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Functional Genomics

  • Book
  • © 2003

Overview

Editors:
  1. Michael J. Brownstein

    1. Laboratory of Genetics, NIMH/NHGRI, National Institutes of Health, Rockville

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    You can also search for this editor in PubMed   Google Scholar

  2. Arkady B. Khodursky

    1. Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, St. Paul

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

Part of the book series: Methods in Molecular Biology (MIMB, volume 224)

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Table of contents (15 protocols)

  1. Front Matter

    Pages i-xii
    Download chapter PDF

  2. Fabrication of cDNA Microarrays

    • Charlie C. Xiang, Michael J. Brownstein
    Pages 1-7

  3. Nylon cDNA Expression Arrays

    • George Jokhadze, Stephen Chen, Claire Granger, Alex Chenchik
    Pages 9-29

  4. Plastic Microarrays

    • Alexander Munishkin, Konrad Faulstich, Vissarion Aivazachvili, Claire Granger, Alex Chenchik
    Pages 31-54

  5. Preparing Fluorescent Probes for Microarray Studies

    • Charlie C. Xiang, Michael J. Brownstein
    Pages 55-60

  6. Escherichia coli Spotted Double-Strand DNA Microarrays

    • Arkady B. Khodursky, Jonathan A. Bernstein, Brian J. Peter, Virgil Rhodius, Volker F. Wendisch, Daniel P. Zimmer
    Pages 61-78

  7. Isolation of Polysomal RNA for Microarray Analysis

    • Yoav Arava
    Pages 79-87

  8. Parallel Analysis of Gene Copy Number and Expression Using cDNA Microarrays

    • Jonathan R. Pollack
    Pages 89-97

  9. Genome-wide Mapping of Protein-DNA Interactions by Chromatin Immunoprecipitation and DNA Microarray Hybridization

    • Jason D. Lieb
    Pages 99-109

  10. Statistical Issues in cDNA Microarray Data Analysis

    • Gordon K. Smyth, Yee Hwa Yang, Terry Speed
    Pages 111-136

  11. Experimental Design to Make the Most of Microarray Studies

    • M. Kathleen Kerr
    Pages 137-147

  12. Statistical Methods for Identifying Differentially Expressed Genes in DNA Microarrays

    • John D. Storey, Robert Tibshirani
    Pages 149-157

  13. Detecting Stable Clusters Using Principal Component Analysis

    • Asa Ben-Hur, Isabelle Guyon
    Pages 159-182

  14. Clustering in Life Sciences

    • Ying Zhao, George Karypis
    Pages 183-218

  15. A Primer on the Visualization of Microarray Data

    • Paul Fawcett
    Pages 219-234

  16. Microarray Databases

    • Gavin Sherlock, Catherine A. Ball
    Pages 235-248

  17. Back Matter

    Pages 249-258
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About this book

This collection of robust, readily reproducible methods for microarray-based studies includes expert guidance in the optimal data analysis and informatics. On the methods side are proven techniques for monitoring subcellular RNA localization en masse, for mapping chromosomes at the resolution of a single gene, and for surveying the steady-state genome-wide distribution of DNA binding proteins in vivo. For those workers dealing with massive data sets, the book discusses the methodological aspects of data analysis and informatics in the design of microarray experiments, the choice of test statistic, and the assessment of observational significance, data reduction, and clustering.

Reviews

"....a good book, and it will be useful to microarray workers in their effots." - Journal of Chemical Neuroanatomy

Editors and Affiliations

  • Laboratory of Genetics, NIMH/NHGRI, National Institutes of Health, Rockville

    Michael J. Brownstein

  • Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, St. Paul

    Arkady B. Khodursky

Bibliographic Information

  • Book Title: Functional Genomics

  • Editors: Michael J. Brownstein, Arkady B. Khodursky

  • Series Title: Methods in Molecular Biology

  • DOI: https://doi.org/10.1385/159259364X

  • Publisher: Humana Totowa, NJ

  • eBook Packages: Springer Protocols

  • Copyright Information: Humana Press 2003

  • Hardcover ISBN: 978-1-58829-291-9Published: 13 March 2003

  • Softcover ISBN: 978-1-61737-474-6Published: 09 December 2010

  • eBook ISBN: 978-1-59259-364-4Published: 03 February 2008

  • Series ISSN: 1064-3745

  • Series E-ISSN: 1940-6029

  • Edition Number: 1

  • Number of Pages: XII, 260

  • Topics: Cell Biology

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