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Targeted Drug Delivery

Methods and Protocols

  • Book
  • © 2018

Overview

Editors:
  1. Rachael W. Sirianni

    1. Vivian L. Smith Department of Neurosurgery, University of Texas Health Science, Center at Houston, Houston, USA

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    You can also search for this editor in PubMed   Google Scholar

  2. Bahareh Behkam

    1. Department of Mechanical Engineering, Virginia Tech, Blacksburg, USA

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    You can also search for this editor in PubMed   Google Scholar

  • Includes cutting-edge methods and protocols
  • Provides step-by-step detail essential for reproducible results
  • Contains key notes and implementation advice from the experts

Part of the book series: Methods in Molecular Biology (MIMB, volume 1831)

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Table of contents (15 protocols)

  1. Front Matter

    Pages i-xi
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  2. Drug Carrier Design

    1. Front Matter

      Pages 1-1
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    2. Synthesis of Cationic Polymer Libraries for Gene Delivery Using Diglycidyl Ethers

      • Jacob Elmer, Thrimoorthy Potta, Kaushal Rege
      Pages 3-16

    3. Generation of Ultra-Small PLGA Nanoparticles by Sequential Centrifugation

      • Xingwang Wu, Jiangbing Zhou, Toral R. Patel
      Pages 17-24

    4. Construction of Bacteria-Based Cargo Carriers for Targeted Cancer Therapy

      • Mahama A. Traore, Ali Sahari, Bahareh Behkam
      Pages 25-35

    5. Production of Extracellular Vesicles Loaded with Therapeutic Cargo

      • Tek N. Lamichhane, Steven M. Jay
      Pages 37-47

    6. Delivery of Cytotoxic Mesenchymal Stem Cells with Biodegradable Scaffolds for Treatment of Postoperative Brain Cancer

      • Kevin T. Sheets, Juli R. Bagó, Shawn D. Hingtgen
      Pages 49-58

    7. Nanoparticles for Targeted Drug Delivery to Cancer Stem Cells and Tumor

      • Hai Wang, Xiaoming He
      Pages 59-67

  3. Passive and Active Targeting Methods

    1. Front Matter

      Pages 69-69
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    2. Exploiting Phage Display for Development of Novel Cellular Targeting Strategies

      • William Marsh, Amanda Witten, Sarah E. Stabenfeldt
      Pages 71-94

    3. CD44 Targeted Lipid Nanoparticles for MicroRNA Therapy

      • Stephen L. Hayward, Srivatsan Kidambi
      Pages 95-109

    4. Ultrasound and Microbubble-Mediated Blood-Brain Barrier Disruption for Targeted Delivery of Therapeutics to the Brain

      • Meaghan A. O’Reilly, Kullervo Hynynen
      Pages 111-119

    5. In Vitro Validation of Targeting and Comparison to Mathematical Modeling

      • Jill M. Steinbach-Rankins, Michael R. Caplan
      Pages 121-141

  4. Measuring Delivery and Efficacy

    1. Front Matter

      Pages 143-143
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    2. Enzyme-Linked Immunosorbent Assay to Quantify Targeting Molecules on Nanoparticles

      • Rachel S. Riley, Jilian R. Melamed, Emily S. Day
      Pages 145-157

    3. Tunable Collagen Microfluidic Platform to Study Nanoparticle Transport in the Tumor Microenvironment

      • Matthew R. DeWitt, M. Nichole Rylander
      Pages 159-178

    4. Utilizing the Lung as a Model to Study Nanoparticle-Based Drug Delivery Systems

      • Dylan K. McDaniel, Veronica M. Ringel-Scaia, Sheryl L. Coutermarsh-Ott, Irving C. Allen
      Pages 179-190

    5. Non-Enzymatic Tissue Homogenization for Biodistribution Analysis

      • Danielle M. DiPerna, Alesia V. Prakapenka, Eugene P. Chung, Rachael W. Sirianni
      Pages 191-199

    6. Methods and Study Designs for Characterizing the Pharmacokinetics and Pharmacodynamics of Carrier-Mediated Agents

      • Allison N. Schorzman, Andrew T. Lucas, John R. Kagel, William C. Zamboni
      Pages 201-228

  5. Back Matter

    Pages 229-230
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Keywords

About this book

This volume looks at the latest techniques used to enable therapeutic molecules to be targeted for site-specific delivery. The chapters in this book discuss topics such as approaches to express biologically derived and synthetic nanocarriers; strategies to assist in nanocarrier targeting to specific cells and tissues; and methods for evaluating delivery and efficiency for new classes of agents. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.



Cutting-edge and comprehensive, Targeted Drug Delivery: Methods and Protocols is a valuable resource for anyone interested in understanding the diversity of methods used in this evolving field.


Editors and Affiliations

  • Vivian L. Smith Department of Neurosurgery, University of Texas Health Science, Center at Houston, Houston, USA

    Rachael W. Sirianni

  • Department of Mechanical Engineering, Virginia Tech, Blacksburg, USA

    Bahareh Behkam

Bibliographic Information

  • Book Title: Targeted Drug Delivery

  • Book Subtitle: Methods and Protocols

  • Editors: Rachael W. Sirianni, Bahareh Behkam

  • Series Title: Methods in Molecular Biology

  • DOI: https://doi.org/10.1007/978-1-4939-8661-3

  • Publisher: Humana New York, NY

  • eBook Packages: Springer Protocols

  • Copyright Information: Springer Science+Business Media, LLC, part of Springer Nature 2018

  • Hardcover ISBN: 978-1-4939-8659-0Published: 27 July 2018

  • Softcover ISBN: 978-1-4939-9357-4Published: 10 December 2019

  • eBook ISBN: 978-1-4939-8661-3Published: 26 July 2018

  • Series ISSN: 1064-3745

  • Series E-ISSN: 1940-6029

  • Edition Number: 1

  • Number of Pages: XI, 230

  • Number of Illustrations: 13 b/w illustrations, 39 illustrations in colour

  • Topics: Pharmacology/Toxicology

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