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Animal Models of Behavior Genetics

  • Book
  • © 2016

Overview

Editors:
  1. Jonathan C. Gewirtz

    1. Department of Psychology, University of Minnesota, Minneapolis, USA

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    You can also search for this editor in PubMed   Google Scholar

  2. Yong-Kyu Kim

    1. Janelia Research Campus, Howard Hughes Medical Institue, Ashburn, USA

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

  • Provides source information for behavioral genetics researchers
  • Written by leading researchers expert in animal behavioral models in behavioral genetics research
  • Focuses on both function and dysfunction

Part of the book series: Advances in Behavior Genetics (AIBG)

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Table of contents (12 chapters)

  1. Front Matter

    Pages i-xvi
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  2. Animal Models of Normative Behavior

    1. Front Matter

      Pages 1-1
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    2. Male Fruit Fly’s Courtship and Its Double Control by the Fruitless and Doublesex Genes

      • Daisuke Yamamoto
      Pages 3-33

    3. A Drosophila Model for Aggression

      • Yong-Kyu Kim
      Pages 35-61

    4. The Genetics of Impulsivity: A Synthesis of Findings in Humans and Rodent Models

      • Bianca Jupp, Jeffrey W. Dalley
      Pages 63-100

    5. The Neurobiology and Genetics of Affiliation and Social Bonding in Animal Models

      • Zoe R. Donaldson, Larry J. Young
      Pages 101-134

  3. Animal Models of Cognitive Processes and Cognitive Decline

    1. Front Matter

      Pages 135-135
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    2. Intellectual Disability

      • Pierre L. Roubertoux, Michèle Carlier
      Pages 137-166

    3. Neurodegenerative Diseases and Dementia

      • Christopher Janus, Hans Welzl
      Pages 167-197

    4. Genetic Models of Alzheimer’s Disease: The Influence of Apolipoprotein E allele Isoforms on Behaviour in Laboratory Animals

      • Matthew A. Albrecht, Jonathan K. Foster
      Pages 199-228

  4. Animal Models of Psychopathology

    1. Front Matter

      Pages 229-229
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    2. Social Endophenotypes in Mouse Models of Psychiatric Disease

      • Marc T. Pisansky, Irving I. Gottesman, Jonathan C. Gewirtz
      Pages 231-264

    3. Rodent Models of Autism, Epigenetics, and the Inescapable Problem of Animal Constraint

      • Garet P. Lahvis
      Pages 265-301

    4. Animal Models of Addiction: Genetic Influences

      • Nathan A. Holtz, Marilyn E. Carroll
      Pages 303-331

    5. Potentiation of the Startle Reflex as a Behavioral Measure of Anxiety

      • Jonathan C. Gewirtz, Anna K. Radke
      Pages 333-357

  5. Future Directions for Animal Models in Behavior Genetics

    1. Front Matter

      Pages 359-359
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    2. Future Directions for Animal Models in Behavior Genetics

      • Patrick E. Rothwell, Marc V. Fuccillo
      Pages 361-381

  6. Back Matter

    Pages 383-389
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Keywords

About this book

This stimulating analysis reviews the broad potential of animal models to foster a deeper understanding of human pathology, strengthen connections between genetic and behavioral studies, and develop more effective treatments for mental disorders. Widely-studied and lesser-used species are examined in models that capture features along the continuum of normative and pathological behavior. The models highlight genetic causes of core features, or endophenotypes, of developmental, internalizing, and externalizing disorders, as well as dementia. Expert contributors address questions ranging from how suitable species are chosen for study to the costs and benefits of using inbred versus outbred strains, and the effects of housing environment on subject animals. Larger issues addressed include how to evaluate the applicability of animal behavioral models to the human condition and how these models can harness emerging molecular technologies to further our understanding of the genetic basis ofmental illness.

Included in the coverage:

  • Mating and fighting in Drosophila.
  • Attachment and social bonding.
  • Impulsivity in rodents and humans.
  • Animal models of cognitive decline.
  • Animal models of social cognition.
  • Future directions for animal models in behavioral genetics.

A detailed map of where this evolving field is headed, Animal Models of Behavior Genetics shows geneticists, molecular biologists, and cognitive neuroscientists paths beyond established concepts toward a more knowledgeable and collaborative future.

Reviews

“Animal Models of Behavior Genetics is a nice addition to the bookshelf. Students across many disciplines will find it to be a useful starting point for research into the animal models of various behavior systems.” (R. Nicolle Carr, PsycCRITIQUES, Vol. 62 (11), March, 2017)

Editors and Affiliations

  • Department of Psychology, University of Minnesota, Minneapolis, USA

    Jonathan C. Gewirtz

  • Janelia Research Campus, Howard Hughes Medical Institue, Ashburn, USA

    Yong-Kyu Kim

About the editors

Jonathan Gewirtz is Associate Professor in the Departments of Psychology and Neuroscience at the University of Minnesota, and Associate Chair of the Department of Psychology. His research uses rodent models to study the biology of negative affective states, including fear, anxiety and drug dependence. He also studies the cognitive and emotional consequences of developmental disorders. He gained his Ph.D. degree at Yale University in 1998. He has taught at the University of Minnesota since 2000, after a period as a post-doctoral fellow in Yale Medical School’s Division of Molecular Psychiatry. Yong-Kyu Kim is Senior Scientist in the Department of Biology at Emory University, and Associate Editor of Behavior Genetics. His research includes mating behavior, speciation, sexual selection, and epigenetics using Drosophila as a model system. He received his Ph.D. degree at the City University of New York in 1994 and trained as post-doctoral fellow at SUNY under Professor Lee Ehrman. He has taught several behavior genetics courses at the University of Georgia since 1998. He edited Handbook of Behavior Genetics (2009) and is a co-author of Behavior Genetics and Evolution (3rd ed).

Bibliographic Information

  • Book Title: Animal Models of Behavior Genetics

  • Editors: Jonathan C. Gewirtz, Yong-Kyu Kim

  • Series Title: Advances in Behavior Genetics

  • DOI: https://doi.org/10.1007/978-1-4939-3777-6

  • Publisher: Springer New York, NY

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: Springer Science+Business Media New York 2016

  • Hardcover ISBN: 978-1-4939-3775-2Published: 11 August 2016

  • Softcover ISBN: 978-1-4939-8136-6Published: 21 April 2018

  • eBook ISBN: 978-1-4939-3777-6Published: 10 August 2016

  • Series ISSN: 2698-3834

  • Series E-ISSN: 2698-3842

  • Edition Number: 1

  • Number of Pages: XVI, 389

  • Number of Illustrations: 5 b/w illustrations, 22 illustrations in colour

  • Topics: Human Genetics, Psychiatry, Developmental Psychology, Neurosciences

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