Overview
- Editors:
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Stuart N. Isaacs
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Division of Infectious Diseases, University of Pennsylvania, Philadelphia
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Table of contents (24 protocols)
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- Maríia M. Lorenzo, Inmaculada Galindo, Rafael Blasco
Pages 15-30
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- Chelsea M. Byrd, Dennis E. Hruby
Pages 31-40
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- Mohamed Ragaa Mohamed, Edward G. Niles
Pages 41-50
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- Xiao-Dan Yao, David H. Evans
Pages 51-64
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- Ernest S. Smith, Shuying Shi, Maurice Zauderer
Pages 65-75
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- Caroline Staib, Ingo Drexler, Gerd Sutter
Pages 77-99
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- Girish J. Kotwal, Melissa-Rose Abrahams
Pages 101-112
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- Hermann Meyer, Inger K. Damon, Joseph J. Esposito
Pages 119-133
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- Steven S. Broyles, Marcia Kremer
Pages 135-142
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- Paula Traktman, Kathleen Boyle
Pages 169-185
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- Mansun Law, Geoffrey L. Smith
Pages 187-203
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- Bruce T. Seet, Grant McFadden
Pages 219-242
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- Richard Harrop, Matthew G. Ryan, Hana Golding, Irina Redchenko, Miles W. Carroll
Pages 243-265
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- Nia Tatsis, Gomathinayagam Sinnathamby, Laurence C. Eisenlohr
Pages 267-287
About this book
The Right Book at the Right Time The poxviruses comprise a family of complex DNA viruses that replicate in the cytoplasm of vertebrate or invertebrate cells. Of the eight recognized g- era of vertebrate poxviruses, those belonging to the orthopoxvirus genus have been most intensively studied. This group includes variola virus, the agent of smallpox, as well as cowpox virus and vaccinia virus. Jenner’s original sma- pox vaccine, described in 1798, consisted of live cowpox virus, but vaccinia virus later replaced it (1). There has been speculation as to the origin of v- cinia virus; the most likely idea is that it is a separate species, possibly ori- nally isolated from a horse, and is now extinct or rare in nature (2). Recent genome sequencing studies confirm the distinctness of variola virus, cowpox virus, and vaccinia virus and also their very close genetic relationship, which accounts for the cross protection of smallpox vaccines. The novelty of the smallpox vaccine can be readily appreciated by the time it took, about 80 years, before the next live vaccine against rabies was developed, and another 50 years for the yellow fever vaccine. Moreover, the eradication of smallpox in 1977 stands as a unique medical achievement. Because of its historical role, sma- pox vaccination contributed greatly to present concepts of infectious disease, immunity, and pathogenesis. Less well known, however, are the many other “firsts” for vaccinia virus.
Reviews
From the foreword...
"The right book at the right time." -Bernard Moss
"...a collection of up-to-date protocols...the book is intended for virologists devoted to poxvirus research and scientists in vaccine research and some biotechnology area." - Chemotherapy
Editors and Affiliations
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Division of Infectious Diseases, University of Pennsylvania, Philadelphia
Stuart N. Isaacs
