal of Medicinal Chemistry

Editors and Affiliations

  • Department of Pathology, University of New Mexico School of Medicine, Albuquerque

    Richard S. Larson

Bibliographic Information

  • Book Title: Bioinformatics and Drug Discovery

  • Editors: Richard S. Larson

  • Series Title: Methods in Molecular Biology

  • DOI: https://doi.org/10.1385/1592599648

  • Publisher: Humana Totowa, NJ

  • eBook Packages: Springer Protocols

  • Copyright Information: Humana Press 2006

  • Hardcover ISBN: 978-1-58829-346-6Published: 01 October 2005

  • Softcover ISBN: 978-1-61737-509-5Published: 09 December 2010

  • eBook ISBN: 978-1-59259-964-6Published: 04 February 2008

  • Series ISSN: 1064-3745

  • Series E-ISSN: 1940-6029

  • Edition Number: 1

  • Number of Pages: X, 444

  • Number of Illustrations: 103 b/w illustrations

  • Topics: Pharmacy

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