Overview
- Editors:
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Francis Ali-Osman
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Department of Surgery, Duke University Medical Center, Durham
Comprehensive Cancer Center, Duke University Medical Center, Durham
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Table of contents (19 chapters)
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Epidemiology, Biology, Genetics, and Pathology
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- Randa El-Zein, Melissa Bondy, Margaret Wrensch
Pages 3-18
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- Catherine L. Nutt, Anat O. Stemmer-Rachamimov, J. Gregory Cairncross, David N. Louis
Pages 33-53
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- Martin Begemann, Vinagolu K. Rajasekhar, Gregory N. Fuller, Eric C. Holland
Pages 55-89
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- Minsoo Kang, Takamitsu Fujimaki, Seiji Yano, Isaiah J. Fidler
Pages 91-106
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- Mark Noble, Joerg Dietrich
Pages 107-123
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- John R. Hill, Shoichiro Ohta, Mark A. Israel
Pages 125-154
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Mechanisms and Pathways
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Front Matter
Pages 155-155
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- Helga E. de Vries, Lisette Montagne, Christine D. Dijkstra, Paul van der Valk
Pages 157-174
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- Hiroko Ohgaki, Paul Kleihues
Pages 207-221
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- Henry S. Friedman, M. Eileen Dolan, Francis Ali-Osman
Pages 223-235
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- Sanjeeva Mohanam, Jasti S. Rao
Pages 237-247
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- Juan Fueyo, Candelaria Gomez-Manzano, Timothy J. McDonnell
Pages 249-264
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Therapeutics
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Front Matter
Pages 265-265
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- Charles A. Conrad, W. K. Alfred Yung
Pages 267-277
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- Nalin Gupta, John R. Fike, Penny K. Sneed, Philip J. Tofilon, Dennis F. Deen
Pages 279-305
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- Fadi Hanbali, Raymond Sawaya
Pages 307-322
About this book
Exciting new developments and discoveries of the last two decades are beginning to shed light on the complex biology of brain tumors and are advancing our understa- ing of the cellular and molecular processes involved in their initiation, progression, and clinical and biological behavior. The disease process in brain tumors is quite complex and the resulting tumors are characterized by a high degree of biological and clinical diversity. Thus, despite the advances of the last two decades, prognosis for patients with malignant brain tumors remains abysmal. Significant progress in the diagnosis, treatment and, ultimately, prevention of these tumors will require both the timely h- nessing of the advances in basic and clinical brain tumor research, and a continuing concerted effort at increasing our understanding of brain tumor biology, in particular, the molecular genetic changes and perturbations of cellular pathways involved in brain oncogenesis and which drive the biological and clinical behavior of the tumors. Brain tumor diagnosis and prognosis, which is still largely based on histopathology and other clinical criteria, will, in the future, acquire a significant molecular component, with the incorporation of knowledge of genes that are mutated, over-expressed, deleted, silenced, or functionally altered in the tumors. Treatment strategies for brain tumors, rather than being empirical, will be rationally developed based on an understanding of the cellular and molecular mechanisms and targets that have been activated, suppressed, or otherwise altered.
Reviews
"This is an important book for the shelves of neuroscience, neurology, neurosurgery, and oncology departments. It's well worth the price." - Doody's Health Sciences Book Review Journal
"This book contains a welcome compilation of the known genetic reference with a good description of each abnormality." - The New England Journal of Medicine
"...this book is simply indispensable and should be a significant component for all individuals associated with either biology or treatment of gliomas...a thoroughly comprehensive, up-to-date, and timely review... ." - J. Neurosurg
Editors and Affiliations
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Department of Surgery, Duke University Medical Center, Durham
Francis Ali-Osman
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Comprehensive Cancer Center, Duke University Medical Center, Durham
Francis Ali-Osman
