Skip to main content
SpringerLink
Log in
Book cover

Stem Cell-Derived Models in Toxicology

  • Book
  • © 2017

Overview

Editors:
  1. Mike Clements

    1. Axion BioSystems, Inc., Atlanta, USA

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

  2. Liz Roquemore

    1. Cell Applications, GE Healthcare, Cardiff, United Kingdom

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

  • Collects stem cell-derived model-based toxicity assays, both classic and cutting-edge
  • Features contributions from key opinion leaders from academia and industry
  • Examines the accompanying rationale and example output data necessary for practical and easy-to-use resource
  • Includes supplementary material: sn.pub/extras

Part of the book series: Methods in Pharmacology and Toxicology (MIPT)

This is a preview of subscription content, log in via an institution to check access.

Access this book

Log in via an institution
eBook USD 84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 139.00
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book USD 109.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access

Licence this eBook for your library

Institutional subscriptions

Table of contents (16 protocols)

  1. Front Matter

    Pages i-xii
    Download chapter PDF

  2. Stem Cell-Derived Models for Safety and Toxicity Assessments: Present and Future Studies in the “Proclinical Space”

    • Gary Gintant, Stefan Braam
    Pages 1-15

  3. Human Pluripotent Stem Cell Test for Assessing the Potential Teratogen Risk

    • Sei Kameoka, Eric Chiao
    Pages 17-35

  4. Cardiac Action Potential Measurement in Human Embryonic Stem Cell Cardiomyocytes for Cardiac Safety Studies Using Manual Patch-Clamp Electrophysiology

    • Muthukrishnan Renganathan, Haiyang Wei, Yong Zhao
    Pages 37-56

  5. Automated Patch Clamp Recordings of Human Stem Cell-Derived Cardiomyocytes

    • Alison Obergrussberger, Claudia Haarmann, Sonja Stölzle-Feix, Nadine Becker, Atsushi Ohtsuki, Andrea Brüggemann et al.
    Pages 57-82

  6. The CiPA Microelectrode Array Assay with hSC-Derived Cardiomyocytes: Current Protocol, Future Potential

    • Daniel C. Millard, Mike Clements, James D. Ross
    Pages 83-107

  7. Optogenetic Approach to Cardiotoxicity Screening: Simultaneous Voltage and Calcium Imaging Under Paced Conditions

    • Graham T. Dempsey, Christopher A. Werley
    Pages 109-134

  8. HTS-Compatible Voltage- and Ca2+-Sensitive Dye Recordings from hiPSC-Derived Cardiomyocytes Using the Hamamatsu FDSS Systems

    • Ralf Kettenhofen
    Pages 135-152

  9. Kinetic Image Cytometry for Predicting Arrhythmias Using Human Stem Cell-Derived Cardiomyocytes

    • Emily R. Pfeiffer, Ross Whittaker, Raquel Vega, Fabio Cerignoli, Patrick M. McDonough, Jeffrey H. Price
    Pages 153-171

  10. Decoding Ca2+ Signals as a Non-electrophysiological Method for Assessing Drug Toxicity in Stem Cell-Derived Cardiomyocytes

    • Christopher H. George, David H. Edwards
    Pages 173-190

  11. Combined Impedance and Extracellular Field Potential Recordings from Human Stem Cell-Derived Cardiomyocytes

    • Alison Obergrussberger, Ulrich Thomas, Sonja Stölzle-Feix, Nadine Becker, Krisztina Juhasz, Leo Doerr et al.
    Pages 191-209

  12. Edge-Detection for Contractility Measurements with Cardiac Spheroids

    • Christian Zuppinger
    Pages 211-227

  13. Contractile Force Readout of hESC-Cardiomyocytes

    • Carlota Oleaga, Gregg Legters, L. Richard Bridges, Lee Kumanchik, Candace Martin, Yunqing Cai et al.
    Pages 229-246

  14. In Vitro Cardiotoxicity Investigation Using High Content Analysis and Human Stem Cell-Derived Models

    • Liz Roquemore, M. Ariel Kauss, Catherine Hather, Nick Thomas, Hirdesh Uppal
    Pages 247-269

  15. Structural Toxicity: Hypertrophy Models of Human Pluripotent Stem Cell-Derived Cardiomyocytes

    • Janos Kriston-Vizi, Sian E. Harding, Gábor Földes
    Pages 271-291

  16. Addressing Functional Neurotoxicity Using the Microelectrode Array (MEA)

    • Udo Kraushaar, Elke Guenther, Dietmar Hess
    Pages 293-309

  17. Micropatterned Co-Cultures of Induced Pluripotent Stem Cell-Derived Hepatocytes and Stromal Cells for Drug Toxicity Studies

    • Brenton R. Ware, Salman R. Khetani
    Pages 311-334

  18. Back Matter

    Pages 335-341
    Download chapter PDF
Back to top

Keywords

About this book

This detailed volume brings together a diverse collection of stem cell-derived model-based toxicity assays, from those routinely used to those deemed to have considerable potential. With a focus on differentiated tissues, the chapters explore numerous cardiotoxicity applications as well as coverage of neurotoxicity, hepatotoxicity, and more. Written for the Methods in Pharmacology and Toxicology series, the contents of this book aim to enable adoption of these protocols in laboratories that are interested in entering the field as well as to facilitate the transfer of best practices between laboratories that are already actively pursuing these technologies. 

Authoritative and cutting-edge, Stem Cell-Derived Models in Toxicology serves as a vital resource for researchers aiming to improve risk assessment in drug discovery and design.

Editors and Affiliations

  • Axion BioSystems, Inc., Atlanta, USA

    Mike Clements

  • Cell Applications, GE Healthcare, Cardiff, United Kingdom

    Liz Roquemore

Bibliographic Information

  • Book Title: Stem Cell-Derived Models in Toxicology

  • Editors: Mike Clements, Liz Roquemore

  • Series Title: Methods in Pharmacology and Toxicology

  • DOI: https://doi.org/10.1007/978-1-4939-6661-5

  • Publisher: Humana New York, NY

  • eBook Packages: Springer Protocols

  • Copyright Information: Springer Science+Business Media, LLC, part of Springer Nature 2017

  • Hardcover ISBN: 978-1-4939-6659-2Published: 26 November 2016

  • Softcover ISBN: 978-1-4939-8264-6Published: 27 June 2018

  • eBook ISBN: 978-1-4939-6661-5Published: 23 November 2016

  • Series ISSN: 1557-2153

  • Series E-ISSN: 1940-6053

  • Edition Number: 1

  • Number of Pages: XII, 341

  • Number of Illustrations: 16 b/w illustrations, 108 illustrations in colour

  • Topics: Pharmacology/Toxicology

Publish with us

Policies and ethics

Back to top

Search

Navigation