Platelet Function

1. Front Matter

   Pages i-xi

   PDF

2. Platelet Physiology

   1. Front Matter

      Pages 1-1

      PDF

   2. Platelet Physiology

      • Martin Quinn

      Pages 3-20

   3. Platelet Integrins and Signaling

      • Karlheinz Peter

      Pages 21-42

   4. Platelet Adhesion

      • Brian Savage, Zaverio M. Ruggeri

      Pages 43-69

   5. Structure-Function of the Platelet Cytoskeleton

      • Elaine L. Bearer

      Pages 71-114

   6. Platelets and Inflammation

      • Meinrad Gawaz

      Pages 115-147

   7. Platelet Signal-Dependent Protein Synthesis

      • Stephan Lindemann, Thomas M. McIntyre, Stephen M. Prescott, Guy A. Zimmerman, Andrew S. Weyrich

      Pages 149-174

   8. Phosphoproteomics of Human Platelets

      • Katrin Marcus, Helmut E. Meyer

      Pages 175-198

3. Assessing Platelet Function

   1. Front Matter

      Pages 199-199

      PDF

   2. Platelet Function Studies

      • Dermot Cox

      Pages 201-222

   3. Platelet Function Under Flow

      • José A. López, Ian del Conde, Jing-Fei Dong

      Pages 223-246

   4. Pharmacodynamics of GPIIb-IIIa Receptor Blockade

      • Lisa K. Jennings, Melanie M. White

      Pages 247-266

   5. Prostanoid Generation in Platelet Function

      • Bianca Rocca, Carlo Patrono

      Pages 267-281

   6. Platelets and Prothrombin

      • Michael Kalafatis, Emil Negrescu, Tatiana Byzova, Edward F. Plow

      Pages 283-300

   7. Markers of Platelet Activation and Granule Secretion

      • Alan D. Michelson, Mark I. Furman

      Pages 301-314

   8. Genomic and Proteomic Analysis of Platelets

      • Andrew Maree, James McRedmond

      Pages 315-331

4. Clinical Applications

   1. Front Matter

      Pages 333-333

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   2. Antiplatelet Agents

      • Jacqueline Saw, David J. Moliterno

      Pages 335-367

   3. Assessing Platelet Function in Clinical Trials

      • Neal Kleiman

      Pages 369-384

A cutting-edge review of the latest findings on the complexities of platelet function and the various means of inhibiting platelet clot formation. The authors delineate an up-to-date picture of platelet biology and describe methods for assessing platelet function, including the commonly used platelet aggregation, thromboxane production, procoagulant function, platelet function under flow, and the expression of platelet activation markers. The focus is both on the technology and the outcome of research on platelets, including the fast developing fields of proteomics and genomics and their application to platelet research. The clinical applications of the various methods for the assessment of platelet function in vivo, as well as antiplatelet therapy, are fully discussed.

• antiplatelet therapy
• pharmacodynamics
• physiology
• platelet
• thromboxane

From the reviews:

"...an outstanding book for those who want a concise review of platelet function and its relevance to thrombotic disorders and current pharmacology." - Circulation

"...a very useful book for anyone interested in the fundamentals of platelet function, platelet biomarkers, techniques for activation measurement, and thrombotic disorders." - Circulation

"This book is directed to the attention of clinicians practicing clinical and or laboratory medicine, basic scientists interested in platelet physiology, pharmocologists focusing on cardiovascular drugs, and teachers of medical students and physicians in training. … The most advanced investigative techniques are presented in separate chapters to explore platelet membrane receptors, signal-dependant translation in platelets and for identifying products that regulate thrombosis and inflammation. … a relatively small book, but with 397 pages of pertinent and practical knowledge from major professionals in the field." (Harry L. Messmore and William H. Wehrmacher, Clinical and Applied Thrombosis/Hemostasis, Vol. 12 (1), January, 2006)

• Department of Cardiology, St. Vincent’s University Hospital, Dublin, Ireland

  Martin Quinn

• University College Dublin, Dublin, Ireland

  Desmond Fitzgerald

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