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  • © 2019

Rat Genomics

  • Includes cutting-edge techniques and vital background information
  • Provides detail essential for reproducible results in the lab
  • Contains key implementation advice from the experts

Part of the book series: Methods in Molecular Biology (MIMB, volume 2018)

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Table of contents (16 protocols)

  1. Front Matter

    Pages i-xv
  2. The Rat: A Model Used in Biomedical Research

    • Jennifer R. Smith, Elizabeth R. Bolton, Melinda R. Dwinell
    Pages 1-41
  3. Rat Genome Assemblies, Annotation, and Variant Repository

    • Monika Tutaj, Jennifer R. Smith, Elizabeth R. Bolton
    Pages 43-70
  4. Rat Genome Databases, Repositories, and Tools

    • Stanley J. F. Laulederkind, G. Thomas Hayman, Shur-Jen Wang, Matthew J. Hoffman, Jennifer R. Smith, Elizabeth R. Bolton et al.
    Pages 71-96
  5. Next Generation Transgenic Rat Model Production

    • Wanda E. Filipiak, Elizabeth D. Hughes, Galina B. Gavrilina, Anna K. LaForest, Thomas L. Saunders
    Pages 97-114
  6. Embryonic Stem Cells and Gene Manipulation in Rat

    • Masumi Hirabayashi, Akiko Takizawa, Shinichi Hochi
    Pages 115-130
  7. Protocols for Cryopreservation and Rederivation of Rat Gametes

    • Akiko Takizawa, Tomoo Eto
    Pages 131-149
  8. Fluorescent Imaging and Microscopy for Dynamic Processes in Rats

    • Ruben M. Sandoval, Bruce A. Molitoris, Oleg Palygin
    Pages 151-175
  9. Characterization of the Rat Gut Microbiota via 16S rRNA Amplicon Library Sequencing

    • Aaron C. Ericsson, Susheel B. Busi, James M. Amos-Landgraf
    Pages 195-212
  10. Networking in Biology: The Hybrid Rat Diversity Panel

    • Boris Tabakoff, Harry Smith, Lauren A. Vanderlinden, Paula L. Hoffman, Laura M. Saba
    Pages 213-231
  11. Using Heterogeneous Stocks for Fine-Mapping Genetically Complex Traits

    • Leah C. Solberg Woods, Abraham A. Palmer
    Pages 233-247
  12. Mapping Mammary Tumor Traits in the Rat

    • Michael J. Flister, Amit Joshi, Carmen Bergom, Hallgeir Rui
    Pages 249-267
  13. Rat Models of Metabolic Syndrome

    • Anne E. Kwitek
    Pages 269-285
  14. Genomic Research in Rat Models of Kidney Disease

    • Yoram Yagil, Ronen Levi-Varadi, Chana Yagil
    Pages 287-307
  15. Rat Models of Exercise for the Study of Complex Disease

    • Lauren Gerard Koch, Steven L. Britton
    Pages 309-317
  16. Behavioral Genetic Studies in Rats

    • Yangsu Ren, Abraham A. Palmer
    Pages 319-326
  17. Back Matter

    Pages 327-331

About this book

This book provides both historical perspective and practical information to support researchers either currently involved in genomic research on rats or planning to begin such a project.  In numerous chapters, a detailed protocol is provided for researchers looking to move into a new area of investigation or to leverage a new technology.  In other cases, a detailed review of existing models or a description of available resources can help the researcher find, understand, and utilize the information, the data, and the tools that they need to support their research efforts. Written as part of the highly successful Methods in Molecular Biology series, this collection includes the kind of hands-on detail necessary for success in the lab. 

Authoritative and up-to-date, Rat Genomics explores the rat as a biomedical model uniquely poised to provide the ideal combination of established experimental models, extensive physiological data, and genomic manipulability to facilitate exploration of the underlying biology.

Editors and Affiliations

  • Department of Biomedical Engineering, Rat Genome Database, Medical College of Wisconsin, Milwaukee, USA

    G. Thomas Hayman, Jennifer R. Smith, Mary Shimoyama

  • Department of Physiology, Rat Genome Database, Genomic Sciences and Precision Medicine Center, Medical College of Wisconsin, Milwaukee, USA

    Melinda R. Dwinell

Bibliographic Information

  • Book Title: Rat Genomics

  • Editors: G. Thomas Hayman, Jennifer R. Smith, Melinda R. Dwinell, Mary Shimoyama

  • Series Title: Methods in Molecular Biology

  • DOI: https://doi.org/10.1007/978-1-4939-9581-3

  • Publisher: Humana New York, NY

  • eBook Packages: Springer Protocols

  • Copyright Information: Springer Science+Business Media, LLC, part of Springer Nature 2019

  • Hardcover ISBN: 978-1-4939-9580-6Published: 29 June 2019

  • Softcover ISBN: 978-1-4939-9583-7Published: 14 August 2020

  • eBook ISBN: 978-1-4939-9581-3Published: 21 June 2019

  • Series ISSN: 1064-3745

  • Series E-ISSN: 1940-6029

  • Edition Number: 1

  • Number of Pages: XV, 331

  • Number of Illustrations: 10 b/w illustrations, 54 illustrations in colour

  • Topics: Animal Genetics and Genomics, Animal Models

Buy it now

Buying options

eBook USD 109.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 139.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book USD 199.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access