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Huntington’s Disease

  • Book
  • © 2018

Overview

Editors:
  1. Sophie V. Precious

    1. Brain Repair Group, Cardiff University, Cardiff, United Kingdom

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    You can also search for this editor in PubMed   Google Scholar

  2. Anne E. Rosser

    1. Brain Repair Group, Cardiff University, Cardiff, United Kingdom

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

  3. Stephen B. Dunnett

    1. Brain Repair Group, Cardiff University, Cardiff, United Kingdom

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

  • Includes cutting-edge techniques for the study of Huntington's Disease
  • Provides clear details essential for reproducible results
  • Contains practical insights from experts in the field

Part of the book series: Methods in Molecular Biology (MIMB, volume 1780)

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Table of contents (29 protocols)

  1. Front Matter

    Pages i-xv
    Download chapter PDF

  2. Stereological Methods to Quantify Cell Loss in the Huntington’s Disease Human Brain

    • Nasim F. Mehrabi, Malvindar K. Singh-Bains, Henry J. Waldvogel, Richard L. M. Faull
    Pages 1-16

  3. Assessing Autophagic Activity and Aggregate Formation of Mutant Huntingtin in Mammalian Cells

    • Eleanna Stamatakou, Ye Zhu, David C. Rubinsztein
    Pages 17-29

  4. A Filter Retardation Assay Facilitates the Detection and Quantification of Heat-Stable, Amyloidogenic Mutant Huntingtin Aggregates in Complex Biosamples

    • Anne Ast, Franziska Schindler, Alexander Buntru, Sigrid Schnoegl, Erich E. Wanker
    Pages 31-40

  5. Cellular Models: HD Patient-Derived Pluripotent Stem Cells

    • Charlene Geater, Sarah Hernandez, Leslie Thompson, Virginia B. Mattis
    Pages 41-73

  6. Nonmammalian Models of Huntington’s Disease

    • Anjalika Chongtham, Brett Barbaro, Tomas Filip, Adeela Syed, Weijian Huang, Marianne R. Smith et al.
    Pages 75-96

  7. Mouse Models of Huntington’s Disease

    • Pamela P. Farshim, Gillian P. Bates
    Pages 97-120

  8. Motor Assessment in Huntington’s Disease Mice

    • Stephen B. Dunnett, Simon P. Brooks
    Pages 121-141

  9. Automated Operant Assessments of Huntington’s Disease Mouse Models

    • Emma Yhnell, Andreas Heuer
    Pages 143-162

  10. Neurophysiological Assessment of Huntington’s Disease Model Mice

    • Elissa J. Donzis, Sandra M. Holley, Carlos Cepeda, Michael S. Levine
    Pages 163-177

  11. Murine Models of Huntington’s Disease for Evaluating Therapeutics

    • Natalia Kosior, Blair R. Leavitt
    Pages 179-207

  12. Generating Excitotoxic Lesion Models of Huntington’s Disease

    • Mariah J. Lelos, Stephen B. Dunnett
    Pages 209-220

  13. Large-Brained Animal Models of Huntington’s Disease: Sheep

    • A. J. Morton
    Pages 221-239

  14. Minipigs as a Large-Brained Animal Model for Huntington’s Disease: From Behavior and Imaging to Gene Therapy

    • Ralf Reilmann, Verena Schuldenzucker
    Pages 241-266

  15. Nonhuman Primate Models of Huntington’s Disease and Their Application in Translational Research

    • Romina Aron Badin
    Pages 267-284

  16. In Vivo Multidimensional Brain Imaging in Huntington’s Disease Animal Models

    • Julien Flament, Philippe Hantraye, Julien Valette
    Pages 285-301

  17. Magnetic Resonance Imaging in Huntington’s Disease

    • Sarah Gregory, Rachael I. Scahill, Geraint Rees, Sarah Tabrizi
    Pages 303-328

  18. Biofluid Biomarkers in Huntington’s Disease

    • Filipe B. Rodrigues, Lauren M. Byrne, Edward J. Wild
    Pages 329-396

  19. Assessing and Modulating Kynurenine Pathway Dynamics in Huntington’s Disease: Focus on Kynurenine 3-Monooxygenase

    • Korrapati V. Sathyasaikumar, Carlo Breda, Robert Schwarcz, Flaviano Giorgini
    Pages 397-413

  20. Assessing Mitochondrial Function in In Vitro and Ex Vivo Models of Huntington’s Disease

    • I. Luísa Ferreira, Catarina Carmo, Luana Naia, Sandra I. Mota, A. Cristina Rego
    Pages 415-442
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Keywords

About this book

This detailed book provides a laboratory manual and guidebook for the selection, implementation, and interpretation of a wide range of techniques in contemporary use in leading laboratories engaged in Huntington’s disease (HD) research worldwide. Only by understanding the pathology and pathogenic process at the fundamental molecular and cellular level can the research community expect to be able to slow or halt the disease process, repair the damage, and develop novel effective therapies to treat the symptoms of this condition, thus this volume collects the practical knowledge of its authors. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. 

Authoritative and invaluable, Huntington’s Disease aims to help scientists to significantly extend the breadth and quality of research in laboratories dedicated to mastering and controlling this devastating human condition.

Editors and Affiliations

  • Brain Repair Group, Cardiff University, Cardiff, United Kingdom

    Sophie V. Precious, Anne E. Rosser, Stephen B. Dunnett

Bibliographic Information

  • Book Title: Huntington’s Disease

  • Editors: Sophie V. Precious, Anne E. Rosser, Stephen B. Dunnett

  • Series Title: Methods in Molecular Biology

  • DOI: https://doi.org/10.1007/978-1-4939-7825-0

  • Publisher: Humana New York, NY

  • eBook Packages: Springer Protocols

  • Copyright Information: Springer Science+Business Media, LLC, part of Springer Nature 2018

  • Hardcover ISBN: 978-1-4939-7824-3Published: 01 June 2018

  • Softcover ISBN: 978-1-4939-9296-6Published: 25 July 2019

  • eBook ISBN: 978-1-4939-7825-0Published: 31 May 2018

  • Series ISSN: 1064-3745

  • Series E-ISSN: 1940-6029

  • Edition Number: 1

  • Number of Pages: XV, 642

  • Number of Illustrations: 37 b/w illustrations, 74 illustrations in colour

  • Topics: Neurosciences

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