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Integrin Targeting Systems for Tumor Diagnosis and Therapy

  • Book
  • © 2018

Overview

Editors:
  1. Eleonora Patsenker

    1. Department of Gastroenterology and Hepatology, UniversitätsSpital Zürich, Zürich, Switzerland

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  • Features techniques and methodologies to facilitate integrin biology research and target identification
  • Examines approaches for the treatment of multiple organ diseases, with a focus on cancer
  • Includes practical advice to ensure success in the lab

Part of the book series: Methods in Pharmacology and Toxicology (MIPT)

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Table of contents (13 protocols)

  1. Front Matter

    Pages i-xi
    Download chapter PDF

  2. Tumor Targeting by RGD-Grafted PLGA-Based Nanotheranostics Loaded with Paclitaxel and Superparamagnetic Iron Oxides

    • Fabienne Danhier, Pierre Danhier, Nathalie Schleich, Chrystelle Po, Sophie Laurent, Pierre Sibret et al.
    Pages 1-17

  3. Fabrication of cRGD-Conjugated Dual-Responsive Micelles to Target αvβ5 Integrin-Overexpressed Cancer

    • Huacheng He, Remant Bahadur K.C., Peisheng Xu
    Pages 19-34

  4. Copper-Free Click Chemistry Modification of Nanovectors for Integrin-Targeted Cancer Therapy

    • Chang-Fang Wang, Hélder A. Santos
    Pages 35-49

  5. Preparation, Characterization, and In Vitro and In Vivo Evaluation of PEGylated Liposomal Doxorubicin Modified with Different cRGD Peptides

    • Mohamadreza Amin, Mahmoud Reza Jaafari
    Pages 51-68

  6. Preparation of Heterobivalent and Multivalent Radiopharmaceuticals to Target Tumors Over-Expressing Integrins

    • Guillermina Ferro-Flores, Blanca Ocampo-García, Clara Santos-Cuevas, Nallely Jiménez-Mancilla, Myrna Luna-Gutiérrez, Flor de M. Ramírez et al.
    Pages 69-92

  7. 177Lu-Labeled RGD-BBN Peptide for Targeting Prostate Cancer

    • Lei Jiang, Zhen Cheng
    Pages 93-98

  8. Integrin-Mediated Targeting of Liposomally Bound siRNAs to Tumor Vasculatures

    • Poulami Majumder, Arabinda Chaudhuri
    Pages 99-122

  9. Integrin αvβ3-Targeted Optical Imaging with Metal Oxide Nanomaterials: Focusing on Zinc Oxide

    • Hao Hong, Weibo Cai
    Pages 123-134

  10. Integrin Targeting Using RGD-Based Peptide Amphiphiles

    • Poonam Saraf, Xiaoling Li, Bhaskara Jasti
    Pages 135-155

  11. Cyclic-RGDfK-Directed Docetaxel Loaded Nanomicelles for Angiogenic Tumor Targeting

    • Hitesh Kulhari, Deep Pooja, Shweta Shrivastava, T. Srinivasa Reddy, Ayan Kumar Barui, Chitta Ranjan Patra et al.
    Pages 157-168

  12. Targeting Glioma Cancer Cells with Fluorescent Nanodiamonds via Integrin Receptors

    • Jitka Neburkova, Miroslav Hajek, Ivan Rehor, Jiri Schimer, Frantisek Sedlak, Jan Stursa et al.
    Pages 169-189

  13. NIR Imaging-Guided Photothermal Therapy by cRGD-Conjugated Solid Lipid Nanoparticles Encapsulating IR-780

    • Ye Kuang, Kunchi Zhang, Min Liu, Renjun Pei
    Pages 191-206

  14. Synergistic Active Targeting to B16F10 Tumors by αvβ3/CD44-Targeted Nanoparticles Loaded with Docetaxel

    • Sanjun Shi
    Pages 207-223

  15. Back Matter

    Pages 225-226
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Keywords

About this book

This volume collects a variety of techniques and methodologies developed to facilitate research on integrin biology and to identify ideal targets and approaches for the treatment of multiple organ diseases, with a focus on cancer in particular. The chapters consecutively describe the tools for structural analysis, identification and detection of integrins as biomarkers, and include thorough laboratory and clinically-related methods on different strategies for generation, synthesis and evaluation of probes, carriers, peptides or small particles for integrin targeting, imaging, and drug delivery. As part of the Methods in Pharmacology and Toxicology series, this book contains the practical details that are invaluable in the laboratory. 
Authoritative and advantageous, Integrin Targeting Systems for Tumor Diagnosis and Therapy serves readers from a wide spectrum, including researchers and students seeking an overview of existing developments, as well as leading professionals aiming to become more familiar with integrin-related innovative technologies in cancer research.

Editors and Affiliations

  • Department of Gastroenterology and Hepatology, UniversitätsSpital Zürich, Zürich, Switzerland

    Eleonora Patsenker

Bibliographic Information

  • Book Title: Integrin Targeting Systems for Tumor Diagnosis and Therapy

  • Editors: Eleonora Patsenker

  • Series Title: Methods in Pharmacology and Toxicology

  • DOI: https://doi.org/10.1007/978-1-4939-7445-0

  • Publisher: Humana New York, NY

  • eBook Packages: Springer Protocols

  • Copyright Information: Springer Science+Business Media, LLC, part of Springer Nature 2018

  • Hardcover ISBN: 978-1-4939-7443-6Published: 03 May 2018

  • Softcover ISBN: 978-1-4939-9247-8Published: 10 December 2019

  • eBook ISBN: 978-1-4939-7445-0Published: 03 May 2018

  • Series ISSN: 1557-2153

  • Series E-ISSN: 1940-6053

  • Edition Number: 1

  • Number of Pages: XI, 226

  • Number of Illustrations: 20 b/w illustrations, 24 illustrations in colour

  • Topics: Pharmacology/Toxicology

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