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Injury Models of the Central Nervous System

Methods and Protocols

  • Book
  • © 2016

Overview

Editors:
  1. Firas H. Kobeissy

    1. Banyan Biomarkers, Inc., Alachua, USA

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  2. C. Edward Dixon

    1. Safar Center for Resuscitation Research, University of Pittsburgh Safar Center for Resuscitation Research, Pittsburgh, USA

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  3. Ronald L. Hayes

    1. Banyan Biomarkers, Inc. , Alachua, USA

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  4. Stefania Mondello

    1. Banyan Biomarkers, Inc., Alachua, USA

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  • Includes cutting-edge methods and protocols
  • Provides step-by-step detail essential for reproducible results
  • Contains key notes and implementation advice from experts
  • Includes supplementary material: sn.pub/extras

Part of the book series: Methods in Molecular Biology (MIMB, volume 1462)

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Table of contents (40 protocols)

  1. Front Matter

    Pages i-xxiv
    Download chapter PDF

  2. Introduction

    1. Front Matter

      Pages 1-1
      Download chapter PDF

    2. The History and Evolution of Experimental Traumatic Brain Injury Models

      • John Povlishock
      Pages 3-7

  3. General Consideration in Using Animal Laboratory in CNS Injury Research

    1. Front Matter

      Pages 9-9
      Download chapter PDF

    2. Clinical Traumatic Brain Injury in the Preclinical Setting

      • Justin Berkner, Rebekah Mannix, Jianhua Qiu
      Pages 11-28

    3. Rodent Models of Traumatic Brain Injury: Methods and Challenges

      • Niklas Marklund
      Pages 29-46

    4. Traumatic Brain Injury Models in Animals

      • Elham Rostami
      Pages 47-59

    5. Systematic Review of Traumatic Brain Injury Animal Models

      • Helen W. Phipps
      Pages 61-88

    6. Methods of Drug Delivery in Neurotrauma

      • Ying Deng-Bryant, Ryan Readnower, Lai Yee Leung, Frank Tortella, Deborah Shear
      Pages 89-100

    7. Bridging the Gap of Standardized Animals Models for Blast Neurotrauma: Methodology for Appropriate Experimental Testing

      • Pamela J. VandeVord, Alessandra Dal Cengio Leonardi, David Ritzel
      Pages 101-118

    8. Cellular Mechanisms and Behavioral Outcomes in Blast-Induced Neurotrauma: Comparing Experimental Setups

      • Zachary S. Bailey, W. Brad Hubbard, Pamela J. VandeVord
      Pages 119-138

    9. Application of Systems Biology to Neuroproteomics: The Path to Enhanced Theranostics in Traumatic Brain Injury

      • Zaynab Jaber, Patrick Aouad, Mohamad Al Medawar, Hisham Bahmad, Hussein Abou-Abbass, Firas Kobeissy
      Pages 139-155

    10. Role of Systems Biology in Brain Injury Biomarker Discovery: Neuroproteomics Application

      • Zaynab Jaber, Patrick Aouad, Mohamad Al Medawar, Hisham Bahmad, Hussein Abou-Abbass, Hiba Ghandour et al.
      Pages 157-174

  4. Classical TBI Models and Their Link with Pathophysiological Features of CNS Injury—Models

    1. Front Matter

      Pages 175-175
      Download chapter PDF

    2. The Controlled Cortical Impact Model of Experimental Brain Trauma: Overview, Research Applications, and Protocol

      • Nicole Osier, C. Edward Dixon
      Pages 177-192

    3. Weight Drop Models in Traumatic Brain Injury

      • Brian T. Kalish, Michael J. Whalen
      Pages 193-209

    4. Midline (Central) Fluid Percussion Model of Traumatic Brain Injury

      • Rachel K. Rowe, Daniel R. Griffiths, Jonathan Lifshitz
      Pages 211-230

    5. Lateral (Parasagittal) Fluid Percussion Model of Traumatic Brain Injury

      • Ken C. Van, Bruce G. Lyeth
      Pages 231-251

    6. Impact Acceleration Model of Diffuse Traumatic Brain Injury

      • Sarah C. Hellewell, Jenna M. Ziebell, Jonathan Lifshitz, M. Cristina Morganti-Kossmann
      Pages 253-266

    7. Experimental Models for Neurotrauma Research

      • Johan Davidsson, Mårten Risling
      Pages 267-288
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Keywords

About this book

This volume discusses experimental brain injury models that contain valuable information carefully chosen to widen the researchers’ horizon about neurotrauma. Injury Models of Central Nervous System: Methods and Protocols contains relevant experimental design approaches that have been adapted and made ready for application in laboratory settings. For easier navigation, the chapters are categorized into 6 parts: Introduction, General Consideration in Using Animal Laboratory in CNS Injury Research, Classical TBI Models and Their Link with Pathophysiological Features of CBS Injury – Models, Special Topics in CNS Trauma: Comorbid Conditions in CNS Injury, Outcome Measures in Brain Injury Models, and Future Directions. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.

Practical and thorough, Injury Models of Central Nervous Systems: Methods and Protocols, is a very useful reference towards the progress of this discipline.

 

Editors and Affiliations

  • Banyan Biomarkers, Inc., Alachua, USA

    Firas H. Kobeissy, Stefania Mondello

  • Safar Center for Resuscitation Research, University of Pittsburgh Safar Center for Resuscitation Research, Pittsburgh, USA

    C. Edward Dixon

  • Banyan Biomarkers, Inc. , Alachua, USA

    Ronald L. Hayes

Bibliographic Information

  • Book Title: Injury Models of the Central Nervous System

  • Book Subtitle: Methods and Protocols

  • Editors: Firas H. Kobeissy, C. Edward Dixon, Ronald L. Hayes, Stefania Mondello

  • Series Title: Methods in Molecular Biology

  • DOI: https://doi.org/10.1007/978-1-4939-3816-2

  • Publisher: Humana New York, NY

  • eBook Packages: Springer Protocols

  • Copyright Information: Springer Science+Business Media New York 2016

  • Hardcover ISBN: 978-1-4939-3814-8Published: 08 September 2016

  • Softcover ISBN: 978-1-4939-8147-2Published: 09 June 2018

  • eBook ISBN: 978-1-4939-3816-2Published: 07 September 2016

  • Series ISSN: 1064-3745

  • Series E-ISSN: 1940-6029

  • Edition Number: 1

  • Number of Pages: XXIV, 743

  • Number of Illustrations: 53 b/w illustrations, 104 illustrations in colour

  • Topics: Neurosciences

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