Overview
- Editors:
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Lawrence H. Las
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Department of Pharmacology, Wayne State University School of Medicine, Detroit
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Table of contents (14 protocols)
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- Hollie I. Swanson, Susan D. Kraner, Soma S. Ray, Martin Hoagland, Earl D. Thompson, Xinyu Zheng et al.
Pages 19-44
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- Sang K. Kim, Kimberley J. Woodcroft, Raymond F. Novak
Pages 45-83
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- Philip G. Board, M. W. Anders, Anneke C. Blackburn
Pages 85-107
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- Anna Radominska-Pandya, Joanna M. Little, Arthur Bull
Pages 109-132
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- Anna Radominska-Pandya, Peter I. Mackenzie, Wen Xie
Pages 133-171
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- Craig K. Svensson, David W. Hein
Pages 173-195
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- Phillip M. Gerk, Mary Vore
Pages 273-289
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- Wei Cao, Larry H. Matherly
Pages 291-318
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Back Matter
Pages 379-387
About this book
A compendium of proven experimental approaches and strategies for studying the bioactivation, detoxification, tissue distribution, and elimination of xenobiotics in the metabolism and/or transport of various chemicals. The authors address several of the major drug metabolizing systems, including the cytochrome P450 family, flavin-containing monooxygenases, glutathione, S-transferase, glucuronidation, N-acetylation, and sulfotransferases. Additional chapters present novel approaches to the study of: signaling pathways in the regulation of drug metabolism enzymes, how the modulation of thiols and other low molecular-weight cofactors can alter drug metabolism, and how modulation of drug metabolism pathways can influence antiviral therapy.
Reviews
"With the diverse subject matter and the wealth of information on techniques and research strategies there is likely to be something in this book to interest those from PhD students to more experienced researchers." -Newsletter of the British Toxicological Society
Editors and Affiliations
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Department of Pharmacology, Wayne State University School of Medicine, Detroit
Lawrence H. Las
