Vaccines for Invasive Fungal Infections

1. Front Matter

   Pages i-xii

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2. Discovery and Testing of Vaccine Candidates

   1. Front Matter

      Pages 1-1

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   2. Mouse Immunization with Radioattenuated Yeast Cells of Paracoccidioides brasiliensis

      • Estefânia Mara do Nascimento Martins, Antero Silva Ribeiro de Andrade

      Pages 3-21

   3. Heat-Killed Yeast as a Pan-Fungal Vaccine

      • Marife Martinez, Karl V. Clemons, David A. Stevens

      Pages 23-30

   4. Immunoinformatics as a Tool for New Antifungal Vaccines

      • Rupanjali Chaudhuri, Srinivasan Ramachandran

      Pages 31-43

   5. Rational Design of T Lymphocyte Epitope-Based Vaccines Against Coccidioides Infection

      • Brady J. Hurtgen, Chiung-Yu Hung

      Pages 45-64

   6. Identification of Fungal T Cell Epitopes by Mass Spectrometry-Based Proteomics

      • Bernd Roschitzki, Salomé LeibundGut-Landmann

      Pages 65-74

   7. Intranasal Antifungal Vaccination Using DNA-Transfected Dendritic Cells

      • Shanjana Awasthi

      Pages 75-83

   8. DNAhsp65 Vaccine as Therapy against Paracoccidioidomycosis

      • Alice M. Ribeiro, André C. Amaral, Maria Sueli S. Felipe, Anamelia L. Bocca

      Pages 85-96

   9. Idiotypic Antifungal Vaccination: Immunoprotection by Antiidiotypic Antibiotic Antibodies

      • Luciano Polonelli, Walter Magliani, Stefania Conti

      Pages 97-112

   10. Peptide Vaccine Against Paracoccidioidomycosis

       • Carlos P. Taborda, Luiz R. Travassos

       Pages 113-128

   11. Methodology for Anti-Cryptococcal Vaccine Development

       • Ashok K. Chaturvedi, Floyd L. Wormley Jr

       Pages 129-140

3. Design and Delivery

   1. Front Matter

      Pages 141-141

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   2. Beta-Glucan Particles as Vaccine Adjuvant Carriers

      • Zeynep Mirza, Ernesto R. Soto, Fusun Dikengil, Stuart M. Levitz, Gary R. Ostroff

      Pages 143-157

   3. Th1-Inducing Agents in Prophylaxis and Therapy for Paracoccidioidomycosis

      • Thiago Aparecido da Silva, Fabrício Freitas Fernandes, Taise Natali Landgraf, Ademílson Panunto-Castelo, Maria Cristina Roque-Barreira

      Pages 159-167

   4. Nanoparticle-Based Mycosis Vaccine

      • Swaleha Zubair, Asim Azhar, Nazoora Khan, Ejaj Ahmad, Mohd Ajmal, Mohammad Owais

      Pages 169-211

   5. Yeast Expressing Gp43 Protein as a Vaccine Against Paracoccidioides brasiliensis Infection

      • Aline Ferreira Oliveira, Paulo S. R. Coelho

      Pages 213-224

   6. Vaccination with Phage-Displayed Antigenic Epitope

      • Yicun Wang, Li Wang

      Pages 225-235

   7. Preparation of an Oral Vaccine by Proteome Analysis and Molecular Display Technology

      • Seiji Shibasaki, Mitsuyoshi Ueda

      Pages 237-245

4. Endpoint Assessment

   1. Front Matter

      Pages 247-247

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This detailed volume focuses on the development of mycosis vaccines via the most common etiological agents of mycoses, such as Aspergillus and Candida species, followed by Cryptococcus, dimorphic fungi, and members of Mucoraceae family of fungi. The book is sectioned into five parts that describe experimental approaches for vaccine candidate discovery, improved vaccine design and delivery, assessment of critical endpoints, analysis of mechanisms of mycosis vaccine protection, and key methods for clinical translation. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting known pitfalls. 

Practical and authoritative, Vaccines for Invasive Fungal Infections: Methods and Protocols provides a standard reference forvaccine researchers, including those who aspire to strengthen their knowledge or desire to acquire a particular technique.

• Immunosuppressive conditions
• Fungal pathogens
• Aspergillus and Candida species
• Mycoses
• Invasive mycosis vaccines
• Endpoint assessment
• Vaccine design and delivery
• Clinical translation

• Department of Molecular Immunology, Beckman Research Institute of City of Hope, Duarte, USA

  Markus Kalkum, Margarita Semis

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