Drug Metabolism and Transport

1. Front Matter

   Pages i-x

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2. Renal Cytochrome P450s and Flavin-Containing Monooxygenases

   • Adnan A. Elfarra

   Pages 1-18

3. Experimental Approaches for the Study of Cytochrome P450 Gene Regulation

   • Hollie I. Swanson, Susan D. Kraner, Soma S. Ray, Martin Hoagland, Earl D. Thompson, Xinyu Zheng et al.

   Pages 19-44

4. Insulin and Growth Factor Signaling

   • Sang K. Kim, Kimberley J. Woodcroft, Raymond F. Novak

   Pages 45-83

5. Catalytic Function and Expression of Glutathione Transferase Zeta

   • Philip G. Board, M. W. Anders, Anneke C. Blackburn

   Pages 85-107

6. Glucuronidation of Fatty Acids and Prostaglandins by Human UDP-Glucuronosyltransferases

   • Anna Radominska-Pandya, Joanna M. Little, Arthur Bull

   Pages 109-132

7. Transcriptional Regulation of UDP-Glucuronosyltransferases

   • Anna Radominska-Pandya, Peter I. Mackenzie, Wen Xie

   Pages 133-171

8. Phenotypic and Genotypic Characterization of N-Acetylation

   • Craig K. Svensson, David W. Hein

   Pages 173-195

9. Methods and Approaches to Study Metabolism and Toxicity of Acetaminophen

   • Sam A. Bruschi

   Pages 197-232

10. Modulation of Drug Metabolism and Antiviral Therapies

    • Bernhard H. Lauterburg

    Pages 233-251

11. Modulation of Thiols and Other Low-Molecular-Weight Cofactors

    • Charles V. Smith

    Pages 253-271

12. Multidrug Resistance Proteins and Hepatic Transport of Endo- and Xenobiotics

    • Phillip M. Gerk, Mary Vore

    Pages 273-289

13. Structural Determinants of Folate and Antifolate Membrane Transport by the Reduced Folate Carrier

    • Wei Cao, Larry H. Matherly

    Pages 291-318

14. Glutathione Transport in the Kidneys

    • Lawrence H. Lash

    Pages 319-339

15. Human Cytosolic Sulfotransferases

    • Charles N. Falany

    Pages 341-378

16. Back Matter

    Pages 379-387

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A compendium of proven experimental approaches and strategies for studying the bioactivation, detoxification, tissue distribution, and elimination of xenobiotics in the metabolism and/or transport of various chemicals. The authors address several of the major drug metabolizing systems, including the cytochrome P450 family, flavin-containing monooxygenases, glutathione, S-transferase, glucuronidation, N-acetylation, and sulfotransferases. Additional chapters present novel approaches to the study of: signaling pathways in the regulation of drug metabolism enzymes, how the modulation of thiols and other low molecular-weight cofactors can alter drug metabolism, and how modulation of drug metabolism pathways can influence antiviral therapy.

• cytochrome P450
• detoxification
• drug
• drug resistance
• metabolism
• research
• resistance
• toxicity
• toxicology
• xenobiotic
• xenobiotics

"With the diverse subject matter and the wealth of information on techniques and research strategies there is likely to be something in this book to interest those from PhD students to more experienced researchers." -Newsletter of the British Toxicological Society

• Department of Pharmacology, Wayne State University School of Medicine, Detroit

  Lawrence H. Las

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