Overview
- Features methods for detecting and quantitating apoptosis due to toxicological stresses
- Aids researchers in distinguishing between apoptosis and other forms of programmed cell death, i.e. necrosis or autophagic cell death
- Includes tips from the experts on how to best implement the detailed methodologies
- Includes supplementary material: sn.pub/extras
Part of the book series: Methods in Pharmacology and Toxicology (MIPT)
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Table of contents (13 protocols)
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Front Matter
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Back Matter
Keywords
About this book
This detailed volume provides a single, valuable reference source for methods that definitively identify and accurately quantify apoptosis. The book begins with common methods utilized to detect and quantitate apoptosis, as well as apoptosis signaling pathways in toxicological and other related research. It continues with multi-parametric and phased apoptosis assays for detecting early and late apoptosis or distinguishing apoptosis from necrosis and autophagy. Subsequent chapters focus on recent advances in real time and high-throughput assays that detect and quantitate apoptosis and apoptosis signaling pathways. Final chapters focus on recent developments in preclinical anticancer therapeutics targeting apoptosis. Written for the Methods in Pharmacology and Toxicology series, chapters feature step-by-step descriptions of the methodologies, as well as expert tips and implementation advice.
Vital and authoritative, Apoptosis Methods in Toxicology serves novice scientists as well as experts, utilizing a range of instruments from common laboratory equipment to high-end expensive and automated machinery capable of performing real time apoptotic measurements.
Editors and Affiliations
Bibliographic Information
Book Title: Apoptosis Methods in Toxicology
Editors: Perpetua M. Muganda
Series Title: Methods in Pharmacology and Toxicology
DOI: https://doi.org/10.1007/978-1-4939-3588-8
Publisher: Humana New York, NY
eBook Packages: Springer Protocols
Copyright Information: Springer Science+Business Media New York 2016
Hardcover ISBN: 978-1-4939-3586-4Published: 14 April 2016
Softcover ISBN: 978-1-4939-8086-4Published: 19 April 2018
eBook ISBN: 978-1-4939-3588-8Published: 13 April 2016
Series ISSN: 1557-2153
Series E-ISSN: 1940-6053
Edition Number: 1
Number of Pages: X, 244
Number of Illustrations: 11 b/w illustrations, 35 illustrations in colour
Topics: Pharmacology/Toxicology, Cell Cycle Analysis, Apoptosis