Fetal Stem Cells in Regenerative Medicine

1. Front Matter

   Pages i-xix

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2. Fetal Cell Biology

   1. Front Matter

      Pages 1-1

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   2. Historical Perspectives

      • Scott M. Deeney, Timothy M. Crombleholme

      Pages 3-32

   3. Feto-Maternal Cell Trafficking and Labor

      • S. Christopher Derderian, Cerine Jeanty, Tippi C. MacKenzie

      Pages 33-45

   4. Paracrine Effects of Fetal Stem Cells

      • Mariusz Z. Ratajczak, Gabriela Schneider, Janina Ratajczak

      Pages 47-56

   5. Immunogenicity and Immunomodulation of Fetal Stem Cells

      • Stephen E. Sherman, David A. Hess

      Pages 57-79

   6. Embryonic Stem Cells and Fetal Development Models

      • Monika Nowak-Imialek, Heiner Niemann

      Pages 81-99

   7. Fetal Cell Reprogramming and Transformation

      • Jeong Mook Lim, Ji Yeon Ahn

      Pages 101-130

3. Amniotic Fluid and Membrane

   1. Front Matter

      Pages 131-131

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   2. Historical Perspectives

      • Joseph A. Brazzo III

      Pages 133-147

   3. Amniotic Membrane Stem Cell Populations

      • Rebecca Lim, Jean Tan, Ryan J. Hodges, Euan M. Wallace

      Pages 149-166

   4. Amniotic Fluid Stem Cell Populations

      • Julie Di Bernardo, Shaun M. Kunisaki

      Pages 167-179

   5. Amniotic Fluid Stem Cell Culture Methods

      • Dema Najem, Maria Ribecco-Lutkiewicz, Caroline Sodja, Felipe Mangoni Moretti, Danica Stanimirovic, Mahmud Bani-Yaghoub

      Pages 181-214

   6. MicroRNA Expression in Amniotic Fluid Cells

      • Maria Ribecco-Lutkiewicz, Dao Ly, Caroline Sodja, Julie Haukenfrers, Brandon Smith, Qing Yan Liu et al.

      Pages 215-228

4. Umbilical Cord and Placenta

   1. Front Matter

      Pages 229-229

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   2. Historical Perspectives

      • Karen K. Ballen

      Pages 231-240

   3. Umbilical Cord Blood Stem Cell Populations

      • David T. Harris

      Pages 241-255

   4. Wharton’s Jelly Stem Cells

      • Marina Bastawrous, Mibel M. Pabón, Sandra Acosta, Ike de la Peña, Diana Hernandez-Ontiveros, Meaghan Staples et al.

      Pages 257-276

   5. Placental Stem Cells and Culture Methods

      • Mofeedah Al Shammary, Felipe Mangoni Moretti

      Pages 277-292

5. Translational Developments

   1. Front Matter

      Pages 293-293

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This book explores the regenerative properties of fetal stem cells, from feto-maternal cell traffic through perinatal stem cells, with a discussion of key topics including stem cell banking, drug screening, in utero stem cell transplantation and ethical considerations. The expertly authored chapters also delve into embryonic, amniotic membrane, and umbilical cord blood stem cells; fetal development models; fetal cell reprogramming; culture methods; disease models; perinatal gene therapy, and more. These chapters are grouped into four sections, each discussing a separate prenatal stem cell population and providing fascinating historical contexts for our knowledge of these systems.

Featuring a foreword written by the renowned Dr. Joseph Vacanti of the Harvard Stem Cell Institute, Fetal Stem Cells in Regenerative Medicine: Principles and Translational Strategies is a welcome and timely contribution to the Stem Cell Biology and Regenerative Medicine series. It is essential reading for scientists and researchers, clinicians and residents, and advanced students involved in stem cells, regenerative medicine, tissue engineering, and related disciplines such as embryology.

• amniotic stem cells
• cord blood
• fetal stem cells
• progenitor cells
• stem cell banking
• wharton's jelly
• Cell culture

• Department of Surgery, Childrens Hosp Boston & Harvard Med, Boston, USA

  Dario O. Fauza

• Department of Cellular and Molecular Med, University of Ottawa, Faculty of Medicin, OTTAWA, Canada

  Mahmud Bani

Dr. Dario Fauza received his M.D. from the University of São Paulo Medical School, in São Paulo, Brazil, where he also received a PhD-equivalent degree. While at the University’s Hospital of Clinics, he completed an internship and residencies in both general and pediatric surgery. He then moved to the United States, where he completed different clinical and research fellowships, as well as postdoctoral training, at Boston Children's Hospital in Boston, Massachusetts. He has an extensive bibliography as well as a patent portfolio. His research is directed at developing original, more effective ways to repair birth defects, both pre- and post-natally. To that end, he has pioneered and explored a variety of approaches, including fetal tissue engineering.

Dr. Mahmud Bani received his Ph.D. in neurodevelopment from the Department of Anatomy and Cell Biology at the University of Western Ontario in Ontario, Canada. He completed an NSERC postdoctoral fellowship in the Neural Stem Cell Laboratory at Robarts Research Institute in Ontario, Canada. He is currently a senior research officer in the Department of Translational Biosciences at the National Research Council Canada in Ottawa, Canada, and an adjunct professor in the Department of Cellular and Molecular Medicine at the University of Ottawa in Ottawa, Canada. Dr. Bani's ongoing research is to better understand the cellular and molecular mechanisms of neurogenesis and to develop neuroprotection and neuroregeneration strategies for the injured brain.

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