Skip to main content
SpringerLink
Log in
Book cover

Developmental and Reproductive Toxicology

  • Book
  • © 2017

Overview

Editors:
  1. Ali S. Faqi

    1. MPI Research, Mattawan, USA

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

  • Features in vivo assessments that are guideline-driven and required for submissions for product approval
  • Covers a variety of toxicological issues in both male and female reproductive systems
  • Provides vital procedures for the study of phamaceutical safety assessment
  • Includes supplementary material: sn.pub/extras

Part of the book series: Methods in Pharmacology and Toxicology (MIPT)

This is a preview of subscription content, log in via an institution to check access.

Access this book

Log in via an institution
eBook USD 89.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 119.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access

Licence this eBook for your library

Institutional subscriptions

Table of contents (9 protocols)

  1. Front Matter

    Pages i-xii
    Download chapter PDF

  2. Metabolism and Drug–Drug Interaction in Pregnant Mother/Placenta/Fetus

    • Ali S. Faqi, Karsten A. Holm
    Pages 1-16

  3. Critical Periods of Development in Teratology

    • Padmanahban Rengasamy
    Pages 17-42

  4. Nonclinical Safety Assessment of Developmental and Reproductive Toxicology: Considerations for Conducting Fertility, Embryo–Fetal Development, and Prenatal and Postnatal Developmental Toxicology Studies

    • Kevin H. Denny, Ali S. Faqi
    Pages 43-115

  5. A Developmental and Reproductive Toxicology Program for Chemical Registration

    • Kamin J. Johnson, Bethany R. Hannas, Sue Marty, Carol L. Zablotny, Jessica LaRocca, Nicholas Ball et al.
    Pages 117-183

  6. The Influence of Environmental Contaminants and Lifestyle on Testicular Damage and Male Fertility

    • Sellappan Selvaraju, Meritxell Jodar, Stephen A. Krawetz
    Pages 185-203

  7. Effects of Chemicals on Mammary Gland Development

    • Adam J. Filgo, Ali S. Faqi
    Pages 205-234

  8. Alternative Methods Used to Assess Potential Embryo-Fetal Developmental Risk of Pharmaceuticals

    • Maia L. Green, Joshua T. Gamse, Kimberly C. Brannen
    Pages 235-259

  9. Using the Alternative Model C. elegans in Reproductive and Developmental Toxicology Studies

    • Daniel W. Ferreira, Yichang Chen, Patrick Allard
    Pages 261-278

  10. High-Throughput Screens for Embryonic Stem Cells: Stress-Forced Potency-Stemness Loss Enables Toxicological Assays

    • Quanwen Li, Yu Yang, Erica Louden, Elizabeth E. Puscheck, Daniel A. Rappolee
    Pages 279-312

  11. Back Matter

    Pages 313-314
    Download chapter PDF
Back to top

Keywords

About this book

This meticulous volume covers metabolism and drug-drug interactions during pregnancy, critical periods of developmental toxicology, in vivo and alternative methods to assess potential developmental toxicity for drugs and chemicals, and effects of chemicals on testes and mammary glands. Evaluation of developmental and reproductive toxicology endpoints is an integral part of the safety assessment process for compounds with potential use in women of childbearing age or females that might be exposed during pregnancy as well as men of reproductive potential. The in vivo assessments included here are guideline-driven and are required for submissions for product approval. Written for the Methods in Pharmacology and Toxicology series, this collection includes the kind of detailed implementation advice necessary for success in the lab. 

Authoritative and practical, Developmental and Reproductive Toxicology is an ideal resource for researchers working
in this vital field of study.

Editors and Affiliations

  • MPI Research, Mattawan, USA

    Ali S. Faqi

Bibliographic Information

  • Book Title: Developmental and Reproductive Toxicology

  • Editors: Ali S. Faqi

  • Series Title: Methods in Pharmacology and Toxicology

  • DOI: https://doi.org/10.1007/978-1-4939-7208-1

  • Publisher: Humana New York, NY

  • eBook Packages: Springer Protocols

  • Copyright Information: Springer Science+Business Media LLC 2017

  • Hardcover ISBN: 978-1-4939-7206-7Published: 18 August 2017

  • Softcover ISBN: 978-1-4939-8416-9Published: 15 June 2018

  • eBook ISBN: 978-1-4939-7208-1Published: 17 August 2017

  • Series ISSN: 1557-2153

  • Series E-ISSN: 1940-6053

  • Edition Number: 1

  • Number of Pages: XII, 314

  • Number of Illustrations: 7 b/w illustrations, 17 illustrations in colour

  • Topics: Pharmacology/Toxicology

Publish with us

Policies and ethics

Back to top

Search

Navigation