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The Biology of Mammalian Spermatogonia

  • Book
  • © 2017

Overview

Editors:
  1. Jon M. Oatley

    1. Centre for Reproductive Biology, School of Molecular Biosciences, Washington State University, Pullman, USA

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  2. Michael D. Griswold

    1. School of Molecular Biosciences, Washington State University, Pullman, USA

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    You can also search for this editor in PubMed   Google Scholar

  • A selection of key topics provide foundation information in mammalian spermatogonial biology

  • Highlights include spermatogonial stem cells, genome integrity, and therapeutic potentials

  • A key reference for researchers new to the field through to experienced scientists

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Table of contents (14 chapters)

  1. Front Matter

    Pages i-xi
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  3. Postnatal Development of the Spermatogonial Population

    1. Front Matter

      Pages 21-21
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    2. Transition of Prenatal Prospermatogonia to Postnatal Spermatogonia

      • John R. McCarrey
      Pages 23-38

    3. Setting the Stage: The First Round of Spermatogenesis

      • Christopher B. Geyer
      Pages 39-63

  4. Spermatogonial Stem Cells

    1. Front Matter

      Pages 65-65
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    2. Defining the Phenotype and Function of Mammalian Spermatogonial Stem Cells

      • Kazadi N. Mutoji, Brian P. Hermann
      Pages 67-90

    3. Regulation of Spermatogonial Stem Cell Maintenance and Self-Renewal

      • Tessa Lord, Jon M. Oatley
      Pages 91-129

  5. Spermatogonial Differentiation

    1. Front Matter

      Pages 131-131
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    2. Role of Retinoic Acid Signaling in the Differentiation of Spermatogonia

      • My-Thanh Beedle, Cathryn A. Hogarth, Michael D. Griswold
      Pages 133-146

    3. Gonadotropin and Steroid Hormone Control of Spermatogonial Differentiation

      • Rod T. Mitchell, Laura O’Hara, Lee B. Smith
      Pages 147-178

  6. Genome Integrity of Spermatogonia

    1. Front Matter

      Pages 179-179
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    2. Frequency of Human Disease Mutations and Spermatogonial Stem Cell Function

      • Norman Arnheim, Peter Calabrese
      Pages 181-204

    3. The Spermatogonial Stem Cell and the Environment

      • Tegan S. A. Horan, Caroline V. Sartain, Patricia A. Hunt
      Pages 205-223

    4. Testicular Germ Cell Tumors and Teratomas

      • Denise G. Lanza, Jason D. Heaney
      Pages 225-267

  7. Tools to Study Spermatogonial Biology

    1. Front Matter

      Pages 269-269
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    2. Transplantation and Culture of Spermatogonial Stem Cells

      • Hiroshi Kubota, Ralph L. Brinster
      Pages 271-300

    3. In Vitro Differentiation of Spermatogonia

      • Takehiko Ogawa
      Pages 301-312

  8. Therapeutic Potentials and Applications of Spermatogonia

    1. Front Matter

      Pages 313-313
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Keywords

About this book

This book provides a resource of current understandings about various aspects of the biology of spermatogonia in mammals. Considering that covering the entire gamut of all things spermatogonia is a difficult task, specific topics were selected to provide foundational information that will be useful for seasoned researchers in the field of germ cell biology as well as investigators entering the area.


Looking to the future, the editors predict that the foundational information provided in this book -- combined with the advent of new tools and budding interests in use of non-rodent mammalian models -- will produce another major advance in knowledge regarding the biology of spermatogonia over the next decade. In particular, we anticipate that the core molecular machinery driving different spermatogonial states in most, if not all, mammals will be described fully, the extrinsic signals emanating from somatic support cell populations to influence spermatogonial functions will become fully known, and the capacity to derive long-term cultures of SSCs and transplant the population to regenerate spermatogenesis and fertility will become a reality for higher order mammals.

Reviews

“This book provides an excellent framework for understanding the biology of mammalian spermatogonia and spermatogonial stem cells. … A unique feature is the use of informative schematic diagrams accompanied by detailed legends. … This is an excellent resource, particularly for students, because it does a fine job of explaining each topic in detail. The authors are correct in stating that this book will be useful to laboratory investigators, both within and outside of the field.” (Prabhakara P. Reddi, Doody's Book Reviews, February, 2018)

Editors and Affiliations

  • Centre for Reproductive Biology, School of Molecular Biosciences, Washington State University, Pullman, USA

    Jon M. Oatley

  • School of Molecular Biosciences, Washington State University, Pullman, USA

    Michael D. Griswold

About the editors

Jon M. Oatley, PhD, is Associate Professor and Director for the Center for Reproductive Biology, Washington State University.

Michael D. Griswold, PhD, is Regents Professor of Molecular Biosciences, Washington State University.  

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