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G-Quadruplex Nucleic Acids

Methods and Protocols

  • Includes cutting-edge methods and protocols
  • Provides step-by-step detail essential for reproducible results
  • Contains key notes and implementation advice from the experts

Part of the book series: Methods in Molecular Biology (MIMB, volume 2035)

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Table of contents (26 protocols)

  1. Front Matter

    Pages i-xiv
  2. G-Quadruplex DNA and RNA

    • Danzhou Yang
    Pages 1-24
  3. CD Study of the G-Quadruplex Conformation

    • Iva Kejnovská, Daniel Renčiuk, Jan Palacký, Michaela Vorlíčková
    Pages 25-44
  4. Putting a New Spin of G-Quadruplex Structure and Binding by Analytical Ultracentrifugation

    • William L. Dean, Robert D. Gray, Lynn DeLeeuw, Robert C. Monsen, Jonathan B. Chaires
    Pages 87-103
  5. G-Quadruplex Stability from DSC Measurements

    • San Hadži, Matjaž Bončina, Jurij Lah
    Pages 117-130
  6. X-Ray Crystallographic Studies of G-Quadruplex Structures

    • Gary N. Parkinson, Gavin W. Collie
    Pages 131-155
  7. NMR Studies of G-Quadruplex Structures and G-Quadruplex-Interactive Compounds

    • Clement Lin, Jonathan Dickerhoff, Danzhou Yang
    Pages 157-176
  8. Single-Molecule Investigations of G-Quadruplex

    • Shankar Mandal, Mohammed Enamul Hoque, Hanbin Mao
    Pages 275-298
  9. G-Quadruplex and Protein Binding by Single-Molecule FRET Microscopy

    • Chun-Ying Lee, Christina McNerney, Sua Myong
    Pages 309-322
  10. High-Throughput Screening of G-Quadruplex Ligands by FRET Assay

    • Kaibo Wang, Daniel P. Flaherty, Lan Chen, Danzhou Yang
    Pages 323-331

About this book

This volume covers the structures, properties, and functions of G-quadruplexes in a wide range of biological disciplines, including therapeutic intervention and biomaterial application. The chapters in this book explore a wide range of vital and new experimental techniques used in the study of G-quadruplexes. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.

 
Practical and cutting-edge, G-Quadruplex DNA: Methods and Protocols is a valuable resource for both novice and experienced researchers who work in biophysics, structural biology, computational biology, biochemistry, and molecular and cell biology, and who want to learn more about the potential roles and effects of G-quadruplex in these fields. 



Editors and Affiliations

  • Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University, Purdue Center for Cancer Research, Purdue Institute for Drug Discovery, West Lafayette, USA

    Danzhou Yang

  • Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University, West Lafayette, USA

    Clement Lin

Bibliographic Information

  • Book Title: G-Quadruplex Nucleic Acids

  • Book Subtitle: Methods and Protocols

  • Editors: Danzhou Yang, Clement Lin

  • Series Title: Methods in Molecular Biology

  • DOI: https://doi.org/10.1007/978-1-4939-9666-7

  • Publisher: Humana New York, NY

  • eBook Packages: Springer Protocols

  • Copyright Information: Springer Science+Business Media, LLC, part of Springer Nature 2019

  • Hardcover ISBN: 978-1-4939-9665-0Published: 24 August 2019

  • Softcover ISBN: 978-1-4939-9668-1Published: 25 August 2020

  • eBook ISBN: 978-1-4939-9666-7Published: 23 August 2019

  • Series ISSN: 1064-3745

  • Series E-ISSN: 1940-6029

  • Edition Number: 1

  • Number of Pages: XIV, 437

  • Number of Illustrations: 26 b/w illustrations, 95 illustrations in colour

  • Topics: Human Genetics, Mass Spectrometry

Buy it now

Buying options

eBook USD 109.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 139.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book USD 199.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access