Mitochondria and Cell Death

1. Front Matter

   Pages i-xiv

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2. Lethal and Nonlethal Functions of the Permeability Transition Pore

   • Eric Fontaine, Paolo Bernardi

   Pages 1-15

3. Mitochondrial Calcium and Ischemia: Reperfusion Injury in Heart

   • Liron Boyman, George S. B. Williams, W. Jonathan Lederer

   Pages 17-43

4. Mislocalization of Mitochondrial Intermembrane Space Proteins

   • Lorna Flanagan, Federico Lucantoni, J. H. M. Prehn

   Pages 45-67

5. Bcl-2 Protein Interplay on the Outer Mitochondrial Membrane

   • Frank Edlich, Jean-Claude Martinou

   Pages 69-83

6. Remodeling of Mitochondria in Apoptosis

   • Guy A. Perkins, Mark H. Ellisman

   Pages 85-110

7. Physiologic and Pathologic Functions of Mitochondrial ROS

   • Bryan G. Allen, Douglas R. Spitz

   Pages 111-130

8. Mitochondrial Mutagenesis in Cancer

   • William J. Valente, Jason H. Bielas

   Pages 131-148

9. Mitochondrial UPR in Cancer

   • Doris Germain

   Pages 149-167

10. Mitochondrial Signaling

    • Nuno Raimundo, Lorena Fernandez-Mosquera, King Faisal Yambire

    Pages 169-186

11. Mitochondria and Antiviral Immunity

    • Sunil Thomas, Michael Gale Jr.

    Pages 187-212

12. Mitochondrial Permeabilization: From Lethality to Vitality

    • Andrew Oberst, Gabriel Ichim, Stephen W. G. Tait

    Pages 213-226

13. Back Matter

    Pages 227-232

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This volume examines the role of mitochondria in different types of cell death, including apoptotic and necrotic cell deaths. Topics discussed include mitochondrial outer membrane permeabilization (MOMP) and the permeability transition pore; core processes such as calcium handling, fission and fusion, reactive oxygen species generation, and maintenance of mitochondrial DNA fidelity and protein folding homeostasis; and retrograde signaling between mitochondria and other cellular components, including the important role of mitochondria in antiviral immunity. The expertly authored chapters are drawn from multidisciplinary international perspectives, lending a nuanced and comprehensive approach to the material.
 
Mitochondria and Cell Death, part of the Cell Death in Biology and Diseases series, is invaluable reading for graduate students, researchers, and clinicians in the fields of neuroscience, oncology, gastroenterology, and hepatology,as well as those interested in the study of mitochondria and cell biology.

• Apoptosis
• intermembrane space
• interorganelle associations
• membrane permeability
• mitochondrial dynamics
• necroptosis
• sphingolipids
• Cell Cycle Analysis

• Clinical Research Divison, Fred Hutchinson Cancer Research Center, Seattle, USA

  David M. Hockenbery

David M. Hockenbery, MD is Professor, Member & Head of the Gastroenterology & Hepatology Section of the Fred Hutchinson Cancer Research Center, Seattle Cancer Care Alliance. He is also a Mentor in the Seattle Children’s/UW/Hutchinson Center Pediatric Hematology-Oncology Fellowship Program. He received his M.D. from Washington University in St. Louis, completed his Residency in Medicine at Johns Hopkins and also completed two Fellowships, in Gastroenterology and Molecular Oncology, at Washington University. Dr. Hockenbery’s current research interests include the bcl-2 oncogene and its role in apoptosis, mitochondrial biology and bioenergetic metabolism, utilizing cell culture, transgenic mouse and protein biochemistry approaches for identification of cancer-selective metabolic pathways and discovery of small molecule inhibitors targeting these pathways.

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