Overview
- Editors:
-
-
Jonathan M. Gibbins
-
School of Animal and Microbial Sciences, The University of Reading, Reading, UK
-
Martyn P. Mahaut-Smith
-
Department of Physiology, University of Cambridge, Cambridge, UK
Access this book
Other ways to access
Table of contents (27 protocols)
-
-
Platelet Functional Assays
-
-
- Jane A. May, Stanley Heptinstall
Pages 3-11
-
- Jean-Pierre Cazenave, Philippe Ohlmann, Dominique Cassel, Anita Eckly, Béatrice Hechler, Christian Gachet
Pages 13-28
-
- Paul Harrison, Carol Briggs, Samuel J. Machin
Pages 29-46
-
-
-
-
-
- David Crosby, Alastair W. Poole
Pages 95-96
-
- Joachim Jankowski, Lars Henning, Hartmut Schlüter
Pages 97-108
-
- Tara W. Rutledge, Sidney W. Whiteheart
Pages 109-120
-
- Richard W. Farndale, Philip G. Hargreaves, Joanna L. Dietrich, Rosemary J. Keogh
Pages 121-133
-
- Johan W. M. Heemskerk, Paul Comfurius, Marion A. H. Feijge, Edouard M. Bevers
Pages 135-144
-
-
- Renata Polanowska-Grabowska, Adrian R. L. Gear
Pages 153-163
-
- Suhasini Kulkarni, Warwick S. Nesbitt, Sacha M. Dopheide, Sascha C. Hughan, Ian S. Harper, Shaun P. Jackson
Pages 165-186
-
- Shahrokh Falati, Peter L. Gross, Glenn Merrill-Skoloff, Derek Sim, Robert Flaumenhaft, Alessandro Celi et al.
Pages 187-197
-
-
About this book
12 The average human body has in the order of 10 circulating platelets. They are crucial for hemostasis, and yet excessive platelet activation is a major cause of m- bidity and mortality in western societies. It is therefore not surprising that platelets have become one of the most extensively investigated biological cell types. We are, however, far from understanding precisely how platelets become activated under physiological and pathophysiological conditions. In addition, there are large gaps in our knowledge of platelet production from their giant precursor cell, the megakar- cyte. Understanding megakaryocyte biology will be crucial for the development of platelet gene targeting. The aim of Platelets and Megakaryocytes is therefore to bring together established and recently developed techniques to provide a comprehensive guide to the study of both the platelet and the megakaryocyte. It consists of five s- tions split between two volumes. The more functional assays appear in Volume 1, whereas Volume 2 includes signaling techniques, postgenomic methods, and a n- ber of key perspectives chapters. Part I of Volume 1, Platelets and Megakaryocytes: Functional Assays, describes many well established approaches to the study of platelet function, including aggregometry, secretion, arachidonic acid metabolism, procoagulant responses, pla- let adhesion under static or flow conditions, flow cytometry, and production of microparticles. Although one would ideally wish to perform experiments with human platelets, studies within the circulation using intravital microscopy require the use of animal models, which are described in Chapter 16, vol. 1.
Reviews
"...thorough and detailed...contains useful information regarding the study of platelets and megakaryocytes." - Veterinary Pathology
Editors and Affiliations
-
School of Animal and Microbial Sciences, The University of Reading, Reading, UK
Jonathan M. Gibbins
-
Department of Physiology, University of Cambridge, Cambridge, UK
Martyn P. Mahaut-Smith
