Cancer Gene Therapy

1. Front Matter

   Pages i-xii

   PDF

2. Cancer Gene Therapy

   • Malcolm K. Brenner

   Pages 1-8

3. The Genetic Basis of Cancer

   • Akseli Hemminki, Kari Hemminki

   Pages 9-18

4. Tumor Suppressor Gene Replacement for Cancer

   • Jack A. Roth, Susan F. Grammer

   Pages 19-33

5. Antisense Technology

   • Ruiwen Zhang, Hui Wang

   Pages 35-49

6. Cancer Therapeutic Applications of Ribozymes and RNAi

   • Lisa Scherer, John J. Rossi

   Pages 51-63

7. Fusogeneic Membrane Glycoproteins for Cancer Gene Therapy

   • Andrew Bateman, Vy Phan, Alan Melcher, Emmanouela Linardakis, Kevin Harrington, Richard Vile

   Pages 65-80

8. Suicide Gene Therapy

   • Caroline J. Springer, Ion Niculescu-Duvaz

   Pages 81-107

9. Molecular Chemotherapy Approaches

   • Daniel H. Palmer, David J. Kerr

   Pages 109-128

10. Genetic Immunotherapy Approaches

    • Denise R. Shaw, Albert F. LoBuglio

    Pages 129-141

11. Immunotherapy of Cancer by Dendritic Cell-Targeted Gene Transfer

    • Tanja D. de Gruijl, Herbert M. Pinedo, Rik J. Scheper

    Pages 143-172

12. Dendritic Cells

    • Weiping Zou, Shuang Wei, Tyler J. Curiel

    Pages 173-184

13. Polynucleotide Immunization for Cancer Therapy

    • Theresa V. Strong

    Pages 185-197

14. Development of Oncolytic Replication-Competent Herpes Simplex Virus Vectors

    • Tomoki Todo, Samuel D. Rabkin

    Pages 199-210

15. Development of Oncolytic Adenoviruses

    • John A. Howe, Robert Ralston, Murali Ramachandra

    Pages 211-233

16. Conditionally Replicating Adenoviruses for Cancer Treatment

    • Ramon Alemany

    Pages 235-248

17. Reovirus as an Oncolytic Agent

    • Megan K. Patrick, Kara L. Norman, Patrick W. K. Lee

    Pages 249-260

18. Antiangiogenic Gene Therapy of Cancer

    • Steve Gyorffy, Jack Gauldie, A. Keith Stewart, Xiao-Yan Wen

    Pages 261-271

19. Proapoptotic Strategy in Cancer Gene Therapy

    • David H. Holman, Marc L. Hyer, Ahmed El-Zawahry, Gina M. Keller, James S. Norris

    Pages 273-286

20. Antimetastasis

    • Duen-Hwa Yan, Kung-Ming Rau, Mien-Chie Hung

    Pages 287-298

A complete introduction and guide to the latest developments in cancer gene therapy-from bench to bedside. The authors comprehensively review the anticancer genes and gene delivery methods currently available for cancer gene therapy, including the transfer of genetic material into the cancer cells, stimulation of the immune system to recognize and eliminate cancer cells, and the targeting of the nonmalignant stromal cells that support their growth. They also thoroughly examine the advantages and limitations of the different therapies and detail strategies to overcome obstacles to their clinical implementation. Topics of special interest include vector-targeting techniques, the lessons learned to date from clinical trials of cancer gene therapy, and the regulatory guidelines for future trials. Noninvasive techniques to monitor the extent of gene transfer and disease regression during the course of treatment are also discussed.

• cancer treatment
• clinical trial
• gene therapy
• gene transfer
• imaging
• immune system
• immunotherapy
• metastasis
• prostate cancer
• tumor

"...represents an outstanding work, which should not be missed in all laboratories dealing with cancer gene therapy." - Neoplasma

• Division of Human Gene Therapy, Department of Medicine, University of Alabama at Birmingham, Birmingham

  David T. Curiel, Joanne T. Douglas

• Division of Human Gene Therapy, Department of Pathology, University of Alabama at Birmingham, Birmingham

  David T. Curiel, Joanne T. Douglas

• Division of Human Gene Therapy, Department of Surgery, University of Alabama at Birmingham, Birmingham

  David T. Curiel, Joanne T. Douglas

• Division of Human Gene Therapy, Department of Gene Therapy Center, University of Alabama at Birmingham, Birmingham

  David T. Curiel, Joanne T. Douglas

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