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Cardiac Drug Development Guide

  • Book
  • © 2003

Overview

Editors:
  1. Michael K. Pugsley

    1. Department of Pharmacology, Forest Research Institute, Jersey City

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    You can also search for this editor in PubMed   Google Scholar

Part of the book series: Methods in Pharmacology and Toxicology (MIPT)

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Table of contents (20 protocols)

  1. Front Matter

    Pages i-x
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  2. Introduction

    1. Front Matter

      Pages 1-1
      Download chapter PDF

    2. Cardiac Drug Development

      • Michael K. Pugsley
      Pages 3-24

  3. Novel Molecular Targets for Cardiac Drug Development

    1. Front Matter

      Pages 25-25
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    2. The Role of Cardiac Pacemaker Currents in Antiarrhythmic Drug Discovery

      • David A. Saint
      Pages 27-46

    3. Oxygen Free Radicals in Heart Disease

      • Elizabeth Roth, Laszlo Hejjel
      Pages 47-66

    4. Mitogen-Activated Protein Kinases-Mediated Signaling in Cardiac Pathology

      • Tanya Ravingerova, Miroslav Barancik, Monika Strniskova
      Pages 67-86

    5. Development of Anti-Inflammatory Drugs for Cardiovascular Disease

      • Melanie B. Smith, David J. Lefer
      Pages 87-105

    6. Development and Use of Platelet Glycoprotein Antagonists in Heart Disease

      • Joel S. Bennett
      Pages 107-122

    7. The Sodium-Hydrogen Exchange System in the Heart

      • Morris Karmazyn
      Pages 123-139

    8. Nitric Oxide and Cardiac Ischemia

      • Mariarosaria Bucci, Inmaculada Posadas Mayo, Giuseppe Cirino
      Pages 141-160

  4. Functional Endpoints Evaluating Cardiac Drug Activity

    1. Front Matter

      Pages 161-161
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    2. Ionic Mechanisms of Atrial Fibrillation

      • J. Christian Hesketh, David Fedida
      Pages 163-174

    3. Targeting Ischemic Ventricular Arrhythmias

      • Michael J. A. Walker, Leon J. Guppy
      Pages 175-201

    4. Biochemical Mediators of Ventricular Arrhythmias in Ischemic Heart Disease

      • Hugh Clements-Jewery, Michael J. Curtis
      Pages 203-225

    5. Heterologous Expression Systems and Screening Technologies in Ion Channel Drug Discovery

      • Maurizio Taglialatela
      Pages 227-244

    6. Molecular Diversity of Ion Channels in the Mouse Heart

      • Jeanne M. Nerbonne
      Pages 245-269

    7. Delayed Protection of the Myocardium

      • László Szekeres, James Parratt
      Pages 271-293

  5. Clinical Aspects in Cardiac Drug Development

    1. Front Matter

      Pages 295-295
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    2. Cardiac Troponin Testing for Detection of Myocardial Infarction

      • Fred S. Apple
      Pages 297-316
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About this book

Cardiac Drug Development Guide outlines, in detail, the therapeutics of cardiac medicine currently at the cutting edge of scientific research and development around the world. This volume integrates basic and clinical cardiac pharmacology by c- bining, for the first time, both classical and molecular aspects of therapeutic drug development. The chapters comprise a broad spectrum of therapeutic areas and hence involve a comprehensive discussion of molecular, biochemical, and electrophy- ological concepts based on years of in vitro as well as in vivo pharmacological st- ies. In addition, the latter part of the book includes comprehensive clinical cardiac chapters that describe important topics in molecular medicine. These chapters also discuss current clinical therapeutic trends in medicine and provide an evaluation of the efficacy of novel drugs in these areas. Cardiac Drug Development Guide has many distinctive and outstanding features that set it apart from other cardiac pharmacology books. This book introduces topics in an easily understandable format for researchers in many varying disciplines by integrating and thereby simplifying concepts not usually discussed across a broad range of cardiac disciplines and in a highly technical field. Each chapter not only introduces and describes the physiology, pharmacology, and pathophysiology of the disease, but also overviews the clinical implications of drug development, what stages these areas are currently in, and also reviews some of the methodologies involved in drug discovery and development. As a result, this book provides a comprehensive overview of the most advanced procedures in cardiac pharmacology today.

Reviews

"This book provides a comprehensive overview of many advanced procedures in cardiac pharmacology that should be useful for graduate students and academic scientists as well as researchers in the pharmaceutical and biotechnology drug industries. This is an excellent book for researchers with an interest in cardiac pharmacology. Chapters address a broad spectrum of therapeutic areas and discuss appropriate molecular, biochemical, and electrophysiological in vitro as well as in vivo approaches used in the investigation of cardiovascular pharmacology. Moreover, the book addresses current clinical therapeutic trends in cardiovascular medicine."-Doody's Health Sciences Book Review Journal

"The scope of material covered is comprehensive, providing eclectic coverage of some very topical issues in cardiac biology and cardiac medicine...most of the chapters will be of interest to a much wider audience than pharmacologists...a worthwhile purchase." - Journal of Pharmacological and Toxicological Methods

"This textbook is a comprehensive look into the latest in cardiovascular drug developments and novel therapeutic agents. It covers a broad spectrum of therapeutic areas including ionic channels, adenoviral vector delivery for cardiovascular gene therapy, pharmacometrics, and gender differences in heart failure and angiogenesis therapy in coronary heart disease. It would be useful for clinical researchers and pharmacologists in cardiac drug development. Research scientists, graduate students and pharmacologists involved in both the pharmaceutical and biotechnological drug industries would benefit from this book." - E-STREAMS

Editors and Affiliations

  • Department of Pharmacology, Forest Research Institute, Jersey City

    Michael K. Pugsley

Bibliographic Information

  • Book Title: Cardiac Drug Development Guide

  • Editors: Michael K. Pugsley

  • Series Title: Methods in Pharmacology and Toxicology

  • DOI: https://doi.org/10.1385/1592594042

  • Publisher: Humana Totowa, NJ

  • eBook Packages: Springer Protocols

  • Copyright Information: Springer Science+Business Media New York 2003

  • Hardcover ISBN: 978-1-58829-097-7Published: 30 July 2003

  • Softcover ISBN: 978-1-4899-3828-2Published: 14 August 2013

  • eBook ISBN: 978-1-59259-404-7Published: 06 February 2008

  • Series ISSN: 1557-2153

  • Series E-ISSN: 1940-6053

  • Edition Number: 1

  • Number of Pages: X, 431

  • Topics: Pharmacy

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